Sporanox Information - Drugs and Treatments

What is itraconazole?

Itraconazole is an antifungal medication.

Itraconazole is used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.

Itraconazole may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking itraconazole?

Do not take this medication if you are allergic to itraconazole or similar medications such as fluconazole (Diflucan) or ketoconazole (Nizoral), if you have ever had congestive heart failure, or if you are pregnant or planning to become pregnant during treatment.

The following drugs should not be taken together with itraconazole:

cisapride (Propulsid);
dofetilide (Tikosyn);
nisoldipine (Sular);
pimozide (Orap);
quinidine (Quinaglute, Quinidex, Quin-Release);
lovastatin (Altocor, Altoprev, Mevacor) or simvastatin (Zocor);
midazolam (Versed) or triazolam (Halcion);
ergot medicines such as dihydroedrgotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), ergotamine (Ergomar, Cafergot, Ercaf, Migergot), or methylergonovine (Methergine); or
(these drugs are no longer available in the U.S.) astemizole (Hismanal), or levomethadyl Orlaam).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take itraconazole:

heart disease, a heart rhythm disorder, circulation problems, or a history of stroke;
chronic obstructive pulmonary disease (COPD) or other breathing disorder;
kidney disease;
liver disease;
cystic fibrosis; or
a personal or family history of "Long QT syndrome."

FDA pregnancy category C. It is not known whether itraconazole is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Itraconazole passes into breast milk and can harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take itraconazole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

The itraconazole

tablet

should be taken after a full meal.

Take itraconazole

oral solution (liquid)

on an empty stomach, at least 1 hour before or 2 hours after a meal. Swish the liquid in your mouth for several seconds before swallowing it.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Itraconazole capsules should not be used in place of itraconazole oral solution (liquid) if that is what your doctor has prescribed. Make sure you have received the correct type of this medication at the pharmacy and ask the pharmacist if you have any questions.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Call your doctor if your symptoms do not improve.

To be sure this medication is not causing harmful effects, your liver function may need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.

Store itraconazole at room temperature away from moisture, heat, and light.

What happens if I miss a dose of itraconazole?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time.

Do not

take extra medicine to make up the missed dose.

Where can I get more information about itraconazole?

Your pharmacist has information about itraconazole written for health professionals that you may read.

What is the most important information I should know about itraconazole?

You should not take itraconazole together with cisapride (Propulsid), dihydroergotamine (D.H.E. 45, Migranal), dofetilide (Tikosyn), ergonovine (Ergotrate), ergotamine (Ergomar), lovastatin (Altocor, Altoprev, Mevacor), methylergonovine (Methergine), midazolam (Versed), nisoldipine (Sular), pimozide (Orap), quinidine (Quinaglute, Quinidex, Quin-Release), simvastatin (Zocor), or triazolam (Halcion).

Other drugs that should not be taken together with itraconazole include astemizole (Hismanal), or levomethadyl Orlaam) (these drugs are no longer available in the U.S.).

There are many other medicines that can interact with itraconazole.

Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Before taking itraconazole, tell your doctor if you have heart disease, a history of stroke, a heart rhythm disorder, kidney or liver disease, a breathing disorder, cystic fibrosis, or a history of "Long QT syndrome."

What should I avoid while taking itraconazole?

Avoid taking antacids or stomach acid reducers (Tagamet, Pepcid, Axid, Zantac, and others) within 1 hour before or 2 hours after you take itraconazole. These medications can make it harder for your body to absorb itraconazole.

What other drugs will affect itraconazole?

Many drugs can interact with itraconazole. Below is just a partial list. Tell your doctor if you are using:

a blood thinner such as warfarin (Coumadin);
cancer medications;
cholesterol medications such as atorvastatin (Lipitor);
cyclosporine (Gengraf, Sandimmune, Neoral);
diabetes medication you take by mouth;
digoxin (digitalis, Lanoxin);
disopyramide (Norpace);
fentanyl (Actiq, Duragesic);
isoniazid (for treating tuberculosis);
rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater, Rifamate), or rifapentine (Priftin);
sirolimus (Rapamune) or tacrolimus (Prograf);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), telithromycin (Ketek), or troleandomycin (Tao).
an antifungal medication such as clotrimazole (Mycelex Troche), ketoconazole (Nizoral), or voriconazole (Vfend);
an antidepressant such as nefazodone, paroxetine (Paxil), or sertraline (Zoloft);
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
heart or blood pressure medications such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase, Fortovase), or ritonavir (Norvir);
a sedative such as alprazolam (Xanax), diazepam (Valium); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and there are many other medicines that can interact with itraconazole.



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What is itraconazole?

itraconazole