What is chlorpromazine (oral)?
Chlorpromazine is an anti-psychotic medication in a group of drugs called phenothiazines
(FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.
Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression,
and severe behavioral problems in children. It is also used to treat nausea and vomiting, anxiety before
surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.
Chlorpromazine may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking chlorpromazine (oral)?
Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine
may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
Do not use chlorpromazine if you have brain damage, bone marrow depression, or are also
using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to
chlorpromazine or other phenothiazines such as fluphenazine (Permitil), perphenazine (Trilafon),
prochlorperazine (Compazine, Compro), promethazine (Adgan, Pentazine, Phenergan), thioridazine
(Mellaril), or trifluoperazine (Stelazine).
If you have certain conditions, you may need a dose adjustment or special tests to safely use
this medication. Before you take chlorpromazine, tell your doctor if you have:
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liver or kidney disease;
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heart disease or high blood pressure;
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severe asthma, emphysema, or other breathing problem;
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glaucoma;
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past or present breast cancer;
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low levels of calcium in your blood (hypocalcemia);
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adrenal gland tumor (pheochromocytoma);
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an enlarged prostate or urination problems;
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a history of seizures;
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Parkinson's disease; or
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if you have ever had a serious side effect while using
chlorpromazine or any other phenothiazine.
Tell your doctor if you will be exposed to extreme heat or cold, or to
insecticide poisons while you are taking chlorpromazine.
It is not known whether chlorpromazine will harm an unborn baby. Chlorpromazine may
cause side effects in a newborn if the mother takes the medication during pregnancy. Do not take this
medication without first talking to your doctor if you are pregnant. Tell your doctor if you become
pregnant while taking chlorpromazine.
Chlorpromazine can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
Talk with your doctor before giving this medication to a child who has been ill with a fever or flu
symptoms.
Older adults may be more likely to have side effects from this medication.
How should I take chlorpromazine (oral)?
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or
for longer than recommended. Follow the directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results from this medication.
This medication can cause you to have unusual results with certain medical tests. Tell any
doctor who treats you that you are using chlorpromazine.
If you need to have any type of x-ray scan or MRI of your spinal cord, tell the doctor
ahead of time that you are using chlorpromazine. You may need to stop using the medicine for a short
time.
Do not stop using chlorpromazine suddenly after long-term use, or you could have
unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky. Talk to your
doctor about how to avoid withdrawal symptoms when you stop using chlorpromazine.
Store chlorpromazine at room temperature away from moisture and heat.
What happens if I miss a dose of chlorpromazine (oral)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait
until then to take the medicine and skip the missed dose.
Do not
take extra medicine
to make up the missed dose.
Where can I get more information about chlorpromazine (oral)?
Your pharmacist has information about chlorpromazine (oral) written for health professionals that you may read.
What are the possible side effects of chlorpromazine (oral)?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking chlorpromazine and call your doctor at once if you have a serious side effect
such as:
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twitching or uncontrollable movements of your eyes, lips, tongue,
face, arms, or legs;
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tremor (uncontrolled shaking), drooling, trouble
swallowing, problems with balance or walking;
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feeling restless, jittery, or agitated;
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feeling like you might pass out;
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seizure (black-out or convulsions);
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nausea and stomach pain, skin rash, and jaundice
(yellowing of the skin or eyes);
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pale skin, easy bruising or bleeding, fever, sore throat, flu
symptoms;
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high fever, stiff muscles, confusion, sweating, fast or
uneven heartbeats, rapid breathing;
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unusual thoughts or behavior;
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decreased night vision, tunnel vision, watery eyes, increased
sensitivity to light;
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urinating less than usual or not at all;
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joint pain or swelling with fever, swollen glands, muscle
aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
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slow heart rate, weak pulse, fainting, slow breathing
(breathing may stop).
Less serious side effects may include:
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dizziness, drowsiness, anxiety, sleep problems (insomnia);
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breast swelling or discharge;
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changes in menstrual periods;
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weight gain, swelling in your hands or feet;
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dry mouth or stuffy nose, blurred vision;
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constipation; or
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impotence, trouble having an orgasm.
This is not a complete list of side effects and others may occur. Tell your
doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about chlorpromazine (oral)?
Stop using this medication and call your doctor at once if you have twitching or
uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of
dangerous side effects.
Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine
may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
Do not use chlorpromazine if you have brain damage, bone marrow depression, or are also
using large amounts of alcohol or medicines that make you sleepy. Do not use if you are allergic to
chlorpromazine or other phenothiazines.
Before you take chlorpromazine, tell your doctor if you have liver or kidney disease, heart
disease or high blood pressure, glaucoma, severe breathing problems, past or present breast cancer,
low levels of calcium in your blood, adrenal gland tumor, enlarged prostate or urination problems, a
history of seizures, Parkinson's disease, or if you have ever had a serious side effect while using
chlorpromazine or similar medicines.
Before taking chlorpromazine,
tell your doctor about all other medications you
use.
What should I avoid while taking chlorpromazine (oral)?
Chlorpromazine can cause side effects that may impair your thinking or reactions. Be
careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast
from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a
fall.
Avoid drinking alcohol. It can increase some of the side effects of chlorpromazine.
Avoid exposure to sunlight or tanning beds. Chlorpromazine can make your skin more
sensitive to sunlight, and a sunburn may result. Wear sunscreen (SPF 15 or higher) and protective
clothing if you must be outdoors.
What other drugs will affect chlorpromazine (oral)?
Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers,
and medicine for seizures, depression or anxiety can interact with chlorpromazine and cause medical
problems or increase side effects. Tell your doctor if you regularly use any of these medicines, or any
other anti-psychotic medications.
Also tell your doctor if you are using any of these:
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atropine (Atreza, Sal-Tropine);
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lithium (Eskalith, Lithobid);
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phenytoin (Dilantin);
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an antibiotic;
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birth control pills or hormone replacement estrogens;
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blood pressure medication;
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a blood thinner such as warfarin (Coumadin);
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certain asthma medications or bronchodilators;
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incontinence medications;
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insulin or diabetes medications you take by mouth;
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medication for nausea, vomiting, or motion sickness;
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medications to treat or prevent malaria;
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medications used for general anesthesia;
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medicines used to prevent organ transplant rejection;
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numbing medicine such as lidocaine or Novocain;
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a stimulant or ADHD medication;
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ulcer or irritable bowel medications; or
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medicines to treat Parkinson's disease, restless leg
syndrome, or pituitary gland tumor (prolactinoma).
This list is not complete and there are many other medicines
that can interact with chlorpromazine.
Tell your doctor about all your prescription and
over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other
doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the
medicines you use and show this list to any doctor or other healthcare provider who treats you.
What happens if I have an overdose of chlorpromazine (oral)?
