What should I avoid while taking cisapride (oral)?
Do not take cisapride with any of the following drugs: antibiotics such as clarithromycin
(Biaxin), erythromycin (Ery-Tab, E.E.S., E-Mycin, others), troleandomycin (TAO), and sparfloxacin
(Zagam); antidepressants such as amitriptyline (Elavil), maprotiline (Ludiomil), and nefazodone
(Serzone); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and
ketoconazole (Nizoral); phenothiazines such as prochlorperazine (Compazine, others) and
promethazine (Phenergan, others); antihistamines such as astemizole (Hismanal); blood pressure
medications such as bepridil (Vascor); heart medications such as procainamide (Procan SR, Procanbid,
Pronestyl) and quinidine (Quinidex, Quinaglute); and HIV medications such as indinavir (Crixivan) and
ritonavir (Norvir). Taken with any of these drugs, cisapride may cause irregular heartbeats that could
lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart
problems. Talk to your doctor or pharmacist before taking any other medications.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking
cisapride.
Use other medications cautiously during treatment with cisapride to avoid harming yourself
or others. Excessive drowsiness may result if benzodiazepines such as alprazolam (Xanax), diazepam
(Valium), chlordiazepoxide (Librium), temazepam (Restoril) are taken during cisapride therapy.
Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products
may increase amount of cisapride available in your body, which could lead to dangerous side effects.
What other drugs will affect cisapride (oral)?
Do not take cisapride with any of the following drugs: antibiotics such as clarithromycin
(Biaxin), erythromycin (Ery-Tab, E.E.S., E-Mycin, others), troleandomycin (TAO), and sparfloxacin
(Zagam); antidepressants such as amitriptyline (Elavil), maprotiline (Ludiomil), and nefazodone
(Serzone); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and
ketoconazole (Nizoral); phenothiazines such as prochlorperazine (Compazine, others) and
promethazine (Phenergan, others); antihistamines such as astemizole (Hismanal); blood pressure
medications such as bepridil (Vascor); heart medications such as procainamide (Procan SR, Procanbid,
Pronestyl) and quinidine (Quinidex, Quinaglute); and HIV medications such as indinavir (Crixivan) and
ritonavir (Norvir). Taken with any of these drugs, cisapride may cause irregular heartbeats that could
lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart
problems. Talk to your doctor or pharmacist before taking any other medications.
The effects of cisapride may be decreased by drugs such as clidinium (Quarzan), dicyclomine
(Bentyl), hyoscyamine (Levsin, Cystospaz, Anaspaz), belladonna (Donnatal), and propantheline
(Pro-Banthine).
Cimetidine (Tagamet, Tagamet HB) may increase the level of cisapride in your body. Talk to
your doctor before taking cimetidine during treatment with cisapride.
Warfarin (Coumadin) may have increased effects during treatment with cisapride. This could
lead to bleeding. Your doctor may need to make adjustments to your warfarin dosage.
Use other medications cautiously during treatment with cisapride to avoid harming yourself
or others. Excessive drowsiness may result if benzodiazepines such as alprazolam (Xanax), diazepam
(Valium), chlordiazepoxide (Librium), and temazepam (Restoril) are taken during cisapride therapy.
Drugs other than those listed here may also interact with cisapride. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter medicines.