This medication is a female hormone (estrogen). It is usually used in women who no longer produce the amount of estrogen they produced before menopause. This medication is absorbed through the skin, enters your bloodstream, and helps your body reach normal estrogen levels. It is a very effective treatment for reducing a common menopause symptom (intense feelings of warmth and sweating known as hot flashes). If you need treatment for vaginal menopause symptoms only (e.g., vaginal dryness), your doctor should consider products applied directly inside the vagina before medications that are taken by mouth, absorbed through the skin, or injected.
Dizziness, lightheadedness, headache, upset stomach, bloating, nausea, weight changes, increased/decreased interest in sex, breast tenderness, or skin redness/irritation at the application site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., severe depression, memory loss), breast lumps, swelling hands/feet, unusual vaginal bleeding (e.g., spotting, sudden bleeding, prolonged/returning bleeding), unusual vaginal discharge/itching/odor, yellowing eyes/skin, stomach/abdominal/pelvic pain, persistent nausea/vomiting, dark urine, worsening of seizures, signs of worsening diabetes control (e.g., increased thirst and urination). This medication may infrequently cause serious problems such as heart attacks, stroke, and blood clots. Seek immediate medical attention if you experience any of the following: chest/jaw/left arm pain, sudden severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (e.g., double vision, loss of vision), pain/redness/swelling of legs, trouble breathing, coughing up blood, sudden dizziness/fainting. A serious allergic reaction to this drug is rare. However, seek immediate medical attention you have any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.