What is rosiglitazone (oral)?
Rosiglitazone is an oral diabetes medicine that helps control blood sugar levels.
Rosiglitazone is for people with type 2 (non-insulin-dependent) diabetes. Rosiglitazone is
sometimes used in combination with insulin or other medications, but it is not for treating type 1
diabetes.
Rosiglitazone is not recommended for use with insulin.
Rosiglitazone may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking rosiglitazone (oral)?
Do not use rosiglitazone if you have type 1 diabetes, or if you are in a state of diabetic
ketoacidosis (call your doctor for treatment with insulin).
If you have certain conditions, you may need a dose adjustment or special tests to safely use
this medication. Before taking rosiglitazone, tell your doctor if you have:
-
congestive heart failure or heart disease;
-
a history of heart attack or stroke;
-
liver disease; or
-
eye problems caused by diabetes.
Taking certain oral diabetes medications may increase your risk of
serious heart problems. However, not treating your diabetes can damage your heart and other organs.
Talk to your doctor about the risks and benefits of treating your diabetes with rosiglitazone.
Some women using rosiglitazone have started having menstrual periods, even after not
having a period for a long time due to a medical condition. You may be able to get pregnant if your
periods restart. Talk with your doctor about the need for birth control.
Women may also be more likely than men to have bone fractures in the upper arm, hand, or
foot while taking rosiglitazone. Talk with your doctor if you are concerned about this possibility.
Categoría C del embarazo por la FDA. No se conoce si rosiglitazone le puede hacer daño
al bebé nonato. Antes de usar esta medicina, dígale a su médico usted está embarazada o planea tener
un embarazo durante su tratamiento.
It is not known whether rosiglitazone passes into breast milk or if it could harm a nursing
baby. Do not take rosiglitazone without first talking to your doctor if you are breast-feeding a baby.
How should I take rosiglitazone (oral)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
or smaller amounts, or take it for longer than recommended by your doctor. Your doctor may
occasionally change your dose to make sure you get the best results from this medication.
Rosiglitazone is usually taken in the morning and evening. You may take the medicine with or
without food.
Rosiglitazone is only part of a complete program of treatment that also includes diet, exercise,
and weight control. Your doctor may also recommend other medicines to treat your diabetes.
It is important to use this medicine regularly to get the most benefit. Get your prescription
refilled before you run out of medicine completely.
To be sure this medication is helping your condition, your blood will need to be tested on a
regular basis. Your liver function may also need to be tested, and you may need regular eye exams. It
is important that you not miss any scheduled visits to your doctor.
Your medication needs may change if you become sick or injured, if you have a serious
infection, or if you have any type of surgery. Your doctor may want you to stop taking rosiglitazone for
a short time if any of these situations affect you.
Take care not to let your blood sugar get too low, causing hypoglycemia. You may have
hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them:
-
hunger, headache, confusion, irritability;
-
drowsiness, weakness, dizziness, tremors;
-
sweating, fast heartbeat;
-
seizure (convulsions); or
-
fainting, coma (severe hypoglycemia can be fatal).
Always keep a source of sugar available in case you have symptoms of low
blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe
hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a
prescription for a glucagon emergency injection kit and tell you how to give the injection.
Store rosiglitazone at room temperature away from moisture, heat, and light.
What happens if I miss a dose of rosiglitazone (oral)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at the next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about rosiglitazone (oral)?
Your pharmacist has information about rosiglitazone (oral) written for health professionals that you may read.
What are the possible side effects of rosiglitazone (oral)?
Get emergency medical help if you have any of these signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using rosiglitazone and call your doctor at once if you have any of these serious side
effects:
-
feeling short of breath, even with mild exertion;
-
swelling or rapid weight gain;
-
chest pain or heavy feeling, pain spreading to the arm or
shoulder, sweating, general ill feeling;
-
nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
blurred vision;
-
increased thirst or hunger, urinating more than usual; or
-
pale skin, easy bruising or bleeding, weakness.
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
What is the most important information I should know about rosiglitazone (oral)?
Do not use rosiglitazone if you have type 1 diabetes, or if you are in a state of diabetic
ketoacidosis (call your doctor for treatment with insulin).
Before taking rosiglitazone, tell your doctor if you have congestive heart failure or heart disease,
a history of heart attack or stroke, liver disease, or eye problems caused by diabetes.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including
hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast
heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a
source of sugar available in case you have symptoms of low blood sugar.
Some women using rosiglitazone have started having menstrual periods, even after not
having a period for a long time due to a medical condition. You may be able to get pregnant if your
periods restart. Talk with your doctor about the need for birth control.
Women may also be more likely than men to have bone fractures in the upper arm, hand, or
foot while taking rosiglitazone. Talk with your doctor if you are concerned about this possibility.
Taking certain oral diabetes medications may increase your risk of serious heart problems.
However, not treating your diabetes can damage your heart and other organs. Talk to your doctor
about the risks and benefits of treating your diabetes with rosiglitazone.
What should I avoid while taking rosiglitazone (oral)?
Avoid drinking alcohol while taking rosiglitazone. Alcohol lowers blood sugar and may
increase the risk of hypoglycemia while you are taking this medicine.
What other drugs will affect rosiglitazone (oral)?
You may be more likely to have hyperglycemia (high blood sugar) if you are taking rosiglitazone
with other drugs that raise blood sugar. Drugs that can raise blood sugar include:
-
isoniazid;
-
diuretics (water pills);
-
steroids (prednisone and others);
-
phenothiazines (Compazine and others);
-
thyroid medicine (Synthroid and others);
-
birth control pills and other hormones;
-
seizure medicines (Dilantin and others); and
-
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are
taking rosiglitazone with other drugs that lower blood sugar. Drugs that can lower blood sugar include:
-
nonsteroidal anti-inflammatory drugs (NSAIDs);
-
aspirin or other salicylates (including Pepto-Bismol);
-
sulfa drugs (Bactrim and others);
-
a monoamine oxidase inhibitor (MAOI);
-
beta-blockers (Tenormin and others); or
-
probenecid (Benemid).
Some medications may interact with rosiglitazone. Tell your doctor if you
are using any of the following drugs:
-
gemfibrozil (Gemcor);
-
rifampin (Rifater, Rifadin, Rimactane); or
-
a nitrate drug for chest pain or heart problems, such as
nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate
(Dilatrate-SR, Isordil, Sorbitrate), or isosorbide mononitrate (Imdur, ISMO, Monoket).
This list is not complete and there may be other drugs that can interact with
rosiglitazone. Tell your doctor about all the prescription and over-the-counter medications you use.
This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start
using a new medication without telling your doctor.
What happens if I have an overdose of rosiglitazone (oral)?
