Laronidase is used to treat some of the symptoms of a genetic condition called Hurler
syndrome. Hurler syndrome is also called mucopolysaccharidosis
(MYOO-koe-pol-ee-SAK-a-rye-DOE-sis).
Hurler syndrome is a metabolic disorder in which the body lacks the enzyme needed to
break down certain sugars and proteins. These substances can build up in the body, causing
enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart
problems, vision or hearing loss, and changes in mental or physical abilities.
Laronidase may improve breathing and walking ability in people with this condition.
However, this medication is not a cure for Hurler syndrome.
Laronidase may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking laronidase?
You should not use this medication if you are allergic to laronidase.
Before using laronidase, tell your doctor if you are allergic to any drugs.
Your name may need to be listed on a patient registry while you are using this medication.
The purpose of this registry is to track the progression of this disorder and the effects that
laronidase has on long-term treatment of Hurler syndrome.
FDA pregnancy category B. This medication is not expected to be harmful to an
unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether laronidase passes into breast milk or if it could harm a
nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a
baby.
How should I take laronidase?
Laronidase is given as an injection through a needle placed into a vein. You will most
likely receive this injection in a clinic or hospital setting. Laronidase is usually given once per
week.
The medicine must be given slowly through an IV infusion, and can take up to 4
hours to complete.
Your doctor may also prescribe other medications to help prevent an allergic reaction to
laronidase. Take all of your medications as directed.
To be sure this medication is helping your condition and not causing harmful effects, your
doctor will need to check your progress on a regular basis. Do not miss any scheduled
appointments.
What happens if I miss a dose of laronidase?
Contact your doctor if you miss an appointment for your laronidase injection.
Where can I get more information about laronidase?
Your pharmacist has information about laronidase written for health professionals that you may read.
What are the possible side effects of laronidase?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Some people receiving a laronidase injection have had a reaction to the infusion
(when the medicine is injected into the vein). Tell your caregiver right away if you have a
headache, skin rash or itching, warmth or tingly feeling, or trouble breathing when laronidase is
injected.
Less serious side effects may include:
runny or stuffy nose, sore throat, cough;
mild skin rash;
numbness or tingling; or
pain, redness, swelling, or other irritation where the
medicine was injected.
This is not a complete list of side effects and others may occur. Tell
your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about laronidase?
Laronidase may improve breathing and walking ability in people with Hurler
syndrome. However, laronidase is not a cure for this condition.
Some people receiving a laronidase injection have had a reaction to the infusion
(when the medicine is injected into the vein). Tell your caregiver right away if you have a
headache, skin rash or itching, warmth or tingly feeling, or trouble breathing when laronidase is
injected.
Your name may need to be listed on a patient registry while you are using this medication.
The purpose of this registry is to track the progression of this disorder and the effects that
laronidase has on long-term treatment of Hurler syndrome.
What should I avoid while taking laronidase?
Follow your doctor's instructions about any restrictions on food, beverages, or activity
while you are receiving laronidase.
What other drugs will affect laronidase?
There may be other drugs that can interact with laronidase. Tell your doctor about all
your prescription and over-the-counter medications, vitamins, minerals, herbal products, and
drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
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warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does
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given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
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interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
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Content provided by Multum - Last Updated 11/10/2009