What is mefloquine?
Mefloquine is an antimalarial drug. The exact way that mefloquine works is unknown.
Mefloquine is used in the treatment and prevention of malaria.
Mefloquine may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking mefloquine?
Do not take mefloquine without first talking to your doctor if you have a history of
depression, an anxiety disorder, psychosis, schizophrenia, another major psychiatric disorder, or
seizures.
Before taking mefloquine, tell your doctor if you have
You may not be able to take mefloquine, or you may require a dosage
adjustment or special monitoring during treatment if you have any of the conditions listed above.
Mefloquine is in the FDA pregnancy category C. This means that it is not known whether it
will be harmful to an unborn baby. Animal studies have shown that it may be dangerous. It is
recommended that a reliable birth control be used during treatment with mefloquine. Do not take this
medication without first talking to your doctor if you are pregnant or could become pregnant during
treatment.
Mefloquine passes into breast milk and may affect a nursing baby. Do not take mefloquine
without first talking to your doctor if you are breast-feeding a baby.
How should I take mefloquine?
Take mefloquine exactly as directed by your doctor. If you do not understand these directions,
ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass, at least 8 ounces (240 mL) of water.
Take mefloquine immediately after a meal.
For children or those who have difficulty swallowing, mefloquine can be crushed and mixed with
water or sugar water. Talk to your healthcare provider if swallowing the tablets is difficult.
If vomiting occurs within 30 minutes of taking a dose of mefloquine, an additional dose should
be taken. If vomiting occurs within 30 to 60 minutes of taking a dose, an additional half-dose should be
taken unless otherwise directed by your doctor.
For malaria prevention, you may need to take mefloquine before you travel, while you are in a
malaria area, and for several weeks after you leave the area. Your healthcare provider will give you
detailed instructions. For the treatment of malaria, directions for taking the medication may be different.
In some cases, serious mental side effects have occurred in people taking mefloquine. Stop
taking mefloquine and seek medical attention immediately if unexplained signs of anxiety, depression,
restlessness, feelings that people are against you, hallucinations (seeing or hearing things that are not
there, for example), psychotic behavior, thoughts of suicide, or confusion occur. If you stop taking
mefloquine, leave the malaria area unless you are able to contact a health care provider or have access
to another medication to protect against malaria. You should be aware that leaving the malaria area
does not protect you from getting malaria. You still need to take a medicine to protect against malaria.
Mefloquine is not 100% effective for the prevention of malaria. Protective clothing, insect
repellents, and bednets are important components of malaria prophylaxis. Seek medical attention for
any illness with fever that occurs after return from a malarious area and inform your doctor that you may
have been exposed to malaria.
Tell your healthcare providers that you are taking mefloquine before taking any new
medications. Also, tell you healthcare providers if you have recently finished taking mefloquine before
taking any new medications.
Store mefloquine at room temperature away from moisture and heat.
What happens if I miss a dose of mefloquine?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose,
skip the missed dose and only take the next regularly scheduled dose.
Do not
take a
double dose of the medication.
Where can I get more information about mefloquine?
Your pharmacist has information about mefloquine written for health professionals that you may read.
What are the possible side effects of mefloquine?
In some cases, serious mental side effects have occurred in people taking mefloquine. Stop
taking mefloquine and seek medical attention immediately if unexplained signs of anxiety, depression,
restlessness, feelings that people are against you, hallucinations (seeing or hearing things that are not
there, for example), psychotic behavior, thoughts of suicide, or confusion occur. However, it is
important to continue to take a medicine for protection from malaria when traveling to a malaria area. A
healthcare provider may need to prescribe a different medication.
Mefloquine may affect your liver and your eyes if you take it for a long time. Ask your
healthcare provider to tell you if you should have your eyes and liver checked while taking mefloquine.
If you experience any of the following serious side effects, seek emergency medical
attention:
Other, less serious side effects may be more likely to occur. Continue to
take mefloquine and talk to your doctor if you experience
-
nausea, vomiting, diarrhea, or loss of appetite;
-
chills or fever;
-
muscle aches or weakness;
-
ringing in the ears;
-
a rash or itching;
-
blurred vision;
-
insomnia or abnormal dreams;
-
headache; or
-
dizziness or drowsiness.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about mefloquine?
In some cases, serious mental side effects have occurred in people taking mefloquine. Stop
taking mefloquine and seek medical attention immediately if unexplained signs of anxiety, depression,
restlessness, feelings that people are against you, hallucinations (seeing or hearing things that are not
there, for example), psychotic behavior, thoughts of suicide, or confusion occur. However, it is
important to continue to take a medicine for protection from malaria when traveling to a malaria area. A
healthcare provider may need to prescribe a different medication.
Use caution when driving or performing other hazardous activities until you know how this
medication affects you. Mefloquine may cause dizziness, restlessness, or confusion during therapy and
for several weeks after treatment has ended.
Mefloquine is not 100% effective for the prevention of malaria. Protective clothing, insect
repellents, and bednets are important components of malaria prophylaxis. Seek medical attention for
any illness with fever that occurs after return from a malarious area and inform your doctor that you may
have been exposed to malaria.
What should I avoid while taking mefloquine?
Use caution when driving or performing other hazardous activities until you know how this
medication affects you. Mefloquine may cause dizziness, restlessness, or confusion during therapy and
for several weeks after therapy is stopped.
Mefloquine is not 100% effective for the prevention of malaria. Protective clothing, insect
repellents, and bednets are important components of malaria prophylaxis. Seek medical attention for
any illness with fever that occurs after return from a malarious area and inform your doctor that you may
have been exposed to malaria.
Immunizations that use live attenuated (weakened) strains of a virus or bacteria should be
completed at least 3 days before the first dose of mefloquine to ensure an adequate effect of the
immunization.
What other drugs will affect mefloquine?
Do not take mefloquine with any of the following medications without first talking to your
doctor:
-
a heart medicine in the class called beta-blockers, such as
propranolol (Inderal), metoprolol (Lopressor), acebutolol (Sectral), betaxolol (Kerlone),
carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard),
pindolol (Visken), timolol (Blocadren), and others;
-
any medicine used to treat seizures;
-
chloroquine (Aralen); or
-
quinidine (Cardioquin, Quinaglute, Quinora, Quinidex) or
quinine (Quinamm).
Taking mefloquine may be dangerous if you are taking any of the
medications listed above.
Immunizations that use live attenuated (weakened) strains of bacteria should be completed at
least 3 days before the first dose of mefloquine to ensure an adequate effect of the immunization.
Drugs other than those listed here may also interact with mefloquine. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals,
and herbal products.
What happens if I have an overdose of mefloquine?