Lambert-Eaton Myasthenic Syndrome
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What is Lambert-Eaton Myasthenic Syndrome?Is there any treatment?What is the prognosis?What research is being done?OrganizationsWhat is Lambert-Eaton Myasthenic Syndrome?
Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction-the site where nerve cells meet muscle
cells and help activate the muscles. It is caused by a disruption of electrical impulses between these nerve and muscle cells.
LEMS is an autoimmune condition; in such disorders the immune system, which normally protects the body from foreign organisms,
mistakenly attacks the body's own tissues. The disruption of electrical impulses is associated with antibodies produced as
a consequence of this autoimmunity. Symptoms include muscle weakness, a tingling sensation in the affected areas, fatigue,
and dry mouth. LEMS is closely associated with cancer, in particular small cell lung cancer. More than half the individuals
diagnosed with LEMS also develop small cell lung cancer. LEMS may appear up to 3 years before cancer is diagnosed.
Is there any treatment?
There is no cure for LEMS. Treatment is directed at decreasing the autoimmune response (through the use of steroids, plasmapheresis,
or high-dose intravenous immunoglobulin) or improving the transmission of the disrupted electrical impulses by giving drugs
such as di-amino pyridine or pyridostigmine bromide (Mestinon). For patients with small cell lung cancer, treatment of the
cancer is the first priority.
What is the prognosis?
The prognosis for individuals with LEMS varies. Those with LEMS not associated with malignancy have a benign overall prognosis.
Generally the presence of cancer determines the prognosis.
What research is being done?
The NINDS supports research on neuromuscular disorders such as LEMS with the ultimate goal of finding ways to treat, prevent,
and cure them.
Select this link
to view a list of studies currently seeking patients.
Organizations
Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
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on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined
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Last updated February 13, 2007
