What is lansoprazole and naproxen?
Naproxen is in a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs). It
works by reducing substances in the body that cause inflammation, pain, and fever.
Lansoprazole is in a group of drugs called proton pump inhibitors. It decreases the amount of
acid produced in the stomach.
The combination of lansoprazole and naproxen is used to treat symptoms of osteoarthritis,
rheumatoid arthritis, and ankylosing spondylitis. The lansoprazole in this medication helps reduce the
risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.
Lansoprazole and naproxen may also be used for purposes other than those listed in this
medication guide.
What should I discuss with my healthcare provider before taking lansoprazole and naproxen?
Do not use this medication if you are allergic to lansoprazole (Prevacid) or naproxen
(Aleve, Anaprox, Naprosyn, and others), or if you have ever had a severe allergic reaction to aspirin or
other NSAIDs.
Taking an NSAID can increase your risk of life-threatening heart or circulation problems,
including heart attack or stroke. This risk will increase the longer you use the NSAID. Do not use this
medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or
CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines, including
bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects
can occur without warning at any time while you are taking an NSAID. Older adults may have an even
greater risk of these serious gastrointestinal side effects.
If you have certain conditions, you may need a dose adjustment or special tests to safely take
this lansoprazole and naproxen. Before using this medication, tell your doctor if you have:
-
liver or kidney disease;
-
heart disease, high blood pressure, or a history of stroke,
heart attack, or congestive heart failure;
-
a bleeding or blood clotting disorder, such as hemophilia;
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a history of stomach ulcers or bleeding; or
-
asthma, or a history of allergic reaction to aspirin,
especially aspirin triad syndrome.
FDA pregnancy category C. It is not known whether this medication is
harmful to an unborn baby. Before you take lansoprazole and naproxen, tell your doctor if you are
pregnant or plan to become pregnant during treatment.
Naproxen can pass into breast milk and may harm a nursing baby. It is not known whether
lansoprazole passes into breast milk or if it could harm a nursing baby. Do not use this medication
without telling your doctor if you are breast-feeding a baby.
How should I take lansoprazole and naproxen?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
amounts, or take it for longer than recommended by your doctor. Follow the directions on your
prescription label.
Each package of this medication contains pills for 7 days of treatment (one lansoprazole capsule
and two naproxen tablets per day). Follow your doctor's instructions about when to take each pill.
In most cases, you will take one lansoprazole (Prevacid) capsule and one naproxen (Naprosyn)
tablet each morning before eating. The second naproxen tablet is then taken 12 hours later, without
lansoprazole.
Take this medication with a full glass of water.
Do not crush, chew, break, or open the lansoprazole capsule. Swallow the pill whole. It is
specially made to release medicine slowly in the body. Breaking or opening the pill would cause too
much of the drug to be released at one time.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a
regular basis. Your kidney or liver function may also need to be tested. You may also need eye exams
if you have any changes in your vision. Do not miss any scheduled visits to your doctor.
This medication can cause you to have unusual results with certain medical tests. Tell any
doctor who treats you that you are using naproxen.
Store this medicine at room temperature away from moisture, heat, and light.
What happens if I miss a dose of lansoprazole and naproxen?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at your next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about lansoprazole and naproxen?
Your pharmacist has information about lansoprazole and naproxen written for health professionals that you may read.
What are the possible side effects of lansoprazole and naproxen?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side
effects:
-
chest pain or heavy feeling, pain spreading to the arm or shoulder,
nausea, sweating, general ill feeling;
-
sudden numbness or weakness, especially on one side of the
body;
-
sudden headache, confusion, problems with vision, speech,
or balance;
-
swelling, rapid weight gain, feeling short of breath, even
with mild exertion;
-
black, bloody, or tarry stools, coughing up blood or vomit
that looks like coffee grounds;
-
nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
-
fever, sore throat, and headache with a severe blistering,
peeling, and red skin rash; or
-
pale skin, easy bruising, weakness.
Less serious side effects may include:
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mild stomach pain, constipation, nausea, heartburn;
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headache, dizziness or drowsiness;
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sweating, mild skin rash or itching; or
-
ringing in your ears.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about lansoprazole and naproxen?
The naproxen in this medicine can increase your risk of life-threatening heart or circulation
problems, including heart attack or stroke. This risk will increase the longer you use naproxen. Do not
use this medicine just before or after having heart bypass surgery (also called coronary artery bypass
graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such
as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
Naproxen can also increase your risk of serious effects on the stomach or intestines, including
bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects
can occur without warning at any time while you are taking naproxen. Older adults may have an even
greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines.
This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee
grounds.
Do not use any other over-the-counter pain or arthritis medication without first asking your
doctor or pharmacist. Naproxen is contained in many medicines available over the counter. Read the
label of any other medicine you are using to see if it contains naproxen.
What should I avoid while taking lansoprazole and naproxen?
Avoid taking sucralfate (Carafate) or antacids that contain magnesium or aluminum (such as
Maalox, Mylanta, or Rolaids) at the same time you take lansoprazole and naproxen. These other
medications can make it harder for your body to absorb lansoprazole and naproxen.
Do not use any other over-the-counter pain or arthritis medication without first asking your
doctor or pharmacist. Naproxen is contained in many medicines available over the counter. If you
take certain products together you may accidentally take too much naproxen. Read the label of any
other medicine you are using to see if it contains naproxen.
If you drink more than three alcoholic beverages per day, do not take this medication
without your doctor's advice. Alcohol and naproxen together may increase the risk of bleeding in the
stomach.
Avoid exposure to sunlight, sunlamps, or tanning beds. Naproxen can make your skin more
sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or
higher) when you are outdoors.
What other drugs will affect lansoprazole and naproxen?
Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine
(Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox),
paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with
naproxen may increase your risk of stomach bleeding.
Before taking this medication, tell your doctor if you are using any of the following drugs:
-
atazanavir (Reyataz);
-
a blood thinner such as warfarin (Coumadin);
-
cholestyramine (Prevalite, Questran);
-
clopidogrel (Plavix);
-
diabetes medications you take by mouth;
-
digoxin (digitalis, Lanoxin);
-
an iron supplement;
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lithium (Eskalith, Lithobid, others);
-
methotrexate (Rheumatrex, Trexall);
-
phenytoin (Dilantin);
-
probenecid (Benemid);
-
theophylline (Elixophyllin, Theo-24, Uniphyl);
-
steroids (prednisone and others);
-
a diuretic (water pill) such as furosemide (Lasix);
-
an antibiotic such as ampicillin (Principen) or ketoconazole
(Nizoral);
-
aspirin or other NSAIDs such as ibuprofen (Motrin, Advil),
naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin (Indocin), ketoprofen (Orudis),
and others;
-
an ACE inhibitor such as benazepril (Lotensin), captopril
(Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril
(Accupril), and others; or
-
a beta-blocker such as atenolol (Tenormin), carvedilol
(Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard),
propranolol (Inderal, InnoPran), sotalol (Betapace), and others.
This list is not complete and there may be other drugs that can interact with
lansoprazole and naproxen. Tell your doctor about all the prescription and over-the-counter
medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start using a new medication without telling your doctor.
What happens if I have an overdose of lansoprazole and naproxen?
