What is indomethacin?
Indomethacin is in a group of drugs called nonsteroidal anti-inflammatory drugs
(NSAIDs). Indomethacin works by reducing hormones that cause inflammation and pain in the
body.
Indomethacin is used to treat pain or inflammation caused by many conditions such as
arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis.
Indomethacin may also be used for other purposes not listed in this medication guide.
What does indomethacin look like?
Indomethacin 50 mg-MYL
Indomethacin 50 mg-ESI
Indomethacin 25 mg-MYL
Indomethacin 25 mg-TEV
Indomethacin 50 mg-TEV
Indomethacin 75 mg SR-EON
Indomethacin 50 mg-IVA
What should I discuss with my healthcare provider before taking indomethacin?
Taking an NSAID can increase your risk of life-threatening heart or circulation problems,
including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not
use this medicine just before or after having heart bypass surgery (also called coronary artery
bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines,
including bleeding or perforation (forming of a hole). These conditions can be fatal and
gastrointestinal effects can occur without warning at any time while you are taking an NSAID.
Older adults may have an even greater risk of these serious gastrointestinal side effects.
Do not use this medication if you are allergic to indomethacin, or if you have a
history of allergic reaction to aspirin or other NSAIDs.
Before taking indomethacin tell your doctor if you are allergic to any drugs, or if you
have:
-
a history of heart attack, stroke, or blood clot;
-
heart disease, congestive heart failure, high blood
pressure;
-
a history of stomach ulcers or bleeding;
-
liver or kidney disease,
-
a seizure disorder such as epilepsy;
-
asthma;
-
polyps in your nose;
-
a bleeding or blood clotting disorder; or
-
if you smoke.
If you have any of these conditions, you may need a dose adjustment
or special tests to safely take indomethacin.
FDA pregnancy category C. This medication may be harmful to an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Taking indomethacin during the last 3 months of pregnancy may harm the unborn baby.
Do not take indomethacin during pregnancy unless your doctor has told you to.
Indomethacin passes into breast milk and may affect a nursing baby. Do not take
indomethacin without first talking to your doctor if you are breast-feeding a baby.
Do not give this medicine to a child younger than 14 years old without the advice of a
doctor.
How should I take indomethacin?
Take this medication exactly as it was prescribed for you. Do not take the medication in
larger amounts, or take it for longer than recommended by your doctor. Follow the directions on
your prescription label.
Take indomethacin with food or milk to lessen stomach upset.
Do not crush, chew, break, or open an extended-release capsule. Swallow the pill
whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill
would cause too much of the drug to be released at one time.
Shake the oral suspension (liquid) well just before you measure a dose. To be sure
you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not
with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for
one.
If you take indomethacin for a long period of time, your doctor may want to check you on
a regular basis to make sure this medication is not causing harmful effects. Do not miss any
scheduled visits to your doctor.
This medication can cause you to have unusual results with certain medical tests. Tell any
doctor who treats you that you are using indomethacin.
Store indomethacin at room temperature away from moisture and heat. Do not allow
the liquid medicine to freeze.
What happens if I miss a dose of indomethacin?
If you are taking indomethacin on a regular schedule, take the missed dose as soon as you
remember. However, if it is almost time for the next dose, skip the missed dose and take only the
next regularly scheduled dose.
Do not
take a double dose.
If you are taking indomethacin as needed, take the missed dose if it is needed, then wait
the recommended or prescribed amount of time before taking another dose.
Where can I get more information about indomethacin?
Your pharmacist has information about indomethacin written for health professionals that you may read.
What are the possible side effects of indomethacin?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking indomethacin and seek medical attention or call your doctor at once if
you have any of these serious side effects:
-
chest pain, weakness, shortness of breath, slurred speech, problems
with vision or balance;
-
black, bloody, or tarry stools;
-
coughing up blood or vomit that looks like coffee grounds;
-
swelling or rapid weight gain;
-
urinating less than usual or not at all;
-
nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
fever, sore throat, and headache with a severe blistering,
peeling, and red skin rash; or
-
bruising, severe tingling, numbness, pain, muscle weakness.
Less serious side effects may include:
-
upset stomach, mild heartburn, diarrhea, constipation;
-
bloating, gas;
-
dizziness, nervousness, headache;
-
skin rash, itching;
-
blurred vision; or
-
ringing in your ears.
This is not a complete list of side effects and others may occur. Tell
your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about indomethacin?
This medicine can increase your risk of life-threatening heart or circulation problems,
including heart attack or stroke. This risk will increase the longer you use indomethacin. Do not
use this medicine just before or after having heart bypass surgery (also called coronary artery
bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems,
such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or
balance.
This medicine can also increase your risk of serious effects on the stomach or intestines,
including bleeding or perforation (forming of a hole). These conditions can be fatal and
gastrointestinal effects can occur without warning at any time while you are taking indomethacin.
Older adults may have an even greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines.
This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee
grounds.
Do not drink alcohol while taking indomethacin. Alcohol can increase the risk of
stomach bleeding caused by indomethacin.
Do not use any other over-the-counter cold, allergy, or pain medication without first
asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or
other medicines similar to indomethacin (such as ibuprofen, ketoprofen, or naproxen). If you
take certain products together you may accidentally take too much of this type of medication.
Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen,
ketoprofen, or naproxen.
What should I avoid while taking indomethacin?
Do not drink alcohol while taking indomethacin. Alcohol can increase the risk of
stomach bleeding caused by indomethacin.
Do not use any other over-the-counter cold, allergy, or pain medication without first
asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or
other medicines similar to indomethacin (such as ibuprofen, ketoprofen, or naproxen). If you
take certain products together you may accidentally take too much of this type of medication.
Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen,
ketoprofen, or naproxen.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds).
Indomethacin can make your skin more sensitive to sunlight and sunburn may result. Use a
sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
What other drugs will affect indomethacin?
Tell your doctor if you are taking an antidepressant such as citalopram (Celexa),
duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax),
fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking
any of these drugs with indomethacin may cause you to bruise or bleed easily.
Before taking indomethacin, tell your doctor if you are taking any of the following drugs:
-
a blood thinner such as warfarin (Coumadin);
-
cyclosporine (Gengraf, Neoral, Sandimmune);
-
digoxin (digitalis, Lanoxin);
-
diuretics (water pills) such as furosemide (Lasix);
-
lithium (Eskalith, Lithobid);
-
methotrexate (Rheumatrex, Trexall);
-
probenecid (Benemid);
-
steroids (prednisone and others);
-
aspirin or other NSAIDs (non-steroidal anti-inflammatory
drugs) such as diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen
(Ansaid), ibuprofen (Advil, Motrin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid
(Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam
(Feldene), and others; or
-
a beta-blocker such as atenolol (Tenormin), bisoprolol
(Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard),
propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others.
This list is not complete and there may be other drugs that can interact
with indomethacin. Tell your doctor about all the prescription and over-the-counter medications
you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start using a new medication without telling your doctor.
What happens if I have an overdose of indomethacin?
