primidone

Generic Name: primidone

What is primidone?

Primidone is used to control seizures. The exact way that it works is unknown. However, it is believed that primidone alters the chemical impulses in the brain that cause seizures.

Although not approved by the FDA for this purpose, primidone has also been used to control tremor (shaking).

Primidone may also be used for purposes other than those listed in this medication guide.

Uses Side Effects Precautions Interactions Overdose
What should I discuss with my healthcare provider before taking primidone?

Do not take primidone if you have porphyria.

Discuss with your doctor any other medical conditions that you have and any medicines that you take, including over-the-counter preparations.

It is not known whether primidone will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Primidone passes into breast milk and may affect a nursing infant. Do not take primidone without first talking to your doctor if you are breast-feeding a baby.

How should I take primidone?

Take primidone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose of primidone with a full glass of water.

Primidone can be taken with food if it upsets your stomach.

Shake the liquid form of primidone well before measuring a dose. To ensure that you get a correct dose, measure the suspension with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Carry or wear a medical identification tag to let others know that you are taking this medicine in the case of an emergency.

Do not stop taking your medication, even if you feel better. It is important to continue taking primidone to prevent your seizures from recurring.

Store primidone at room temperature away from moisture and heat.

What happens if I miss a dose of primidone?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

Where can I get more information about primidone?
Your pharmacist has information about primidone written for health professionals that you may read.
What are the possible side effects of primidone?

If you experience any of the following serious side effects, stop taking primidone and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • a rash;

  • worsening of seizures; or

  • a fever.

Other, less serious side effects may be more likely to occur. Continue to take primidone and talk to your doctor if you experience

  • dizziness, poor coordination, or drowsiness;

  • blurred or double vision;

  • irregular back-and-forth movements of the eyes; or

  • nausea and vomiting.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about primidone?

Do not stop taking your medication even if you feel better. It is important to continue taking primidone to prevent your seizures from recurring.

Carry or wear a medical identification tag to let others know that you are taking this medicine in the case of an emergency.

Use caution when driving, operating machinery, or performing other hazardous activities. Primidone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

What should I avoid while taking primidone?

Do not drink alcohol while taking this medication. Alcohol can cause deep sedation or sleepiness. It may also increase the risk of seizures.

Use caution when driving, operating machinery, or performing other hazardous activities. Primidone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

What other drugs will affect primidone?

Primidone interacts with most other antiepileptic medicines.

Acetazolamide (Diamox), carbamazepine (Tegretol), ethosuximide (Zarontin), and methsuximide (Celontin) may all decrease the effects of primidone, and larger primidone doses may be necessary.

Phenytoin (Dilantin), ethotoin (Peganone), mephenytoin (Mesantoin), and isoniazid (Nydrazid) may increase blood levels of primidone. An adjustment of your primidone dosage may be necessary.

Carbamazepine (Tegretol) blood levels may be higher during therapy with primidone. An adjustment of the carbamazepine dosage may be necessary.

Drugs other than those listed here may also interact with primidone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

What happens if I have an overdose of primidone?

Seek emergency medical treatment.

Symptoms of a primidone overdose include dizziness; drowsiness; an uncoordinated feeling; nausea; vomiting; blurred vision; and irregular, rapid eye movements.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Content provided by Multum - Last Updated 2/11/2008