What is esterified estrogens and methyltestosterone?
Esterified estrogens are female sex hormones necessary for many processes in the body.
Methyltestosterone is a man-made form of testosterone, a naturally occurring sex hormone that
is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's
ovaries and adrenal system.
The combination of esterified estrogens and methyltestosterone is used to treat symptoms of
menopause such as hot flashes, and vaginal dryness, burning, and irritation.
This medication may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking esterified estrogens and methyltestosterone?
Esterified estrogens and methyltestosterone should not be used to prevent heart disease or
stroke.
Do not use esterified estrogens and methyltestosterone if you have:
-
liver disease;
-
a recent history of heart attack, stroke or circulation
problems;
-
abnormal vaginal bleeding that a doctor has not checked;
-
any type of breast, uterine, or hormone-dependent cancer;
or
-
if you are pregnant or breast-feeding.
Before taking this medication, tell your doctor if you have:
-
high blood pressure, heart disease, or coronary artery disease;
-
high cholesterol or triglycerides;
-
kidney disease;
-
asthma;
-
epilepsy or other seizure disorder;
-
migraines;
-
endometriosis;
-
diabetes;
-
lupus;
-
depression;
-
gallbladder disease;
-
if you smoke; or
-
if you have had your uterus removed (hysterectomy).
If you have any of these conditions, you may need a dose adjustment or
special tests to safely take this medication.
Esterified estrogens and methyltestosterone increases your risk of developing endometrial
hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using esterified
estrogens and methyltestosterone may lower this risk. If your uterus has not been removed, your
doctor may prescribe a progestin for you to take while you are using esterified estrogens and
methyltestosterone.
Long-term esterified estrogens and methyltestosterone treatment may increase your risk of
stroke. Talk with your doctor about your individual risks before using esterified estrogens and
methyltestosterone long-term. Your doctor should check your progress on a regular basis (every 3 to 6
months) to determine whether you should continue this treatment.
FDA pregnancy category X. This medication can cause birth defects.
Do not use
esterified estrogens and methyltestosterone if you are pregnant.
Tell your doctor right
away if you become pregnant during treatment.
Esterified estrogens and methyltestosterone can pass into breast milk and may harm a
nursing baby. This medication may also slow breast milk production. Do not use if you are
breast-feeding a baby.
How should I take esterified estrogens and methyltestosterone?
Use this medication exactly as it was prescribed for you. Do not use the medication in larger
amounts, or use it for longer than recommended by your doctor. Follow the directions on your
prescription label.
This medication is usually taken in a cycle of 3 weeks on and 1 week off. Follow your doctor's
instructions.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while
using esterified estrogens and methyltestosterone.
If you need to have any type of medical tests or surgery, or if you will be on bed rest, you may
need to stop using this medication for a short time. Esterified estrogens and methyltestosterone may
also cause unusual results with certain medical tests. Tell any doctor who treats you that you are taking
this medication.
Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose of esterified estrogens and methyltestosterone?
Take the medication as soon as you remember. If it is almost time for the next dose, skip the
missed dose and take your medicine at the next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about esterified estrogens and methyltestosterone?
Your pharmacist has information about esterified estrogens and methyltestosterone written for health professionals that you may read.
What are the possible side effects of esterified estrogens and methyltestosterone?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
-
chest pain or heavy feeling, pain spreading to the arm or shoulder,
nausea, sweating, general ill feeling;
-
sudden numbness or weakness, especially on one side of the
body;
-
sudden headache, confusion, problems with vision, speech,
or balance;
-
swelling, rapid weight gain;
-
confusion, unusual thoughts or behavior;
-
pain, swelling, or tenderness in your stomach;
-
nausea, stomach pain, loss of appetite jaundice (yellowing
of the skin or eyes);
-
breast lump, nipple discharge;
-
acne, skin color changes, increased facial hair, male
pattern baldness, voice changes; or
-
changes in your menstrual periods, break-through bleeding.
Less serious side effects may include:
-
mild nausea, stomach upset;
-
swollen or painful breasts;
-
headache;
-
hair loss;
-
depression, anxiety; or
-
decreased sex drive, impotence, or difficulty having an
orgasm.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
What is the most important information I should know about esterified estrogens and methyltestosterone?
Do not use this medication if you have any of the following conditions: liver disease, a recent
history of heart attack, stroke or circulation problems, a hormone-related cancer such as breast or
uterine cancer, abnormal vaginal bleeding, or if you are pregnant or breast-feeding. This medication
should not be used to prevent heart disease or stroke.
This medication can cause birth defects in an unborn baby. Do not use if
you are pregnant.
Tell your doctor if you become pregnant during treatment.
Esterified estrogens and methyltestosterone increases your risk of developing endometrial
hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using esterified
estrogens and methyltestosterone may lower this risk. If your uterus has not been removed, your
doctor may prescribe a progestin for you to take while you are taking esterified estrogens and
methyltestosterone.
Long-term esterified estrogens and methyltestosterone treatment may increase your risk of
breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using
esterified estrogens and methyltestosterone long-term. Your doctor should check your progress on a
regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while
using esterified estrogens and methyltestosterone.
What should I avoid while taking esterified estrogens and methyltestosterone?
Follow your doctor's instructions about any restrictions on food, beverages, or activity while
you are taking this medication.
What other drugs will affect esterified estrogens and methyltestosterone?
Many drugs can interact with esterified estrogens and methyltestosterone. Below is just a
partial list. Tell your doctor if you are using:
-
a blood thinner such as warfarin (Coumadin);
-
insulin;
-
ketoconazole (Nizoral);
-
St. John's wort;
-
rifampin (Rifadin, Rifater, Rifamate, Rimactane);
-
an antidepressant;
-
seizure medicines such as phenytoin (Dilantin),
carbamazepine (Tegretol), topiramate (Topamax), and others;
-
an antibiotic such as clarithromycin (Biaxin), erythromycin
(E-Mycin, Ery-Tab, Erythrocin), telithromycin (Ketek), and others; or
-
HIV/AIDS medicine such as atazanavir (Reyataz), indinavir
(Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).
This list is not complete and there may be other drugs that can interact with
esterified estrogens and methyltestosterone. Tell your doctor about all the prescription and
over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs
prescribed by other doctors. Do not start using a new medication without telling your doctor.
What happens if I have an overdose of esterified estrogens and methyltestosterone?
