What is zileuton?
Zileuton is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body
releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs
and tightening of the muscles around your airways, which can result in asthma symptoms.
Zileuton is used to prevent asthma attacks in adults and children as young as 12 years old.
Zileuton may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking zileuton?
Do not use this medication if you are allergic to zileuton, or if you have liver disease.
If you drink large amounts of alcohol or have a history of liver disease, you may need a dose
adjustment or special tests to safely take zileuton
FDA pregnancy category C. It is not known whether zileuton is harmful to an unborn baby.
Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during
treatment.
It is not known whether zileuton passes into breast milk or if it could harm a nursing baby. .
Do not take zileuton without telling your doctor if you are breast-feeding a baby.
Do not give this medication to a child without a doctor's advice.
How should I take zileuton?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
amounts, or take it for longer than recommended by your doctor. Follow the directions on your
prescription label.
Take zileuton with a full glass of water.
Zileuton
tablets
and
extended-release tablets
contain
the same amount of the drug, but they are not taken in the same way. Follow your doctor's
instructions.
Zileuton
tablets
are usually taken 4 times daily, with meals and at bedtime.
Zileuton tablets may be swallowed whole or split in half to make swallowing easier.
Zileuton
extended-release tablets
are usually taken twice daily, within 1
hour after your morning and evening meals.
Do not crush, chew, or break an
extended-release tablet
. Swallow the
pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause
too much of the drug to be released at one time.
Do not use zileuton to treat an asthma attack that has already begun. It will not work fast
enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an asthma
attack. Talk with your doctor if any of your asthma medications do not seem to work as well in treating
or preventing asthma attacks.
It may take up to a few weeks of using this medicine before your symptoms improve. For
best results, keep using zileuton as directed, even if you feel fine. Having no asthma symptoms is a sign
that the medication is working.
Asthma is often treated with a combination of different drugs. To best treat your condition, use
all of your medications as directed by your doctor. Be sure to read the medication guide or patient
instructions provided with each of your medications. Do not change your doses or medication schedule
without advice from your doctor, even if you have no asthma symptoms.
Call your doctor right away if you feel that this medicine is not working as well as usual, or if it
makes your condition worse. If it seems like you need to use more of any of your medications in a
24-hour period, talk with your doctor.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a
regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled
visits to your doctor.
Store zileuton at room temperature away from moisture and heat.
What happens if I miss a dose of zileuton?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at your next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about zileuton?
Your pharmacist has information about zileuton written for health professionals that you may read.
What are the possible side effects of zileuton?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
-
nausea, stomach pain, low fever, loss of appetite, dark urine,
clay-colored stools, jaundice (yellowing of the skin or eyes);
-
skin rash, bruising, severe tingling, numbness, pain, muscle
weakness;
-
mood or behavior changes, anxiety, depression, or thoughts
about suicide or hurting yourself; or
-
worsening asthma symptoms.
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088.
What is the most important information I should know about zileuton?
Call your doctor at once if you have nausea, stomach pain, low fever, loss of appetite, dark
urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These may be early signs of liver
problems.
Do not use zileuton to treat an asthma attack that has already begun. It will not work fast
enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an asthma
attack. Talk with your doctor if any of your asthma medications do not seem to work as well in treating
or preventing asthma attacks.
It may take up to a few weeks of using this medicine before your symptoms improve. For
best results, keep using zileuton as directed, even if you feel fine. Having no asthma symptoms is a sign
that the medication is working.
Call your doctor right away if you feel that this medicine is not working as well as usual, or if it
makes your condition worse. If it seems like you need to use more of any of your medications in a
24-hour period, talk with your doctor.
Avoid drinking alcohol while you are taking zileuton. Alcohol can increase your risk of liver
damage.
Call your doctor at once if you have any mood or behavior changes, anxiety, depression, or
thoughts about suicide or hurting yourself.
What should I avoid while taking zileuton?
Avoid situations or activities that may trigger an asthma attack.
Avoid drinking alcohol while taking zileuton. Alcohol may increase your risk of liver
damage.
What other drugs will affect zileuton?
Before taking zileuton, tell your doctor if you are taking any of the following drugs:
-
a blood thinner such as warfarin (Coumadin);
-
theophylline (Theo-Dur, Theolair, Elixophyllin, Slo-Phyllin,
others); or
-
propranolol (Inderal).
This list is not complete and there may be other drugs that can interact with
zileuton. Tell your doctor about all the prescription and over-the-counter medications you use. This
includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using
a new medication without telling your doctor.
What happens if I have an overdose of zileuton?