What should I avoid while taking isoniazid, pyrazinamide, and rifampin?
Do not wear contact lenses while taking isoniazid, pyrazinamide, and rifampin. Rifampin may
turn your tears, sweat, saliva, urine, feces, and contact lenses a red-orange color. This effect may be
permanent on contact lenses.
This medicine may decrease the effectiveness of birth control pills. Talk to your doctor
about using another form of birth control during treatment with isoniazid, pyrazinamide, and rifampin to
prevent pregnancy.
Avoid alcohol while taking isoniazid, pyrazinamide, and rifampin. Alcohol will increase the
risk of damage to your liver during treatment with this medication.
Use caution with the foods listed below. They can interact with isoniazid, pyrazinamide, and
rifampin and cause a reaction that includes a severe headache, large pupils, neck stiffness, nausea,
vomiting, diarrhea, flushing, sweating, itching, irregular heartbeats, and chest pain. A reaction will not
necessarily occur, but eat these foods with caution until you know if you will react to them. Call your
doctor immediately if you experience any of these symptoms.
Eat the following foods with caution:
-
cheeses, including American, blue, boursault, brick, brie,
camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton,
and Swiss;
-
sour cream and yogurt;
-
beef or chicken liver, fish, meats prepared with tenderizer,
bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish,
herring, shrimp paste, and tuna;
-
avocados, bananas, figs, raisins, and sauerkraut;
-
soy sauce, miso soup, bean curd, and fava beans;
-
yeast extracts;
-
ginseng;
-
chocolate;
-
caffeine (coffee, tea, cola, etc.); and
-
beer (alcoholic and nonalcoholic), red wine (especially
Chianti), sherry, vermouth, and other distilled spirits.
What other drugs will affect isoniazid, pyrazinamide, and rifampin?
Before taking isoniazid, pyrazinamide, and rifampin, tell your doctor if you are taking any of the
following drugs:
-
antacids. Aluminum salts will decrease the action of isoniazid. Do
not take antacids that contain aluminum for 1 to 2 full hours before or after taking a dose of
isoniazid.
-
allopurinol (Zyloprim). The effects of allopurinol may be
decreased by pyrazinamide.
-
ketoconazole (Nizoral), itraconazole (Sporanox), or
fluconazole (Diflucan). Isoniazid, pyrazinamide, and rifampin may decrease the action of the
antifungal medicines. Therefore, a fungal infection may not be adequately treated.
-
disulfiram (Antabuse). Unusual behavior and coordination
difficulties may occur if these medicines are taken together.
Isoniazid may increase the effects of the following medicines:
-
warfarin (Coumadin);
-
carbamazepine (Tegretol);
-
theophylline (Theo-Dur, Theochron, Theolair, Slo-Phyllin,
Elixophyllin);
-
ethionamide (Trecator-SC);
-
cycloserine (Seromycin);
-
phenytoin (Dilantin), ethotoin (Peganone), and
mephenytoin (Mesantoin);
-
meperidine (Demerol); and
-
benzodiazepines such as alprazolam (Xanax), diazepam
(Valium), lorazepam (Ativan), and temazepam (Restoril).
Before taking isoniazid, pyrazinamide, and rifampin, tell your doctor if you
are taking any of the medicines listed above.
Rifampin may decrease the effects of the following drugs:
-
acetaminophen (Tylenol, others);
-
blood thinners such as warfarin (Coumadin);
-
barbiturates such as phenobarbital (Luminal, Solfoton),
amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol);
-
benzodiazepines such as alprazolam (Xanax), diazepam
(Valium), and temazepam (Restoril);
-
beta-blockers such as atenolol (Tenormin), propranolol
(Inderal), and metoprolol (Lopressor);
-
heart medicines such as digoxin (Lanoxin), disopyramide
(Norpace), quinidine (Quinora, Quinidex, Cardioquin, others), mexiletine (Mexitil), tocainide
(Tonocard), verapamil (Calan, Verelan, Isoptin), and enalapril (Vasotec);
-
corticosteroids such as prednisone (Deltasone, Orasone,
Meticorten), prednisolone (Delta Cortef, Prelone, others), methylprednisolone (Medrol), and
betamethasone (Celestone);
-
sulfonylureas such as glipizide (Glucotrol), glyburide
(Micronase, Diabeta, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), and
tolazamide (Tolinase);
-
HIV and AIDS medicines such as zidovudine (Retrovir),
delavirdine (Rescriptor), saquinavir (Invirase), ritonavir (Norvir), indinavir (Crixivan), and
nelfinavir (Viracept);
-
sulfa medicines such as sulfamethoxazole (Bactrim, Septra,
Gantanol, Azo-Gantanol), and sulfisoxazole (Gantrisin, Azo-Gantrisin);
-
estrogens such as Premarin, Ogen, Estrace, Menest,
Estratab, Ortho-Est, and others;
-
oral birth control pills such as Triphasil, Ortho-Novum,
Ortho-Cyclen, Ortho-Tri-Cyclen, Ovral, Lo/Ovral, Desogen, Nordette, Levora, Levlen,
Tri-Levlen, Nelova, Norinyl, Brevicon, Ovcon, Loestrin, Demulen, and others;
-
phenytoin (Dilantin), ethotoin (Peganone), and
mephenytoin (Mesantoin);
-
theophylline (Theolair, Theo-Dur, Theochron, Theo-Bid,
others);
-
methadone (Dolophine);
-
clofibrate (Atromid-S); and
-
cyclosporine (Sandimmune, Neoral).
Pyrazinamide may affect the Acetest and Ketostix urine tests for ketones.
This reaction can cause a pink-brown color to appear.
Drugs other than those listed here may also interact with isoniazid, pyrazinamide, and rifampin.
Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
