Clomiphene stimulates the release of hormones necessary for ovulation to occur.
Clomiphene is used to stimulate ovulation (the release of an egg) when a woman's ovaries
can produce a follicle but hormonal stimulation is deficient.
Clomiphene may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking clomiphene?
Do not take clomiphene without first talking to your doctor if you
might be pregnant;
have a thyroid problem or another endocrine disorder;
have undiagnosed vaginal bleeding;
have endometriosis or endometrial carcinoma;
have uterine fibroids;
have liver disease;
have ovarian cysts or ovarian enlargement not due to
polycystic ovarian syndrome; or
have any other serious or chronic medical illness.
You may not be able to take clomiphene, or you may require a lower
dose or special monitoring if you have any of the conditions listed above.
Do not
take clomiphene if you are pregnant. Clomiphene is in the
FDA pregnancy category X. This means that it is known to cause birth defects.
It is not known whether clomiphene pass into breast milk. Do not take clomiphene
without first talking to your doctor if you are breast-feeding a baby.
How should I take clomiphene?
Use clomiphene exactly as directed by your doctor. If you do not understand these directions,
ask your doctor, nurse, or pharmacist to explain them to you.
Take each dose with a full glass of water.
Clomiphene is usually taken in 5 day cycles. Follow your doctor's instructions.
Store clomiphene at room temperature, away from direct light, moisture, and heat.
What happens if I miss a dose of clomiphene?
Contact your doctor if you miss a dose of clomiphene.
Where can I get more information about clomiphene?
Your pharmacist has information about clomiphene written for health professionals that you may read.
What are the possible side effects of clomiphene?
Stop taking clomiphene and seek emergency medical attention if you experience an
allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face;
or hives).
The ovarian hyperstimulation syndrome (OHSS) has been reported to occur in patients
receiving clomiphene. Symptoms of OHSS include swelling of the hands or legs, abdominal pain
and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal. Notify
your doctor immediately or seek emergency medical attention if you develop any of these side
effects.
Other side effects may also occur. Notify your doctor if you experience
ovarian enlargement presenting as abdominal or pelvic pain,
tenderness, pressure, or swelling;
flushing;
nausea, vomiting, or diarrhea;
breast tenderness or discomfort;
blurred vision or other visual disturbances;
headache; or
abnormal uterine bleeding.
Clomiphene may increase the likelihood of multiple births. Multiple
births may carry additional risk both for the mother and for the fetuses.
Side effects other than those listed here may also occur. Talk to your doctor about any side
effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about clomiphene?
Use caution when driving, operating machinery, or performing other hazardous
activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after
therapy. Notify your doctor immediately if you develop any visual side effects and use caution when
performing hazardous activities, especially under conditions of variable lighting.
Clomiphene may increase the likelihood of multiple births. Multiple births may carry
additional risk both for the mother and for the fetuses.
What should I avoid while taking clomiphene?
Use caution when driving, operating machinery, or performing other hazardous
activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after
therapy. Notify your doctor immediately if you develop any visual side effects and use caution when
performing hazardous activities, especially under conditions of variable lighting.
What other drugs will affect clomiphene?
There are no known interactions between clomiphene and other medicines. Talk to your
doctor and pharmacist before taking any prescription or over-the-counter medicines.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate,
up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not
warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does
not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist
licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not
a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any
given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug
interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
or pharmacist.
Content provided by Multum - Last Updated 11/10/2009