Anthrax is a disease caused by infection with a spore-forming bacteria. It usually occurs in
animals such as sheep, goats, cattle, deer, antelope, and other herbivores. Anthrax can also occur in
people who are exposed to an infected animal or other source of the anthrax bacteria.
Anthrax is spread to a human through the skin, the stomach, or the lungs. The bacteria can
enter the skin through a cut or wound that comes into contact with products from an infected animal
(such as meat, wool, hide, or hair). Infection can also occur through the lungs when a person inhales
the bacterial spore, or through the stomach when a person eats undercooked meat from an infected
animal.
Anthrax is most common in agricultural regions lacking in good veterinary prevention programs,
especially in Africa, Asia, Central and South America, the Carribean, the Middle East and Southeastern
Europe. Although less common, anthrax does occur in the United States each year among both wild
game animals and domestic livestock.
Anthrax is a serious disease that can spread quickly throughout the body and it is fatal in a high
number of cases, especially when acquired through the lungs.
The anthrax vaccine is used to help prevent this disease in people exposed to the bacteria
through the skin or lungs. This vaccine works by exposing you to an antigen protein that causes your
body to develop immunity to the disease. Anthrax vaccine does not contain live or killed forms of the
bacteria that causes anthrax.
Anthrax vaccine will not treat an active infection that has already developed in the body.
Like any vaccine, the anthrax vaccine may not provide protection from disease in every person.
What should I discuss with my healthcare provider before taking anthrax vaccine?
You should not receive this vaccine if you have ever had a life-threatening allergic reaction
to an anthrax vaccine, or if you have ever had anthrax disease acquired through the skin.
Before receiving this vaccine, tell the doctor if you have ever had an allergic reaction to any type
of vaccine, or if you have:
an allergy to latex rubber;
a weak immune system caused by disease (such as cancer,
HIV, or AIDS), or by taking certain medicines;
if you have received cancer chemotherapy, radiation
treatment, or steroid medications in the past 3 months.
You can still receive a vaccine if you have a cold or mild fever. In the case
of a more severe illness with a high fever or any type of infection, wait until you get better before
receiving this vaccine.
Vaccines generally should not be given to a pregnant woman. However, not vaccinating the
mother could be more harmful to the baby if the mother becomes infected with a disease that this
vaccine could prevent. Your doctor will decide whether you should receive this vaccine, especially if
you have a high risk of infection with anthrax.
How should I take anthrax vaccine?
This vaccine is given as an injection (shot) under the skin. You will receive this injection in a
doctor's office or other clinic setting.
Anthrax vaccine is recommended for adults in the following situations:
people who handle anthrax bacteria in a laboratory or other work
setting;
people who handle animal hides or furs imported from
areas where anthrax is common;
people who handle meat or other animal products in areas
where anthrax is common;
veterinarians who travel to countries where anthrax is
common; and
military personnel at risk of exposure through potential
biological warfare when anthrax may be used as a weapon.
The anthrax vaccine is given in a series of 6 shots. The first 3 shots are given
2 weeks apart. The following three 3 shots are given 6, 12, and 18 months after the first shot. An
annual booster shot is then recommended every year during possible exposure to anthrax. Your
individual booster schedule may be different from these guidelines. Follow your doctor's instructions or
the schedule recommended by the health department of the state where you live.
You may receive anthrax vaccine at the same time as other vaccines.
What happens if I miss a dose of anthrax vaccine?
Contact your doctor if you will miss a booster dose or if you get behind schedule. The next
dose should be given as soon as possible. There is no need to start over.
Be sure you receive all recommended doses of this vaccine. If you do not receive the full series
of vaccines, you may not be fully protected against the disease.
Where can I get more information about anthrax vaccine?
Your pharmacist has information about anthrax vaccine written for health professionals that you may read.
What are the possible side effects of anthrax vaccine?
You should not receive a booster vaccine if you had a life-threatening allergic reaction after
the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you
receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with anthrax is much more dangerous to your health than receiving the
vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of
serious side effects is extremely low.
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect (some are rare but serious) such as:
severe swelling or a hard lump where the shot was given;
severe swelling spreading to other parts of your arm;
fever, chills, body aches, nausea, flu symptoms;
pale skin, easy bruising or bleeding;
confusion, changes in mood or behavior;
seizure (convulsions);
blistering, redness, and swelling or warmth of the skin;
weakness, numbness or tingly feeling in your feet spreading
upward;
problems with vision, hearing, speech, swallowing, or
bladder and bowel functions;
severe lower back pain; or
slow heart rate, trouble breathing, weak pulse, or feeling
like you might pass out.
Less serious side effects include:
mild redness, warmth, itching, or tenderness where the shot was
given;
low fever;
feeling tired or weak;
headache, dizziness;
mild pain or stiffness in the injected arm;
joint or muscle pain;
swelling in your hands or feet; or
mild skin rash.
This is not a complete list of side effects and others may occur. Tell your
doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about anthrax vaccine?
You should not receive this vaccine if you have ever had a life-threatening allergic reaction
to an anthrax vaccine, or if you have ever had anthrax disease acquired through the skin.
You can still receive a vaccine if you have a cold or mild fever. In the case of a more severe
illness with a high fever or any type of infection, wait until you get better before receiving this vaccine.
Before receiving anthrax vaccine, tell the doctor about all other vaccines you have recently
received. Also tell the doctor if you have recently received drugs or treatments that can weaken the
immune system, such as steroids, psoriasis or arthritis medications, medicines to treat or prevent organ
transplant rejection, or chemotherapy or radiation treatments. You may not be able to receive the
anthrax vaccine, or may need to wait until the other treatments are finished.
Becoming infected with anthrax is much more dangerous to your health than receiving the
vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of
serious side effects is extremely low.
Anthrax vaccine will not treat an active infection that has already developed in the body.
What should I avoid while taking anthrax vaccine?
Follow your doctor's instructions about any restrictions on food, beverages, or activity after you
receive this vaccine.
What other drugs will affect anthrax vaccine?
Before receiving this vaccine, tell the doctor about all other vaccines you have recently
received.
Also tell the doctor if you have recently received drugs or treatments that can weaken the
immune system, including:
an oral, nasal, inhaled, or injectable steroid medicine;
medications to treat psoriasis, rheumatoid arthritis, or
other autoimmune disorders, such as azathioprine (Imuran), efalizumab (Raptiva), etanercept
(Enbrel), leflunomide (Arava), and others; or
medicines to treat or prevent organ transplant rejection,
such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab-CD3
(Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).
If you are using any of these medications, you may not be able to receive the
vaccine, or may need to wait until the other treatments are finished.
There may be other drugs that can affect the anthrax vaccine. Tell your doctor about all the
prescription and over-the-counter medications you have received. This includes vitamins, minerals,
herbal products, and drugs prescribed by other doctors. While you are receiving the anthrax vaccine
series, do not start using a new medication without telling your doctor.
What happens if I have an overdose of anthrax vaccine?
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate,
up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not
warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does
not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist
licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not
a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any
given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug
interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
or pharmacist.
Content provided by Multum - Last Updated 11/10/2009