Tricosal

Generic Name: choline salicylate-magnesium salicylate
Other Brand Names: Trilisate, choline salicylate-magnesium salicylate

What is choline magnesium trisalicylate?

Choline magnesium trisalicylate is in a class of drugs called salicylates. It works by reducing substances in the body that cause pain and inflammation.

Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as osteoarthritis, rheumatoid arthritis, other arthritic conditions, and acute painful shoulder.

Choline magnesium trisalicylate may also be used for purposes other than those listed in this medication guide.

Uses Side Effects Precautions Interactions Overdose
What should I discuss with my healthcare provider before taking choline magnesium trisalicylate?

Before taking this medication, tell your doctor if you

  • have an allergy to aspirin or any other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, others), naproxen (Aleve, Naprosyn, Anaprox, others), indomethacin (Indocin), ketoprofen (Orudis KT, Orudis, Oruvail), nabumetone (Relafen), oxaprozin (Daypro), and others;

  • have an ulcer or bleeding in your stomach;

  • drink more than three alcoholic beverages a day;

  • have liver disease;

  • have kidney disease;

  • have gout;

  • have a coagulation (bleeding) disorder;

  • have congestive heart failure;

  • have fluid retention;

  • have heart disease; or

  • have high blood pressure.

You may not be able to take choline magnesium trisalicylate, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Choline magnesium trisalicylate is in the FDA pregnancy category C. This means that it is not known whether choline magnesium trisalicylate will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Choline magnesium trisalicylate passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Do not use choline magnesium trisalicylate to treat a child or teenager who has a fever, flu symptoms, or chicken pox without first talking to a doctor. In children younger than 18 years of age, this medication may increase the risk of Reye"s syndrome, a rare but often fatal condition.

How should I take choline magnesium trisalicylate?

Take choline magnesium trisalicylate exactly as directed by your doctor or follow the instructions that accompany the package if you are using an over-the-counter medicine. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Take choline magnesium trisalicylate with milk, food, or an antacid to lessen stomach upset. Enteric-coated choline magnesium trisalicylate is specially formulated to be gentle on your stomach. Enteric-coated a choline magnesium trisalicylate can be, but does not have to be, taken with milk or food and should not be taken with an antacid.

Do not break, chew, or crush the enteric-coated tablets. These have a special coating to protect your stomach. Swallow them whole.

Do not take choline magnesium trisalicylate more often than every 4 hours, and do not take more than is recommended. If your condition does not improve within 3 to 4 days, seek medical attention.

Be aware of the salicylate (aspirin) content of other prescription and over-the-counter medications to avoid taking too much.

Store choline magnesium trisalicylate at room temperature away from moisture and heat.

What happens if I miss a dose of choline magnesium trisalicylate?

If you are taking choline magnesium trisalicylate regularly—for example, to treat arthritis—take the missed dose up to 2 hours late. If more than 2 hours have passed since the missed dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose.

If you are taking choline magnesium trisalicylate on an as-needed basis and you miss a dose, take it as soon as you remember. Do not take another dose for at least 4 hours.

Where can I get more information about choline magnesium trisalicylate?
Your pharmacist has information about choline magnesium trisalicylate written for health professionals that you may read.
What are the possible side effects of choline magnesium trisalicylate?

Stop taking choline magnesium trisalicylate and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • black, bloody, or tarry stools;

  • nausea, vomiting, or abdominal pain;

  • uncontrolled fever;

  • blood in your urine or vomit;

  • decreased hearing or ringing in the ears;

  • seizures; or

  • dizziness, confusion, or hallucinations.

If you experience any of the following less serious side effects, notify your doctor:

  • heartburn or indigestion,

  • faint ringing in the ears,

  • drowsiness, or

  • headache.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about choline magnesium trisalicylate?

Take choline magnesium trisalicylate with milk, food, or an antacid to lessen stomach upset. Enteric-coated choline magnesium trisalicylate is specially formulated to be gentle on your stomach. Enteric-coated a choline magnesium trisalicylate can be, but does not have to be, taken with milk or food and should not be taken with an antacid.

Do not break, chew, or crush the enteric-coated tablets. These have a special coating to protect your stomach. Swallow them whole.

Avoid alcohol or use it in moderation while taking choline magnesium trisalicylate. If you drink more than three alcoholic beverages a day, the risk of stomach bleeding may increase.

What should I avoid while taking choline magnesium trisalicylate?

Avoid taking other over-the-counter or prescription medications containing aspirin or another salicylate and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Nuprin, others), naproxen (Aleve, Naprosyn, Anaprox, others), indomethacin (Indocin), ketoprofen (Orudis KT, Orudis, Oruvail), nabumetone (Relafen), oxaprozin (Daypro), and others during treatment with choline magnesium trisalicylate. Taking too much of these medicines can be dangerous.

Avoid alcohol or use it in moderation while taking choline magnesium trisalicylate. If you drink more than three alcoholic beverages a day, the risk of stomach bleeding may increase.

Tell your doctor and dentist that you are taking choline magnesium trisalicylate, especially if you need to undergo a surgical procedure. Choline magnesium trisalicylate may prolong bleeding.

What other drugs will affect choline magnesium trisalicylate?

Do not take choline magnesium trisalicylate without first talking to your doctor if you are taking any of the following medicines:

  • an anticoagulant such as warfarin (Coumadin), heparin, enoxaparin (Lovenox), dalteparin (Fragmin), danaparoid (Orgaran), ardeparin (Normiflo), or tinzaparin (Innohep);

  • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Voltaren, Cataflam), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), or tolmetin (Tolectin); or

  • another salicylate such as aspirin (Acuprin, Ecotrin, Ascriptin, Bayer, others), magnesium salicylate (Magan, Doan’s, Bayer Select Backache Pain Formula, Mobidin, Arthropan), or salsalate (Disalcid).

You may not be able to take choline magnesium trisalicylate, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

If you have diabetes, moderate to large doses of choline magnesium trisalicylate may produce false urine glucose test results.

Many drugs, including those not listed here, can interact with choline magnesium trisalicylate, resulting in side effects and/or decreased effectiveness of the medications. Do not take any other prescription or over-the-counter medicines or herbal products without first talking to your doctor during treatment with choline magnesium trisalicylate.

What happens if I have an overdose of choline magnesium trisalicylate?

Seek emergency medical attention.

Symptoms of a choline magnesium trisalicylate overdose include ringing in the ears, headache, nausea, vomiting, dizziness, confusion, hallucinations, coma, seizures, rapid breathing, and fever.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Content provided by Multum - Last Updated 2/11/2008