Cisplatin is an antineoplastic medication. Cisplatin interferes with the growth of cancer cells and
slows their growth and spread in the body.
Cisplatin is used to treat various types of cancer including metastatic testicular tumors,
metastatic ovarian tumors, and advanced bladder cancer.
Cisplatin may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking cisplatin?
Do not use cisplatin without first talking to your doctor if you have
kidney disease;
poor bone marrow function;
hearing impairment; or
an allergy to platinum or platinum-containing products.
The use of cisplatin may be dangerous if you have any of the conditions
listed above.
Cisplatin is in the FDA pregnancy category D. This means that cisplatin is known to be
harmful to an unborn baby.
Do not
use cisplatin without first talking to your doctor if
you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with
cisplatin if necessary.
Cisplatin passes into breast milk and may harm a nursing baby. Breast-feeding should be
avoided during treatment with cisplatin.
How should I take cisplatin?
Cisplatin should only be administered under the supervision of a qualified healthcare provider
experienced in the use of cancer chemotherapeutic agents.
Your doctor will determine the correct amount and frequency of treatment with cisplatin
depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any
questions or concerns regarding the treatment schedule.
Adequate hydration is important during treatment with cisplatin. Your doctor may prescribe
the administration of intravenous fluids and/or recommend additional fluid intake by mouth during
treatment.
Your doctor will probably want you to have regularly scheduled blood tests and other medical
evaluations during treatment with cisplatin to monitor progress and side effects.
Your healthcare provider will store cisplatin as directed by the manufacturer. If you are storing
cisplatin at home, follow the directions provided by your healthcare provider.
What happens if I miss a dose of cisplatin?
Contact your doctor if you miss a dose of cisplatin.
Where can I get more information about cisplatin?
Your pharmacist has information about cisplatin written for health professionals that you may read.
What are the possible side effects of cisplatin?
If you experience all of the following serious side effects from cisplatin, contact your doctor
immediately:
an allergic reaction (including difficulty breathing; closing of the
throat; swelling of the lips, tongue, or face; or hives);
kidney damage (little or no urine production, blood in the
urine);
hearing loss or ringing in the ears;
decreased bone marrow function and blood problems
(extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or
signs of infection);
severe nausea, vomiting, diarrhea, and loss of appetite;
heart and circulation problems;
gout or increased uric acid in the blood;
numbness or tingling;
blurred vision, altered color perception, blindness, and
other visual problems;
liver damage (abdominal pain, yellowing of the skin or
eyes); or
hair loss.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about cisplatin?
Cisplatin should only be administered under the supervision of a qualified healthcare provider
experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of cisplatin including: allergic reactions
(difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); kidney damage
(little or no urine production, blood in the urine); hearing loss or ringing in the ears; decreased bone
marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry
stools; or fever, chills, or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and
others. Talk to your doctor about the possible side effects from treatment with cisplatin.
What should I avoid while taking cisplatin?
There are no restrictions on food, beverages, or activity while using cisplatin unless otherwise
directed by your doctor.
What other drugs will affect cisplatin?
Before using cisplatin, tell your doctor if you are using any of the following medicines to control
seizures:
carbamazepine (Tegretol, Carbatrol, Epitol);
phenytoin (Dilantin);
gabapentin (Neurontin);
tiagabine (Gabitril);
valproic acid (Depakene) or divalproex sodium (Depakote);
lamotrigine (Lamictal);
felbamate (Felbatol);
levetiracetam (Keppra);
primidone (Mysoline);
zonisamide (Zonegran);
topiramate (Topamax);
oxcarbazepine (Trileptal);
a barbiturate such as mephobarbital (Mebaral) or
pentobarbital (Nembutal); or
a benzodiazepine such as lorazepam (Ativan), diazepam
(Diastat, Valium), clonazepam (Klonopin), or clorazepate (Tranxene).
Cisplatin may decrease the effects of medicines used to control seizures and
a dosage adjustment may be required.
Drugs other than those listed here may also interact with cisplatin. Talk to your doctor and
pharmacist before taking any other prescription or over-the-counter medicines, including herbal
products, during treatment with cisplatin.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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Content provided by Multum - Last Updated 11/10/2009