Ticlopidine keeps the platelets in your blood from coagulating (clotting) to prevent unwanted
blood clots that can occur with certain heart or blood vessel conditions.
Ticlopidine is used to prevent blood clots after a recent heart attack or stroke, and in people
with certain disorders of the heart or blood vessels.
Ticlopidine may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking ticlopidine (oral)?
You should not use this medication if you are allergic to ticlopidine, or if you have:
severe liver disease;
any active bleeding such as a stomach ulcer or bleeding in
the brain (such as from a head injury); or
a blood cell disorder such as anemia (lack of red blood
cells) or low levels of platelets (cells that help your blood clot).
If you have any of these other conditions, you may need a dose adjustment
or special tests to safely take ticlopidine:
a bleeding or blood clotting disorder, such as hemophilia;
a history of stroke, including TIA ("mini-stroke");
a stomach ulcer or ulcerative colitis;
high cholesterol or triglycerides;
liver disease; or
kidney disease.
FDA pregnancy category B. This medication is not expected to be
harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during
treatment.
It is not known whether ticlopidine passes into breast milk or if it could harm a nursing
baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take ticlopidine (oral)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
amounts, or take it for longer than recommended by your doctor. Follow the directions on your
prescription label.
Take this medication with a full glass of water.
Take ticlopidine with food.
Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood
clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek
emergency medical attention if you have bleeding that will not stop.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a
regular basis. Do not miss any scheduled visits to your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using
ticlopidine.
Store ticlopidine at room temperature away from moisture and heat.
What happens if I miss a dose of ticlopidine (oral)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait
until then to take the medicine and skip the missed dose.
Do not
take extra medicine
to make up the missed dose.
Where can I get more information about ticlopidine (oral)?
Your pharmacist has information about ticlopidine (oral) written for health professionals that you may read.
What are the possible side effects of ticlopidine (oral)?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using ticlopidine and call your doctor at once if you have a serious side effect such as:
nosebleed or other bleeding that will not stop;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
chest pain or heavy feeling, pain spreading to the arm or
shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the
body;
sudden headache, confusion, problems with vision, speech,
or balance; or
pale skin, easy bruising or bleeding, weakness, fever, and
urinating more or less than usual;
signs of infection such as fever, chills, sore throat, flu
symptoms, mouth sores; or
nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
upset stomach, nausea, or vomiting;
ringing in your ears;
diarrhea;
dizziness; or
itching.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
What is the most important information I should know about ticlopidine (oral)?
You should not use this medication if you are allergic to ticlopidine, or if you have severe
liver disease, any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head
injury), or a blood cell disorder such as anemia (lack of red blood cells) or low levels of platelets (cells
that help your blood clot).
Before taking ticlopidine, tell your doctor if you have a bleeding or blood clotting disorder, a
history of stroke, including TIA ("mini-stroke"), a stomach ulcer or ulcerative colitis, high cholesterol or
triglycerides, liver disease, or kidney disease.
Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood
clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek
emergency medical attention if you have bleeding that will not stop.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using
ticlopidine.
While you are taking ticlopidine, do not take aspirin or other NSAIDs (non-steroidal
anti-inflammatory drugs) such as ibuprofen (Advil, Motrin) without your doctor's advice.
Taking ticlopidine with certain other drugs can increase your risk of bleeding. Before taking
ticlopidine, tell your doctor about all other medications you use.
What should I avoid while taking ticlopidine (oral)?
While you are taking ticlopidine, do not take aspirin or other NSAIDs (non-steroidal
anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil),
naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine),
flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic
acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.
Avoid sports or activities that could result in a bruising or bleeding injury. Use extra caution to
avoid cuts when brushing your teeth or shaving.
Avoid drinking alcohol while taking ticlopidine. Alcohol may increase your risk of bleeding
in your stomach or intestines.
What other drugs will affect ticlopidine (oral)?
Taking ticlopidine with certain other drugs can increase your risk of bleeding. Before taking
ticlopidine, tell your doctor if you also take:
aspirin;
warfarin (Coumadin);
heparin, ardeparin (Normiflo), dalteparin (Fragmin),
danaparoid (Orgaran), or enoxaparin (Lovenox);
clopidogrel (Plavix);
dipyridamole (Persantine); or
an NSAID (non-steroidal anti-inflammatory drug) such as
ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren),
etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Tell your doctor about all other medications you use, especially:
antacids or cimetidine (Tagamet, Tagamet HB);
digoxin (Lanoxin, Lanoxicaps);
theophylline (Elixophyllin, Theo-24, Uniphyl); or
phenytoin (Dilantin).
This list is not complete and there may be other drugs that can interact with
ticlopidine. Tell your doctor about all your prescription and over-the-counter medications, vitamins,
minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication
without telling your doctor.
What happens if I have an overdose of ticlopidine (oral)?
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate,
up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not
warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does
not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist
licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not
a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any
given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug
interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
or pharmacist.
Content provided by Multum - Last Updated 11/10/2009