What should I avoid while taking acetaminophen, pamabrom, and pyrilamine?
Do not use any other cough, cold, allergy, pain, or sleep medication without first asking your
doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP"), pamabrom, and pyrilamine
are contained in many combination medicines. If you take certain products together you may
accidentally take too much of a certain drug. Read the label of any other medicine you are using to see
if it contains acetaminophen, APAP, pamabrom, or pyrilamine.
Avoid drinking alcohol. It can increase drowsiness caused by pyrilamine, and can increase
the risk of liver damage while you are taking acetaminophen. If you drink more than three alcoholic
beverages per day, do not take acetaminophen, pamabrom, and pyrilamine without your doctor's
advice, and never take more than 2 grams (2000 mg) of acetaminophen per day.
This medication can cause side effects that may impair your thinking or reactions. Be
careful if you drive or do anything that requires you to be awake and alert.
What other drugs will affect acetaminophen, pamabrom, and pyrilamine?
Before using acetaminophen, pamabrom, and pyrilamine, tell your doctor if you regularly
use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain
medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can
add to sleepiness caused by acetaminophen, pamabrom, and pyrilamine.
The following drugs may interact with acetaminophen, pamabrom, and pyrilamine. Tell your
doctor if you are using any of these:
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atropine (Atreza, Sal-Tropine);
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cholestyramine (Questran);
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isoniazid;
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warfarin (Coumadin);
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zidovudine (Retrovir, AZT);
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a bronchodilator;
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diabetes medications you take by mouth;
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gout medications such as probenecid (Benemid);
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medications to treat or prevent nausea, vomiting, or motion
sickness; or
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medicine to treat stomach ulcers, incontinence, or irritable
bowel syndrome.
Acetaminophen can be harmful to the liver, and these effects may be
increased when acetaminophen, pamabrom, and pyrilamine is used together with other medicines that
can harm the liver. Before taking this medication, tell your doctor if you are also using:
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cancer medications
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tuberculosis medications;
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birth control pills or hormone replacement therapy;
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methotrexate (Rheumatrex, Trexall);
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arthritis medications such as auranofin (Ridaura);
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an ACE inhibitor such as benazepril (Lotensin), captopril
(Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), quinapril
(Accupril), and others;
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an antibiotic such as dapsone, erythromycin (E.E.S.,
EryPed, Ery-Tab, Erythrocin), or rifampin (Rifadin, Rifamate);
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an antifungal medication such as fluconazole (Diflucan),
itraconazole (Sporanox), or ketoconazole (Nizoral);
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cholesterol medications such as niacin (Advicor),
atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others;
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HIV/AIDS medications such as
abacavir/lamivudine/zidovudine (Trizivir), lamivudine (Combivir, Epivir), nevirapine
(Viramune), tenofovir (Viread), or zidovudine (Retrovir);
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an NSAID (non-steroidal anti-inflammatory drug) such as
ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren),
etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others; or
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seizure medications such as carbamazepine (Carbatrol,
Tegretol), phenytoin (Dilantin), and others.
This list is not complete and there may be other drugs that can interact with
acetaminophen, pamabrom, and pyrilamine. Tell your doctor about all your prescription and
over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start a new medication without telling your doctor.