Propafenone is in a group of drugs called Class IC anti-arrhythmics. It affects the way your
heart beats.
Propafenone is used in certain situations to prevent serious heart rhythm disorders.
Propafenone may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking propafenone?
You should not use this medication if you are allergic to propafenone, or if you have:
untreated or uncontrolled congestive heart failure;
a heart condition called "sick sinus syndrome" or "AV
block" (unless you have a pacemaker);
slow heartbeats or severely low blood pressure;
an electrolyte imbalance; or
a breathing disorder such as asthma.
If you have any of these other conditions, you may need a dose adjustment
or special tests to safely take propafenone:
congestive heart failure;
liver disease;
kidney disease;
lupus;
arthritis;
myasthenia gravis; or
if you have had a heart attack within the past 2 years.
FDA pregnancy category C. It is not known whether propafenone is
harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan
to become pregnant during treatment.
Propafenone may pass into breast milk and could harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
How should I take propafenone?
You will need to receive your first few doses of propafenone in a hospital setting in case the
medication causes serious side effects. Your heart rate will be constantly monitored using an
electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of
the heart.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or
for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this
medication.
To be sure this medication is helping your condition, your blood may need to be tested on a
regular basis. Do not miss any scheduled appointments.
Store propafenone at room temperature away from moisture, heat, and light.
What happens if I miss a dose of propafenone?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait
until then to take the medicine and skip the missed dose.
Do not
take extra medicine
to make up the missed dose.
Where can I get more information about propafenone?
Your pharmacist has information about propafenone written for health professionals that you may read.
What are the possible side effects of propafenone?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
pale skin, easy bruising or bleeding, unusual weakness;
confusion, unusual thoughts or behavior; or
seizure.
Less serious side effects may include:
dizziness;
unusual or unpleasant taste in your mouth;
nausea, vomiting;
warmth, redness, or tingly feeling under your skin;
constipation;
headache;
tired feeling;
ringing in your ears;
unusual dreams; or
blurred vision.
This is not a complete list of side effects and others may occur. Tell your
doctor about any unusual or bothersome side effect. You may report side effects to FDA at
1-800-FDA-1088.
What is the most important information I should know about propafenone?
You should not use this medication if you are allergic to propafenone, or if you have
untreated or uncontrolled congestive heart failure, a heart condition called "sick sinus syndrome" or
"AV block" (unless you have a pacemaker), slow heartbeats or severely low blood pressure, an
electrolyte imbalance, or a breathing disorder such as asthma.
Before you take propafenone, tell your doctor if you have congestive heart failure, liver or
kidney disease, lupus, arthritis, myasthenia gravis, or if you have had a heart attack within the past 2
years.
You will need to receive your first few doses of propafenone in a hospital setting in case the
medication causes serious side effects. Your heart rate will be constantly monitored using an
electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of
the heart.
Call your doctor at once if you have a serious side effect such as weak pulse, slow
breathing, feeling like you might pass out, feeling short of breath, swelling, rapid weight gain, pale skin,
easy bruising or bleeding, unusual weakness, confusion, unusual thoughts or behavior, or seizure.
What should I avoid while taking propafenone?
Grapefruit and grapefruit juice may increase your blood levels of propafenone which could lead
to unwanted side effects. Discuss the use of grapefruit products with your doctor. Do not increase or
decrease the amount of grapefruit products in your diet without first talking to your doctor.
What other drugs will affect propafenone?
Many drugs can interact with propafenone. Below is just a partial list. Tell your doctor if you
are using:
cimetidine (Tagamet),
digoxin (digitalis, Lanoxin);
ketoconazole (Nizoral);
orlistat (alli, Xenical);
quinidine (Quinaglute, Quinidex, Quin-Release);
rifampin (Rifadin, Rifamate, Rimactane);
a blood thinner such as warfarin (Coumadin);
an antidepressant such as desipramine (Norpramin),
fluoxetine (Prozac), imipramine (Tofranil), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine
(Effexor);
HIV or AIDS medication such as ritonavir (Norvir) or
saquinavir (Invirase);
another heart rhythm medication such as amiodarone
(Cordarone, Pacerone);
medicine to treat psychiatric disorders, such as haloperidol
(Haldol); or
a beta-blocker such as atenolol (Tenormin), labetalol
(Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), sotalol
(Betapace), timolol (Blocadren), and others.
This list is not complete and there may be other drugs that can interact with
propafenone. Tell your doctor about all your prescription and over-the-counter medications, vitamins,
minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication
without telling your doctor.
What happens if I have an overdose of propafenone?
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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Content provided by Multum - Last Updated 11/10/2009