What is morphine?
Morphine is in a group of drugs called narcotic pain relievers.
Morphine is used to treat moderate to severe pain. Short-acting morphine is taken as needed
for pain. Extended-release morphine is for use when around-the-clock pain relief is needed.
Morphine is not for treating pain just after surgery unless you were already taking morphine
before the surgery.
Morphine may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking morphine?
Do not use this medication if you have ever had an allergic reaction to a narcotic medicine
(examples include codeine, methadone, Oxycontin, Darvocet, Percocet, Vicodin, Lortab, and many
others). You should also not take morphine if you are having an asthma attack or if you have a bowel
obstruction called paralytic ileus.
Morphine may be habit-forming and
should be used only by the person it was
prescribed for
. Morphine should never be given to another person, especially someone who
has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot
get to it.
Before using morphine, tell your doctor if you are allergic to any drugs, or if you have:
-
asthma, COPD, sleep apnea, or other breathing disorders;
-
liver or kidney disease;
-
underactive thyroid;
-
curvature of the spine;
-
a history of head injury or brain tumor;
-
epilepsy or other seizure disorder;
-
low blood pressure;
-
gallbladder disease;
-
Addison's disease or other adrenal gland disorders;
-
enlarged prostate, urination problems;
-
mental illness; or
-
a history of drug or alcohol addiction.
You may not be able to take morphine unless you are already being
treated with a similar opioid pain medicine and your body is tolerant to it. Talk with your doctor if you
are not sure you are opioid-tolerant.
FDA pregnancy category C. This medication may be harmful to an unborn baby, and
could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or
plan to become pregnant during treatment.
Morphine can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more sensitive to the effects of this medicine.
How should I take morphine?
Use this medication exactly as it was prescribed for you.
Never take morphine in
larger amounts, or use it for longer than recommended by your doctor.
Follow the
directions on your prescription label. Too much morphine could be very harmful. Tell your doctor if
the medicine seems to stop working as well in relieving your pain.
Do not crush, chew, or break an
extended-release tablet
. Swallow the
pill whole. It will release medicine slowly in the body. Breaking the pill would cause too much of the
drug to be released at one time.
To make swallowing easier, you may open the
extended-release capsule
and sprinkle the medicine into a spoonful of applesauce. Swallow this mixture right away without
chewing. Do not save the mixture for later use. Discard the empty capsule.
Measure the liquid form of morphine with a special dose-measuring spoon or cup, not a regular
table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms.
Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Store this medication at room temperature, away from heat, moisture, and light.
Keep track of how many pills have been used from each new bottle of this medicine. Morphine
is a drug of abuse and you should be aware if any person in the household is using this medicine
improperly or without a prescription.
After you have stopped using this medication, flush any unused pills down the toilet. Throw
away any unused liquid morphine that is older than 90 days.
What happens if I miss a dose of morphine?
Since morphine is sometimes used as needed, you may not be on a dosing schedule. If you are
using the medication regularly, take the missed dose as soon as you remember. If it is almost time for
the next dose, skip the missed dose and wait until your next regularly scheduled dose.
Do not
use extra medicine to make up the missed dose.
Extended-release morphine is
not
for use on an as-needed basis for pain.
Where can I get more information about morphine?
Your pharmacist has information about morphine written for health professionals that you may read.
What are the possible side effects of morphine?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
-
shallow breathing, slow heartbeat;
-
seizure (convulsions);
-
cold, clammy skin;
-
confusion;
-
severe weakness or dizziness; or
-
feeling light-headed, fainting.
Less serious side effects are more likely to occur, such as:
-
constipation;
-
warmth, tingling, or redness under your skin;
-
nausea, vomiting, stomach pain, diarrhea, loss of appetite;
-
dizziness, headache, anxiety;
-
memory problems; or
-
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Tell your
doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about morphine?
You may not be able to take this medicine unless you are already being treated with a similar
opioid pain medicine and your body is tolerant to it. Talk with your doctor if you are not sure you are
opioid-tolerant.
Morphine may be habit-forming and
should be used only by the person it was
prescribed for
. Morphine should never be given to another person, especially someone who
has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot
get to it.
Do not drink alcohol while you are using morphine. Dangerous side effects or death can
occur when alcohol is combined with morphine. Check your food and medicine labels to be sure these
products do not contain alcohol.
Never take more than your prescribed dose of morphine. Tell your doctor if the medicine
seems to stop working as well in relieving your pain.
Do not stop taking morphine suddenly, or you could have unpleasant withdrawal
symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the
medication.
What should I avoid while taking morphine?
Do not drink alcohol while you are taking this medication. Dangerous side effects or death
can occur when alcohol is combined with morphine. Check your food and medicine labels to be sure
these products do not contain alcohol.
Morphine can cause side effects that may impair your thinking or reactions. Be careful if
you drive or do anything that requires you to be awake and alert.
What other drugs will affect morphine?
Avoid taking morphine if you have used an MAO inhibitor such as isocarboxazid
(Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine
(Parnate) within the past 14 days. Side effects can be more severe if you use morphine before the
MAO inhibitor has cleared from your body.
Do not take morphine with other narcotic pain medications, sedatives, tranquilizers, muscle
relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects
may result.
Before taking morphine, tell your doctor if you are using pentazocine (Talwin), nalbuphine
(Nubain), butorphanol (Stadol), or buprenorphine (Buprenex, Subutex). If you are using any of these
drugs, you may not be able to use morphine, or you may need dosage adjustments or special tests
during treatment.
This list is not complete and there may be other drugs that can interact with morphine. Tell your
doctor about all the prescription and over-the-counter medications you use. This includes vitamins,
minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication
without telling your doctor.
What happens if I have an overdose of morphine?