What is hydrochlorothiazide and quinapril?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from
absorbing too much salt, which can cause fluid retention.
Quinapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting
enzyme. Quinapril lowers blood pressure and also relieves symptoms of fluid retention.
The combination of hydrochlorothiazide and quinapril is used to treat hypertension (high blood
pressure).
Hydrochlorothiazide and quinapril may also be used for other purposes not listed in this
medication guide.
What should I discuss with my healthcare provider before taking hydrochlorothiazide and quinapril?
Do not use this medication if you are allergic to hydrochlorothiazide or quinapril, or if you
are unable to urinate.
You should not use this medication if you are allergic to other ACE inhibitor, such as benazepril
(Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril),
moexipril (Univasc), perindopril (Aceon), ramipril (Altace), or trandolapril (Mavik).
If you have certain conditions, you may need a dose adjustment or special tests to safely take
this medication. Before you take hydrochlorothiazide and quinapril, tell your doctor if you have:
-
kidney disease (or if you are on dialysis);
-
liver disease;
-
congestive heart failure;
-
gout;
-
lupus;
-
diabetes; or
-
an allergy to sulfa drugs.
FDA pregnancy category D.
Do not
use this
medication without telling your doctor if you are pregnant or planning a pregnancy. Quinapril could
cause birth defects in the baby if you take the medication during pregnancy. Use an effective form of
birth control. Stop using this medication and tell your doctor right away if you become pregnant during
treatment.
Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use
this medication without telling your doctor if you are breast-feeding a baby.
How should I take hydrochlorothiazide and quinapril?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
amounts, or take it for longer than recommended by your doctor. Follow the directions on your
prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this
medication.
Take each dose with a full glass of water.
Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea,
heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow
your doctor's instructions about the type and amount of liquids you should drink while taking
hydrochlorothiazide and quinapril. Tell your doctor if you have a prolonged illness that causes diarrhea
or vomiting.
While you are taking this medication, your blood pressure will need to be checked on a regular
basis. Do not miss any scheduled appointments.
Your blood and urine may also be tested if you have been vomiting or are dehydrated.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats
you that you are using a thiazide diuretic.
If you are being treated for high blood pressure, keep using this medication even if you feel fine.
High blood pressure often has no symptoms.
Store hydrochlorothiazide and quinapril at room temperature away from moisture, heat, and
light.
What happens if I miss a dose of hydrochlorothiazide and quinapril?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at the next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about hydrochlorothiazide and quinapril?
Your pharmacist has information about hydrochlorothiazide and quinapril written for health professionals that you may read.
What are the possible side effects of hydrochlorothiazide and quinapril?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue,
or throat.
Call your doctor at once if you have any of these serious side effects:
-
high potassium (slow heart rate, weak pulse, muscle weakness,
tingly feeling);
-
low potassium (confusion, uneven heart rate, extreme
thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
-
dry mouth, thirst, nausea, vomiting;
-
feeling weak, drowsy, restless, or light-headed;
-
a red, blistering, peeling skin rash;
-
jaundice (yellowing of the skin or eyes);
-
urinating less than usual or not at all;
-
swelling, weight gain, feeling short of breath; or
-
fever, chills, body aches, flu symptoms.
Less serious side effects may include:
-
cough;
-
dizziness, headache, tired feeling;
-
muscle or back pain;
-
runny nose;
-
sleep problems (insomnia);
-
diarrhea, constipation, upset stomach; or
-
mild skin rash, increased sweating.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about hydrochlorothiazide and quinapril?
Do not use this medication if you are unable to urinate.
You should not use this medication if you are allergic to any other ACE inhibitor, such as
benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil,
Zestril), moexipril (Univasc), perindopril (Aceon), ramipril (Altace), or trandolapril (Mavik).
Before taking hydrochlorothiazide and quinapril, tell your doctor if you have kidney disease (or
are on dialysis), liver disease, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs.
Quinapril can cause birth defects in the baby if you take the medication during pregnancy.
Do not
use hydrochlorothiazide and quinapril without telling your doctor if you are
pregnant or planning a pregnancy.
Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements
while taking hydrochlorothiazide and quinapril, unless your doctor has told you to.
Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea,
heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow
your doctor's instructions about the type and amount of liquids you should drink while taking
hydrochlorothiazide and quinapril. Tell your doctor if you have a prolonged illness that causes diarrhea
or vomiting.
What should I avoid while taking hydrochlorothiazide and quinapril?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your
doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking
too much liquid can be as unsafe as not drinking enough.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly
and steady yourself to prevent a fall.
Avoid drinking alcohol, which can increase some of the side effects of hydrochlorothiazide
and quinapril.
Avoid using other medicines that make you light-headed (such as cold medicine, pain
medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to the side
effects of hydrochlorothiazide and quinapril. Tell your doctor if you regularly use any of these
medicines, or any other blood pressure medications.
Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements
while taking hydrochlorothiazide and quinapril, unless your doctor has told you to.
What other drugs will affect hydrochlorothiazide and quinapril?
Before taking this medication, tell your doctor if you are using any of the following drugs:
-
other diuretics (water pills) or blood pressure medications;
-
gold injections to treat arthritis;
-
lithium (Lithobid, Eskalith);
-
a tetracycline antibiotic such as demeclocycline
(Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin,
Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
-
digoxin (Lanoxin);
-
cholestyramine (Prevalite, Questran) or colestipol
(Colestid);
-
steroids (prednisone and others);
-
a tetracycline antibiotic such as demeclocycline
(Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin,
Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
-
NSAIDs (non-steroidal anti-inflammatory drugs) such as
aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve,
Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or
-
insulin or diabetes medicine taken by mouth.
This list is not complete and there may be other drugs that can interact with
hydrochlorothiazide and quinapril. Tell your doctor about all the prescription and over-the-counter
medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start using a new medication without telling your doctor.
What happens if I have an overdose of hydrochlorothiazide and quinapril?
