What is prochlorperazine (oral)?
Prochlorperazine is an anti-psychotic medication in a group of drugs called phenothiazines
(FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.
Prochlorperazine is used to treat psychotic disorders such as schizophrenia. It is also used to
treat anxiety, and to control severe nausea and vomiting.
Prochlorperazine may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking prochlorperazine (oral)?
Prochlorperazine is not for use in psychotic conditions related to dementia.
Prochlorperazine may cause heart failure, sudden death, or pneumonia in older adults with
dementia-related conditions.
Do not use prochlorperazine if you have brain damage, bone marrow depression, or are
also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to
prochlorperazine or other phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil),
perphenazine (Trilafon), promethazine (Adgan, Pentazine, Phenergan), thioridazine (Mellaril), or
trifluoperazine (Stelazine).
If you have certain conditions, you may need a dose adjustment or special tests to safely use
this medication. Before you take prochlorperazine, tell your doctor if you have:
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glaucoma;
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heart disease or high blood pressure;
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liver or kidney disease;
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severe asthma, emphysema, or other breathing problem;
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a history of seizures;
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adrenal gland tumor (pheochromocytoma);
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Parkinson's disease;
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an enlarged prostate or urination problems;
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an infectious disease such as chickenpox, measles, stomach
flu, or an infection of the central nervous system;
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past or present breast cancer;
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low levels of calcium in your blood (hypocalcemia); or
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if you have ever had a serious side effect while using
prochlorperazine or another phenothiazine.
Tell your doctor if you will be exposed to extreme heat or cold, or to
insecticide poisons while you are taking prochlorperazine.
It is not known whether prochlorperazine will harm an unborn baby. Prochlorperazine may
cause side effects in a newborn if the mother takes the medication during pregnancy. Do not take this
medication without first talking to your doctor if you are pregnant. Tell your doctor if you become
pregnant while taking prochlorperazine.
Prochlorperazine can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more likely to have side effects from this medication.
Prochlorperazine is not for use in children younger than 2 years old or weighing less than 20
pounds. Talk with your doctor before giving this medication to a child who has been ill with a fever or
flu symptoms.
How should I take prochlorperazine (oral)?
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or
for longer than recommended. Follow the directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results from this medication.
This medication can cause you to have unusual results with certain medical tests. Tell any
doctor who treats you that you are using prochlorperazine.
If you need to have an x-ray or CT scan of your spinal column using a dye that is injected into a
vein, you may need to temporarily stop taking prochlorperazine. Be sure the doctor knows ahead of
time that you are using this medication.
Do not stop using prochlorperazine suddenly after long-term use, or you could have
unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky. Talk to your
doctor about how to avoid withdrawal symptoms when you stop using prochlorperazine.
Store prochlorperazine at room temperature away from moisture, heat, and light.
What happens if I miss a dose of prochlorperazine (oral)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait
until then to take the medicine and skip the missed dose.
Do not
take extra medicine
to make up the missed dose.
Where can I get more information about prochlorperazine (oral)?
Your pharmacist has information about prochlorperazine (oral) written for health professionals that you may read.
What are the possible side effects of prochlorperazine (oral)?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using prochlorperazine and call your doctor at once if you have a serious side effect
such as:
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twitching or uncontrollable movements of your eyes, lips, tongue,
face, arms, or legs;
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tremor (uncontrolled shaking), drooling, trouble
swallowing, problems with balance or walking;
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feeling restless, jittery, or agitated;
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high fever, stiff muscles, confusion, sweating, fast or
uneven heartbeats, rapid breathing;
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feeling like you might pass out;
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seizure (black-out or convulsions);
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decreased night vision, tunnel vision, watery eyes, increased
sensitivity to light;
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nausea and stomach pain, skin rash, and jaundice
(yellowing of the skin or eyes);
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pale skin, easy bruising or bleeding, fever, sore throat, flu
symptoms;
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urinating less than usual or not at all;
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joint pain or swelling with fever, swollen glands, muscle
aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
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slow heart rate, weak pulse, fainting, slow breathing
(breathing may stop).
Less serious side effects may include:
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dizziness, drowsiness, anxiety;
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sleep problems (insomnia), strange dreams;
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dry mouth, stuffy nose;
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blurred vision;
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constipation;
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breast swelling or discharge;
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a missed menstrual period;
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weight gain, swelling in your hands or feet;
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impotence, trouble having an orgasm;
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mild itching or skin rash; or
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headache.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about prochlorperazine (oral)?
Stop using this medication and call your doctor at once if you have twitching or
uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of
dangerous side effects.
Prochlorperazine is not for use in psychotic conditions related to dementia.
Prochlorperazine may cause heart failure, sudden death, or pneumonia in older adults with
dementia-related conditions.
Do not use prochlorperazine if you have brain damage, bone marrow depression, or are
also using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to
prochlorperazine or other phenothiazines.
Before you take prochlorperazine, tell your doctor if you have glaucoma, heart disease or high
blood pressure, liver or kidney disease, severe asthma or breathing problems, a history of seizures,
adrenal gland tumor, Parkinson's disease, enlarged prostate or urination problems, an infectious disease
(such as chickenpox, measles, flu, or central nervous system infection), past or present breast cancer,
low levels of calcium in your blood, or if you have ever had a serious side effect while using
prochlorperazine or similar medicines.
Before taking prochlorperazine,
tell your doctor about all other medications you
use.
What should I avoid while taking prochlorperazine (oral)?
Prochlorperazine can cause side effects that may impair your thinking or reactions. Be
careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast
from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a
fall.
Avoid drinking alcohol. It can increase some of the side effects of prochlorperazine.
Avoid exposure to sunlight or tanning beds. Prochlorperazine can make your skin more
sensitive to sunlight, and a sunburn may result. Wear sunscreen (SPF 15 or higher) and protective
clothing if you must be outdoors.
What other drugs will affect prochlorperazine (oral)?
Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers,
and medicine for seizures, depression or anxiety can interact with prochlorperazine and cause medical
problems or increase side effects. Tell your doctor if you regularly use any of these medicines, or any
other anti-psychotic medications.
Also tell your doctor if you are taking any of the following medicines:
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atropine (Atreza, Sal-Tropine);
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lithium (Eskalith, Lithobid);
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a diuretic (water pill);
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an antibiotic;
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birth control pills or hormone replacement estrogens;
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blood pressure medication;
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a blood thinner such as warfarin (Coumadin);
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certain asthma medications or bronchodilators;
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drugs to treat a prostate disorder, such as alfuzosin
(Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax);
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incontinence medications;
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insulin or diabetes medications you take by mouth;
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medication for nausea, vomiting, or motion sickness;
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medications to treat or prevent malaria;
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medications used for general anesthesia;
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medicines used to prevent organ transplant rejection;
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numbing medicine such as lidocaine or Novocain;
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a stimulant or ADHD medication;
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ulcer or irritable bowel medications; or
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medicines to treat Parkinson's disease, restless leg
syndrome, or pituitary gland tumor (prolactinoma).
This list is not complete and there are many other medicines
that can interact with prochlorperazine.
Tell your doctor about all your prescription and
over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the
medicines you use and show this list to any doctor or other healthcare provider who treats you.
What happens if I have an overdose of prochlorperazine (oral)?
