Do not wear contact lenses while taking isoniazid and rifampin. Rifampin may turn your
tears, sweat, saliva, urine, feces, and contact lenses a red-orange color. This effect may be
permanent on contact lenses.
This medication may decrease the effectiveness of birth control pills. Talk to your
doctor about using another form of birth control during treatment.
Avoid alcohol while taking isoniazid and rifampin. Alcohol will increase the risk of
damage to your liver during treatment with this medication.
Use caution with the foods listed below. They can interact with isoniazid and rifampin
and cause a reaction that includes a severe headache, large pupils, neck stiffness, nausea,
vomiting, diarrhea, flushing, sweating, itching, irregular heartbeats, and chest. A reaction will not
necessarily occur, but eat these foods with caution until you know if you will react to them. Call
your doctor immediately if you experience any of these symptoms.
-
cheeses, including american, blue, boursault, brick, brie,
camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton,
and swiss;
-
sour cream and yogurt;
-
beef or chicken liver, fish, meats prepared with tenderizer,
bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish,
herring, shrimp paste, and tuna;
-
avocados, bananas, figs, raisins, and sauerkraut;
-
soy sauce, miso soup, bean curd, and fava beans;
-
yeast extracts;
-
ginseng;
-
chocolate;
-
caffeine (coffee, tea, cola, etc.); and
-
beer (alcoholic and nonalcoholic), red wine (especially
Chianti), sherry, vermouth, and other distilled spirits.
Before taking isoniazid and rifampin, tell your doctor if you are taking any of the
following drugs:
-
antacids;
-
ketoconazole (Nizoral), fluconazole (Diflucan), or
itraconazole (Sporanox);
-
disulfiram (Antabuse);
-
warfarin (Coumadin);
-
carbamazepine (Tegretol);
-
cycloserine (Seromycin);
-
phenytoin (Dilantin), ethotoin (Peganone), and
mephenytoin (Mesantoin);
-
meperidine (Demerol);
-
benzodiazepines such as alprazolam (Xanax),
diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril).
-
acetaminophen (Tylenol, others);
-
blood thinners such as warfarin (Coumadin);
-
barbiturates such as phenobarbital (Luminal, Solfoton),
amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol);
-
beta-blockers such as atenolol (Tenormin),
propranolol (Inderal), and metoprolol (Lopressor);
-
heart medicines such as digoxin (Lanoxin), disopyramide
(Norpace), quinidine (Quinora, Quinidex, Cardioquin, others), mexiletine (Mexitil), tocainide
(Tonocard), verapamil (Calan, Verelan, Isoptin), and enalapril (Vasotec);
-
corticosteroids such as prednisone (Deltasone, Orasone,
Meticorten), prednisolone (Delta Cortef, Prelone, others), methylprednisolone (Medrol), and
betamethasone (Celestone);
-
sulfonylureas such as glipizide (Glucotrol), glyburide
(Micronase, Diabeta, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), and
tolazamide (Tolinase);
-
sulfa medicines such as sulfamethoxazole (Bactrim, Septra,
Gantanol, Azo-Gantanol), and sulfisoxazole (Gantrisin, Azo-Gantrisin);
-
the HIV and AIDS medicines delavirdine (Rescriptor),
saquinavir (Invirase), ritonavir (Norvir), indinavir (Crixivan), nelfinavir (Viracept), and
zidovudine (Retrovir);
-
estrogens such as Premarin, Ogen, Estrace, Menest,
Estratab, Ortho-Est, and others;
-
oral birth control pills such as Triphasil, Ortho-Novum,
Ortho-Cyclen, Ortho-Tri-Cyclen, Ovral, Lo/Ovral, Desogen, Nordette, Levora, Levlen,
Tri-Levlen, Nelova, Norinyl, Brevicon, Ovcon, Loestrin, Demulen, and others;
-
phenytoin (Dilantin), ethotoin (Peganone), and
mephenytoin (Mesantoin);
-
theophylline (Theolair, Theo-Dur, Theochron, Theo-Bid,
others);
-
methadone (Dolophine);
-
clofibrate (Atromid-S); or
-
cyclosporine (Sandimmune, Neoral).
You may not be able to take isoniazid and rifampin, or you may
require a dosage adjustment or special monitoring during treatment if you are taking any of the
medicines listed above.
Drugs other than those listed here may also interact with isoniazid and rifampin. Talk to
your doctor and pharmacist before taking any prescription or over-the-counter medicines.