What is cholestyramine?
Cholestyramine helps reduce cholesterol (fatty acids) in the blood. High cholesterol is
associated with an increased risk of heart disease and atherosclerosis (clogged arteries).
Cholestyramine is used to lower high levels of cholesterol in the blood, especially
low-density lipoprotein (LDL) ("bad" cholesterol).
Cholestyramine powder is also used to treat itching caused by a blockage in the bile ducts
of the gallbladder.
Cholestyramine may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking cholestyramine?
You should not take this medication if you are allergic to cholestyramine, or if you
have a blockage in your stomach or intestines.
Before taking this medication, tell your doctor if you are allergic to any drugs, or if you
have:
-
a thyroid disorder;
-
diabetes,
-
kidney disease,
-
liver disease, or
-
chronic constipation.
If you have any of these conditions, you may need a dose adjustment
or special tests to safely take cholestyramine.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant during treatment.
Taking cholestyramine can make it harder for your body to absorb certain vitamins
your body needs while you are nursing a baby. Do not take cholestyramine without telling your
doctor if you are breast-feeding.
This medication may contain phenylalanine. Talk to your doctor before using
cholestyramine if you have phenylketonuria (PKU).
How should I take cholestyramine?
Take this medication exactly as it was prescribed for you. Do not take the medication in
larger amounts or for longer than recommended by your doctor. Follow the directions on your
prescription label.
Cholestyramine is sometimes taken up to 6 times per day. Follow your doctor's
instructions.
Take cholestyramine with meals unless your doctor tells you otherwise.
Mix the cholestyramine powder with 2 to 6 ounces of water or other non-carbonated
beverage. You may also mix the powder with a brothy soup, crushed pineapple, or applesauce.
Measure the powder using the scoop provided with your medication. Do not use any other scoop
or measuring cup to measure your cholestyramine dose.
Drink extra fluids to prevent constipation while you are taking cholestyramine.
It is important to take cholestyramine regularly to get the most benefit.
Cholestyramine is only part of a complete program of treatment that may also include
diet, exercise, and weight control. Follow your diet, medication, and exercise routines very
closely.
To be sure this medication is helping your condition, your blood may need to be tested on
a regular basis. Do not miss any scheduled appointments.
Store cholestyramine at room temperature away from moisture and heat.
What happens if I miss a dose of cholestyramine?
Take the missed dose as soon as you remember. If it is almost time for your next dose,
wait until then to take the medicine and skip the missed dose.
Do not
take extra
medicine to make up the missed dose.
Where can I get more information about cholestyramine?
Your pharmacist has information about cholestyramine written for health professionals that you may read.
What are the possible side effects of cholestyramine?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
-
blood in your urine;
-
severe stomach pain;
-
ongoing constipation;
-
feeling short of breath;
-
black, bloody, or tarry stools; or
-
easy bruising or bleeding.
Less serious side effects may include:
-
mild constipation, diarrhea;
-
stomach pain, nausea, loss of appetite, weight changes;
-
bloating or gas;
-
hiccups or a sour taste in your mouth;
-
skin rash or itching;
-
irritation of your tongue;
-
itching or irritation around your rectal area;
-
muscle or joint pain; or
-
dizziness, spinning sensation; ringing in your ears.
This is not a complete list of side effects and others may occur. Tell
your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about cholestyramine?
You should not take this medication if you are allergic to cholestyramine, or if you
have a blockage in your stomach or intestines.
Before taking cholestyramine, tell your doctor if you have a thyroid disorder, diabetes,
kidney or liver disease, or chronic constipation.
Avoid taking other medications at the same time you take cholestyramine. Wait at
least 4 to 6 hours after taking cholestyramine before you take any other medications.
What should I avoid while taking cholestyramine?
Avoid taking other medications at the same time you take cholestyramine. Wait at
least 4 to 6 hours after taking cholestyramine before you take any other medications.
What other drugs will affect cholestyramine?
Cholestyramine can make it harder for your body to absorb other medications, such as:
-
a blood thinner such as warfarin (Coumadin);
-
digoxin (digitalis, Lanoxin);
-
propranolol (Inderal);
-
a diuretic (water pill);
-
thyroid hormones such as levothyroxine (Synthroid,
Levoxyl, Levothroid);
-
birth control pills or hormone replacement;
-
seizure medicines such as phenytoin (Dilantin) and
phenobarbital (Luminal, Solfoton); or
-
an antibiotic such as amoxicillin (Amoxil, Trimox, others),
doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn,
Vectrin), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), tetracycline (Brodspec, Panmycin,
Sumycin, Tetracap).
This list is not complete and there may be other drugs that can interact
with cholestyramine. Tell your doctor about all your prescription and over-the-counter
medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not
start a new medication without telling your doctor.
What happens if I have an overdose of cholestyramine?