What is pegademase bovine?
Pegademase bovine is the enzyme called adenosine deaminase (ADA). Without ADA, certain
proteins accumulate that harm white blood cells. White blood cells are important for protecting the
body from infection.
Pegademase bovine is used to replenish ADA which allows an increase in white blood cells and
decreases the risk of infection in conditions such as severe combined immunodeficiency disease
(SCID).
Pegademase bovine may also be used for purposes other than those listed in this medication
guide.
What should I discuss with my healthcare provider before taking pegademase bovine?
Before using pegademase bovine, tell your doctor if you
You may not be able to use pegademase bovine or you may require a
dosage adjustment or special monitoring if you have any of the conditions listed above.
Pegademase bovine is in the FDA pregnancy category C. This means that it is not known
whether pegademase bovine will be harmful to an unborn baby. Do not use pegademase bovine without
first talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether pegademase bovine will be harmful to a nursing baby. Do not use
pegademase bovine without first talking to your doctor if you are breast-feeding a baby.
How should I take pegademase bovine?
Use pegademase bovine exactly as directed by your doctor. If you do not understand these
instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Pegademase bovine is given by intramuscular (IM) injection. Your doctor, nurse, or pharmacist
will give you specific instructions on how and where to inject the medication.
Do not administer an injection if you are unsure how to properly do so, how much to inject,
or how often to inject the medication. Call your doctor, nurse, or pharmacist to go over the instructions
with you.
Pegademase bovine is usually administered once every 7 days.
Do not inject a pegademase bovine that is discolored or that has particles in it.
Properly store and discard all syringes and needles.
Your doctor may want you to have regularly scheduled blood tests while using pegademase
bovine to monitor effectiveness and possible side effects of the medication.
Do not stop taking pegademase bovine without talking to your doctor. It may take several
weeks to 6 months to be fully effective. Stopping pegademase bovine may cause your immune system
to become less effective and serious infections may occur.
Store pegademase bovine in the refrigerator between 2 and 8 degrees Celsius (36 to 46
degrees Fahrenheit) away from light, moisture, and the reach of children. Avoid freezing the medication.
Do not use this product if there are any indications that it may have frozen.
What happens if I miss a dose of pegademase bovine?
Contact your doctor as soon as possible if you miss a dose of this medication.
Where can I get more information about pegademase bovine?
Your pharmacist has information about pegademase bovine written for health professionals that you may read.
What are the possible side effects of pegademase bovine?
If you experience any of the following serious side effects, stop using the pegademase
bovine and seek emergency medical treatment or contact your doctor immediately:
-
an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives); or
-
signs of infection such as sore throat, fever or congestion.
Other, less serious side effects may be more likely to occur. Continue to use
the pegademase bovine and talk to your doctor if you experience:
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about pegademase bovine?
Do not administer an injection if you are unsure how to properly do so, how much to inject,
or how often to inject the medication. Call your doctor, nurse, or pharmacist to go over the instructions
with you.
Contact your doctor if you develop a fever; chills; sore throat; congestion; or redness, pain,
or swelling around a wound or sore while using pegademase bovine. These may be signs of infection.
What should I avoid while taking pegademase bovine?
There are no restrictions regarding foods, beverages, or activities during treatment with
pegademase bovine unless otherwise directed by your doctor.
What other drugs will affect pegademase bovine?
Before using this medication, tell your doctor if you
You may not be able to use the pegademase bovine or you may require a
dosage adjustment or special monitoring if you are taking the medication listed above.
Drugs other than those listed here may also interact with pegademase bovine. Talk to your
doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal
products.
What happens if I have an overdose of pegademase bovine?