General Precautions with Refludan:

• Your doctor will monitor your treatment by using a test that measures the clotting time of your blood.
• The dosage of Refludan may be decreased if you have liver or kidney disease.

What should I tell my doctor or health care provider?

Because certain other medications can interact with Refludan, and increase the risk of bleeding, review all medications that you are taking with your health care provider, including those that you take without a prescription. Other drugs that break up or dissolve clots, such as (rt-PA) or streptokinase, or drugs that prevent clots such as Coumadin, warfarin, or aspirin, can increase your risk of bleeding.

What are some possible side effects of Refludan? (This is NOT a complete list of side effects reported with Refludan. Your health care provider can discuss with you a more complete list of side effects.)

Bleeding was the most common adverse event reported during testing of the product. Bleeding can be severe.

Other side effects occurring in at least 2% of the people studied:

• Abnormal liver function
• Allergic skin reactions

For more detailed information about Refludan, ask your health care provider.

Future Link to Refludan's Labeling

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Revised: 7/25/00