Do not use mitomycin without first talking to your doctor if you have
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kidney disease;
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poorly functioning bone marrow; or
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a bleeding or blood clotting disorder
The use of mitomycin may be dangerous if you have any of the conditions listed above.
Mitomycin may be harmful to an unborn baby.
It is not know whether mitomycin passes into breast milk. Breast-feeding should be avoided during treatment with mitomycin.
Mitomycin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
Your doctor will determine the correct amount and frequency of treatment with mitomycin depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.
Tell your doctor or nurse right away if you notice redness, pain or swelling at the place of injection or anywhere else on your skin.
Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with mitomycin to monitor progress and side effects.
Your healthcare provider will store mitomycin as directed by the manufacturer. If you are storing mitomycin at home, follow the directions provided by your healthcare provider.
Contact your doctor if you miss a dose of mitomycin.
If you experience any of the following serious side effects from mitomycin, contact your doctor immediately:
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an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
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kidney damage (little or no urine production, blood in the urine, lower back or side pain, difficulty urinating, or swelling of the ankles or feet);
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decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
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redness, pain or swelling at the place of injection or elsewhere on the skin;
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severe nausea, vomiting, diarrhea, or loss of appetite; or
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shortness of breath or difficulty breathing.
Other, less serious side effects may be more likely to occur. Continue taking mitomycin and talk to your doctor if you experience:
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mild to moderate nausea, vomiting, or loss of appetite;
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headache;
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blurred vision;
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drowsiness or dizziness;
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weakness; or
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confusion.
Other side effects have also been reported. Discuss with your doctor any side effect that occurs during treatment with mitomycin.
Mitomycin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of mitomycin including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); kidney damage (little or no urine production, blood in the urine, lower back or side pain, difficulty urinating, or swelling of the ankles or feet); lung and heart problems; and others. Talk to your doctor about the possible side effects from treatment with mitomycin.
Tell your doctor or nurse right away if you notice redness, pain or swelling at the place of injection or anywhere else on your skin.
Mitomycin can lower the activity of the immune system making you more susceptible to infection. Avoid contact with people who have colds, the flu, or other contagious illnesses. In addition, do not receive vaccines that contain a live strain of the virus (e.g., live oral polio vaccine) and avoid contact with individuals who have recently been vaccinated with a live virus.
Do not receive "live” vaccines during treatment with mitomycin. Administration of a live vaccine may be dangerous during treatment with mitomycin.
Other drugs may also interact with mitomycin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with mitomycin.
If, for any reason an overdose of mitomycin is suspected, seek emergency medical attention or contact your healthcare provider immediately.
Symptoms of a mitomycin overdose tend to be similar to side effects caused by the medication, although often more severe.