Before using laronidase, tell your doctor if you have other medical conditions, if you take other prescription or over-the-counter medicines including vitamins, minerals, and herbal products, or if you have ever had an allergic reaction to laronidase, another medication, foods, dyes, or preservatives in the past. You may not be able to use laronidase, or you may require a dosage adjustment or special monitoring during treatment.
Laronidase is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use laronidase without first talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether laronidase passes into breast milk. Do not use laronidase without first talking to your doctor if you are breast-feeding a baby.
Use laronidase exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Laronidase is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.
Your doctor may prescribe other medications to be taken before receiving the laronidase injection. These may help prevent or reduce the severity of an allergic or infusion reaction. Take these medications as directed by your healthcare provider.
Your doctor may want you to have blood tests or other medical evaluations during treatment with laronidase to monitor progress and side effects.
Your healthcare provider will store laronidase as instructed by the manufacturer. If you are storing laronidase at home, your healthcare provider will give you instructions regarding how to store the medication.
Contact your doctor if you miss a dose of laronidase.
Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; low blood pressure; and dizziness; have occurred upon injection of laronidase in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of laronidase.
Other less serious side effects such as flushing and redness, pain or swelling at the injection site may be more likely to occur following injection of laronidase. Talk to your doctor about any side effects that you experience.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; low blood pressure; and dizziness; have occurred upon injection of laronidase in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of laronidase.
There are no restrictions on food, beverages, or activity during treatment with laronidase.
Laronidase is not known to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including vitamins, minerals, and herbal products, during treatment with laronidase.
Contact your doctor, a hospital emergency room, or a poison control center if an overdose is suspected.
Although symptoms of an laronidase overdose are not known, an overdose is unlikely to threaten life.