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If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up unless your doctor instructs you to do so. Call your doctor if you miss 2 or more doses in a row. Ask your doctor ahead of time what to do about a missed dose and follow your doctor's specific directions.

Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor. Dosage is based on your medical condition, thyroid levels and response to therapy. Take this medication 4 hours before or after taking any products containing aluminum or iron, such as antacids, sucralfate, and vitamins/minerals. Take liothyronine 4 hours before or after taking cholestyramine or colestipol. These products react with liothyronine, preventing its full absorption. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not stop taking this medication without talking with your doctor. Thyroid replacement therapy is usually taken for life. Symptoms of low thyroid levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heart rate, and sensitivity to cold. These symptoms should lessen as your body adjusts to the medication. It may take several days before you see an improvement in your condition. Inform your doctor if your condition does not improve or if it worsens after 2 to 3 days of treatment.

See also How to Use section. Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain antidepressants (e.g., TCAs such as amitriptyline, imipramine, nortriptyline), estrogen (e.g., hormone replacement therapy, birth control pill/patch/ring), drugs for diabetes (e.g., glipizide, glyburide, insulin, metformin, rosiglitazone), digoxin, ketamine, intravenous blood pressure drugs (e.g., epinephrine, norepinephrine), "blood thinners" (e.g., warfarin). Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients such as decongestants that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Do not share this medication with others. Laboratory and/or medical tests (e.g., thyroid function tests) should be performed regularly to monitor your progress or check for side effects. Some drugs (e.g., androgens, corticosteroids, estrogens, estrogen-containing birth control pills, iodine-containing products, salicylates) can interfere with thyroid function tests, possibly causing false test results. Consult your laboratory personnel or doctor for more details.

If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: fever, fast/irregular heartbeat, chest pain, confusion.

Before taking liothyronine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased adrenal gland function, kidney disease (e.g., nephrosis), low pituitary hormone (e.g., hypopituitarism), low testosterone (e.g., hypogonadism), overactive thyroid (hyperthyroidism). Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e.g., angina, high blood pressure, heart failure, irregular heartbeat, heart attack), sugar diabetes (diabetes mellitus), water diabetes (diabetes insipidus), long-term severe underactive thyroid (e.g., myxedema). Before having surgery, tell your doctor or dentist that you are using this medication. If you have diabetes, this drug may make it harder to control your blood sugar levels. Check your blood sugar regularly as directed by your doctor. Tell your doctor immediately if you have symptoms such as increased thirst/urination, shakiness, unusual sweating, or hunger. Your anti-diabetic medication or diet may need to be adjusted. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at a greater risk for heart problems while using this drug. Children may be more sensitive to the effects of thyroid hormones. Current information shows that this drug may be used during pregnancy. Consult your doctor before becoming pregnant. Liothyronine passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Nausea may occur. In rare instances, some temporary hair loss may occur during the first few months of starting this drug (especially in children). If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Though unlikely, it is possible to have too much thyroid hormone. Tell your doctor immediately if any of these unlikely but serious signs of too much thyroid hormone occur: headache, irritability, trouble sleeping, nervousness, increased sweating, heat intolerance, diarrhea, menstrual changes. Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, trouble breathing with exercise, fast/irregular/pounding heartbeat, swelling of the arms/legs, extreme weakness. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to treat thyroid cancer. Liothyronine should not be used for treating infertility in patients with normal thyroid levels. The risks of use are high, and liothyronine provides no benefit.

This medication should not be used either alone or in combination with diet pills to treat obesity/cause weight loss in patients with normal thyroid production. If used in combination with diet pills (appetite suppressant drugs), serious, even life-threatening effects could occur.