Mechlorethamine is a cancer (antineoplastic) medication. Mechlorethamine interferes with the
growth of cancer cells and slows their growth and spread in the body.
Mechlorethamine is used to treat several types of cancer, such as Hodgkin's Disease,
lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, lung cancer and mycosis
fungoides. Mechlorethamine is also used to treat certain other blood disorders (polycythemia vera) and
is sometimes injected into body spaces, such as the chest, abdomen or the sack containing the heart, to
stop the accumulation of fluids caused by cancer.
Mechlorethamine may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking mechlorethamine?
Before taking mechlorethamine, tell your doctor if you
have had recent vaccinations;
have any type of infection;
have bone marrow problems;
have had radiation or x-ray therapy; or
have been treated with other cancer (chemotherapy)
medicines.
You may not be able to take mechlorethamine, or you may require a dosage
adjustment or special monitoring during treatment if you have any of the conditions listed above.
Mechlorethamine is in the FDA pregnancy category D. This means that mechlorethamine is
known to cause birth defects in an unborn baby.
Do not
take mechlorethamine
without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Contraceptive measures are recommended during treatment with mechlorethamine.
It is not known whether mechlorethamine passes into breast milk.
Do not
take mechlorethamine without first talking to your doctor if you are breast feeding a baby.
How should I take mechlorethamine?
Mechlorethamine should only be administered under the supervision of a qualified healthcare
provider experienced in the use of cancer chemotherapeutic agents.
Your doctor will determine the correct amount and frequency of treatment with
mechlorethamine depending upon the type of cancer being treated and other factors. Talk to your
doctor if you have any questions or concerns regarding the treatment schedule.
Your doctor will probably want you to have regularly scheduled blood tests and other medical
evaluations during treatment with mechlorethamine to monitor progress and side effects.
Mechlorethamine is highly toxic and both the powder and solution must be handled with care.
Inhalation of dust or vapors and contact with skin or mucous membranes (eyes, nose and mouth) must
be avoided. Should accidental contact occur, rinse the area with water and seek emergency medical
attention.
Your healthcare provider will store mechlorethamine as directed by the manufacturer.
What happens if I miss a dose of mechlorethamine?
Contact your doctor if you miss a dose of mechlorethamine injection.
Where can I get more information about mechlorethamine?
Your pharmacist has information about mechlorethamine written for health professionals that you may read.
What are the possible side effects of mechlorethamine?
If you experience any of the following serious side effects, seek emergency medical
attention or contact your doctor immediately:
an allergic reaction (shortness of breath; closing of your throat;
difficulty breathing; swelling of your lips, face, or tongue; or hives);
blood in the urine;
black or tarry stools;
signs of infection such as fever; chills, or sore throat;
joint pain and stiffness similar to gout (high levels of uric
acid in the blood);
jaundice (yellowing of the skin or eyes);or
unusual bleeding or bruising.
Other less serious side effects may be more likely to occur. Talk to your
doctor if you experience:
nausea, vomiting, or decreased appetite;
mouth sores;
a sensation of spinning or dizziness (vertigo);
diarrhea;
temporary hair loss;
rash;
a ringing in the ears or decreased ability to hear; or
weakness.
In some cases, second malignancies have been reported to occur during and
following treatment with mechlorethamine. Talk to your doctor about the risks and benefits of this
medication.
Side effects other than those listed here may also occur. Talk to your doctor about any side
effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about mechlorethamine?
Mechlorethamine should only be administered under the supervision of a qualified healthcare
provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of mechlorethamine including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding;
black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat);
severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the
possible side effects from treatment with mechlorethamine.
Mechlorethamine is highly toxic and both the powder and solution must be handled with care.
Inhalation of dust or vapors and contact with skin or mucous membranes (eyes, nose and mouth) must
be avoided.
What should I avoid while taking mechlorethamine?
Mechlorethamine can lower the activity of your immune system making you susceptible to
infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not
receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with
mechlorethamine. In addition, avoid contact with individuals who have recently been vaccinated with a
live vaccine. There is a chance that the virus can be passed on to you.
Mechlorethamine is highly toxic and both the powder and solution must be handled with care.
Inhalation of dust or vapors and contact with skin or mucous membranes (eyes, nose and mouth) must
be avoided.
What other drugs will affect mechlorethamine?
Do not receive "live" vaccines during treatment with mechlorethamine. Administration of a
live vaccine may be dangerous during treatment with mechlorethamine.
Other drugs may interact with mechlorethamine. Talk to your doctor and pharmacist before
taking any other prescription or over-the-counter medicines, including herbal products, during treatment
with mechlorethamine.
What happens if I have an overdose of mechlorethamine?
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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Content provided by Multum - Last Updated 11/10/2009