Colpocephaly
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What is Colpocephaly?Is there any treatment?What is the prognosis?What research is being done?OrganizationsWhat is Colpocephaly?
Colpocephaly is a congenital brain abnormality in which the occipital horns - the posterior or rear portion of the lateral
ventricles (cavities) of the brain -- are larger than normal because white matter in the posterior cerebrum has failed to
develop or thicken. Colpocephaly, one of a group of structural brain disorders known as cephalic disorders, is characterized by microcephaly (an abnormally small head) and mental retardation. Other features may include movement
abnormalities, muscle spasms, and seizures. Although the cause of colpocephaly is unknown, researchers believe that the disorder
results from some kind of disturbance in the fetal environment that occurs between the second and sixth months of pregnancy.
Colpocephaly may be diagnosed late in pregnancy, although it is often misdiagnosed as hydrocephalus (excessive accumulation
of cerebrospinal fluid in the brain). It may be more accurately diagnosed after birth when signs of mental retardation, microcephaly,
and seizures are present.
Is there any treatment?
There is no definitive treatment for colpocephaly. Anticonvulsant medications are often prescribed to prevent seizures, and
doctors rely on exercise therapies and orthopedic appliances to reduce shrinkage or shortening of muscles.
What is the prognosis?
The prognosis for individuals with colpocephaly depends on the severity of the associated conditions and the degree of abnormal
brain development. Some children benefit from special education.
What research is being done?
The National Institute of Neurological Disorders and Stroke (NINDS), and other institutes of the National Institutes of Health
(NIH), conduct research related to colpocephaly and other cephalic disorders in laboratories at the NIH, and also support
additional research through grants to major medical institutions across the country. Much of this research focuses on finding ways to prevent brain abnormalities such as colpocephaly.
Select this link
to view a list of studies currently seeking patients.
Organizations
Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
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or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice
on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined
that patient or is familiar with that patient's medical history.
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Last updated February 12, 2007
