Norepinephrine is similar to adrenaline. It works by constricting (narrowing) the blood
vessels and increasing blood pressure and blood glucose (sugar) levels.
Norepinephrine is used to treat life-threatening low blood pressure (hypotension) that can
occur with certain medical conditions or surgical procedures. This medication is often used
during CPR (cardio-pulmonary resuscitation).
Norepinephrine may also be used for purposes other than those listed in this medication
guide.
What should I discuss with my healthcare provider before taking norepinephrine?
Before receiving norepinephrine, tell your doctor if you are allergic to any drugs, or if you
have:
high blood pressure (hypertension);
overactive thyroid; or
asthma or a sulfite allergy;
If you have any of these conditions, you may not be able to receive
norepinephrine, or you may need dosage adjustments or special tests during treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant during treatment.
It not known whether norepinephrine passes into breast milk or if it could harm a
nursing baby. Do not receive this medication without telling your doctor if you are
breast-feeding a baby.
How should I take norepinephrine?
Norepinephrine is given as an injection through a needle placed into a large vein.
You will receive this injection in a hospital or emergency setting. Norepinephrine is
usually given for as long as needed until your body responds to the medication. Some people
must receive norepinephrine for several days.
To be sure norepinephrine is not causing harmful effects, your blood pressure and
breathing will be checked during the entire time you are receiving this medication.
Tell your caregivers if you have any pain, irritation, cold feeling, or other discomfort of
your skin or veins where the medicine is injected. Norepinephrine can damage the skin or tissues
around the injection site if the medication accidentally leaks out of the vein.
What happens if I miss a dose of norepinephrine?
Since norepinephrine is usually given as needed in a hospital or emergency setting, it is
not likely that you will miss a dose.
Where can I get more information about norepinephrine?
Your pharmacist has information about norepinephrine written for health professionals that you may read.
What are the possible side effects of norepinephrine?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
muscle pain or weakness, numb or cold feeling in your arms and
legs, trouble breathing, nausea with vomiting;
fast, slow, or uneven heart rate;
blue lips or fingernails, mottled skin;
urinating less than usual or not at all;
irritation of the skin or vein where the medicine is injected;
sudden numbness or weakness, especially on one side of the
body; or
sudden headache, confusion, problems with vision, speech,
or balance.
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about norepinephrine?
Before receiving norepinephrine, tell your doctor if you have high blood pressure
(hypertension), overactive thyroid, asthma, or a sulfite allergy.
Tell your caregivers right away about any serious side effects such as muscle pain or
weakness, numb or cold feeling, trouble breathing, urinating less than usual, irritation of the skin
or vein where the medicine is injected, uneven heart rate, sudden numbness or weakness,
especially on one side of the body, or sudden headache, confusion, or problems with vision,
speech, or balance.
Symptoms of a norepinephrine overdose may include slow heart rate, severe
headache, blurred vision, trouble concentrating, increased sensitivity to light, stabbing chest or
back pain, pale skin, sweating, vomiting, or seizure (convulsions).
What should I avoid while taking norepinephrine?
Follow your doctor's instructions about any restrictions in food, beverages, activities, or
other medications after treatment with norepinephrine.
What other drugs will affect norepinephrine?
Before receiving norepinephrine, tell your doctor if you are using any of the following
drugs:
blood pressure medications;
an MAO inhibitor such as isocarboxazid (Marplan),
phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine
(Parnate); or
an antidepressant such as amitriptyline (Elavil, Etrafon),
amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin
(Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or
trimipramine (Surmontil).
If you are using any of these drugs, you may not be able to receive
norepinephrine, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect norepinephrine. Tell your doctor about
all the prescription and over-the-counter medications you use. This includes vitamins, minerals,
herbal products, and drugs prescribed by other doctors. Do not start using a new medication
without telling your doctor.
What happens if I have an overdose of norepinephrine?
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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Content provided by Multum - Last Updated 11/10/2009