What is sulfamethoxazole and trimethoprim?
Sulfamethoxazole and trimethoprim are both antibiotics that treat different types of infection
caused by bacteria.
The combination of sulfamethoxazole and trimethoprim is used to treat ear infections, urinary
tract infections, bronchitis, traveler's diarrhea, and Pneumocystis carinii pneumonia.
Sulfamethoxazole and trimethoprim may also be used for other purposes not listed in this
medication guide.
What should I discuss with my healthcare provider before taking sulfamethoxazole and trimethoprim?
You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, if
you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid
deficiency.
If you have certain conditions, you may need a dose adjustment or special tests to safely use
this medication. Before using sulfamethoxazole and trimethoprim, tell your doctor if you have:
FDA pregnancy category C. It is not known whether this is harmful to
an unborn baby. Before taking sulfamethoxazole and trimethoprim, tell your doctor if you are pregnant
or plan to become pregnant during treatment.
Sulfamethoxazole and trimethoprim can pass into breast milk and may harm a nursing baby.
Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medication to a child younger than 2 months old.
Older adults may be more likely to have side effects while taking this medication.
How should I take sulfamethoxazole and trimethoprim?
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or
for longer than recommended. Follow the directions on your prescription label.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon.
If you do not have a dose-measuring device, ask your pharmacist for one.
Take this medication for the full prescribed length of time. Your symptoms may improve
before the infection is completely cleared. Sulfamethoxazole and trimethoprim will not treat a viral
infection such as the common cold or flu.
Drink plenty of fluids to prevent kidney stones while you are taking trimethoprim and
sulfamethoxazole.
Store the tablets and liquid at room temperature away from moisture, heat, and light.
What happens if I miss a dose of sulfamethoxazole and trimethoprim?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait
until then to take the medicine and skip the missed dose.
Do not
take extra medicine
to make up the missed dose.
Where can I get more information about sulfamethoxazole and trimethoprim?
Your pharmacist has information about sulfamethoxazole and trimethoprim written for health professionals that you may read.
What are the possible side effects of sulfamethoxazole and trimethoprim?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
-
fever, sore throat, and headache with a severe blistering, peeling,
and red skin rash;
-
the first sign of any skin rash, no matter how mild;
-
pale skin, easy bruising or bleeding;
-
cough, feeling short of breath;
-
diarrhea that is watery or bloody;
-
feeling restless or irritable, confusion, hallucinations,
seizure;
-
slow heart rate, weak pulse, severe tingling, numbness,
muscle pain or weakness;
-
nausea, stomach pain, loss of appetite, itching, dark urine,
clay-colored stools, jaundice (yellowing of the skin or eyes);
-
fever, chills, body aches, flu symptoms; or
-
urinating less than usual or not at all.
Less serious side effects may include:
-
painful or swollen tongue;
-
dizziness, spinning sensation;
-
ringing in your ears;
-
joint pain; or
-
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about sulfamethoxazole and trimethoprim?
You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, if
you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid
deficiency.
Before using sulfamethoxazole and trimethoprim, tell your doctor if you have kidney or liver
disease, a folic acid deficiency, asthma or severe allergies, AIDS, a glucose-6-phosphate
dehydrogenase deficiency (G6PD deficiency), or if you are malnourished.
Take this medication for the full prescribed length of time. Your symptoms may improve
before the infection is completely cleared. Sulfamethoxazole and trimethoprim will not treat a viral
infection such as the common cold or flu.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have
diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the
diarrhea unless your doctor has told you to.
Avoid exposure to sunlight, sunlamps, or tanning beds. This medication can make your skin
more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF
15 or higher) when you are outdoors.
What should I avoid while taking sulfamethoxazole and trimethoprim?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have
diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the
diarrhea unless your doctor has told you to.
Avoid exposure to sunlight, sunlamps, or tanning beds. This medication can make your skin
more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF
15 or higher) when you are outdoors.
What other drugs will affect sulfamethoxazole and trimethoprim?
Tell your doctor about all other medications you use, especially:
-
seizure medication such as phenytoin (Dilantin);
-
a diuretic (water pill);
-
a blood thinner such as warfarin (Coumadin);
-
methotrexate (Trexall, Rheumatrex); or
-
an ACE inhibitor such as benazepril (Lotensin), captopril
(Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril
(Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).
This list is not complete and there may be other drugs that can interact with
sulfamethoxazole and trimethoprim. Tell your doctor about all your prescription and over-the-counter
medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a
new medication without telling your doctor.
What happens if I have an overdose of sulfamethoxazole and trimethoprim?