Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too
much salt, which can cause fluid retention.
Metolazone treats fluid retention (edema) in people with congestive heart failure, or a kidney
disorder such as nephrotic syndrome. This medication is also used to treat high blood pressure
(hypertension).
Metolazone may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking metolazone?
Do not use this medication if you are allergic to metolazone, or if you have:
severe liver disease; or
if you are unable to urinate.
If you have certain conditions, you may need a dose adjustment or special
tests to safely take this medication. Before using metolazone, tell your doctor if you have:
kidney disease;
liver disease;
gout;
diabetes; or
an allergy to sulfa drugs.
FDA pregnancy category B. This medication is not expected to be
harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during
treatment.
Metolazone can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
How should I take metolazone?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger
amounts, or take it for longer than recommended by your doctor. Follow the directions on your
prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this
medication.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a
regular basis. Do not miss any scheduled appointments.
Your blood and urine may both be tested if you have been vomiting or are dehydrated.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking
metolazone. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medication even if you feel fine.
High blood pressure often has no symptoms.
Store the tablets at room temperature away from heat, light, and moisture.
What happens if I miss a dose of metolazone?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at the next regularly scheduled time.
Do not
take
extra medicine to make up the missed dose.
Where can I get more information about metolazone?
Your pharmacist has information about metolazone written for health professionals that you may read.
What are the possible side effects of metolazone?
Get emergency medical help if you have any of these
signs of an allergic
reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have a serious side effect
such as:
dry mouth, thirst, nausea, vomiting;
feeling weak, drowsy, restless, or light-headed;
fast or uneven heartbeat;
muscle pain or weakness;
chest pain;
urinating less than usual or not at all; or
numbness or tingly feeling.
Less serious side effects may include:
dizziness;
headache;
joint pain;
a red, blistering, peeling skin rash; or
blurred vision.
This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to FDA at
1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about metolazone?
Do not use this medication if you are unable to urinate, or if you have severe liver disease.
Before using this medication, tell your doctor if you have liver disease, kidney disease, asthma,
allergies, gout, diabetes, or an allergy to sulfa drugs.
Avoid drinking alcohol, which can increase some of the side effects of metolazone.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your
doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking
too much liquid can be as unsafe as not drinking enough.
There are many other medicines that can interact with metolazone. Tell your doctor about all
the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal
products, and drugs prescribed by other doctors. Do not start using a new medication without telling
your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other
healthcare provider who treats you.
If you are being treated for high blood pressure, keep using this medication even if you feel fine.
High blood pressure often has no symptoms.
What should I avoid while taking metolazone?
Avoid drinking alcohol, which can increase some of the side effects of metolazone.
Avoid using other medicines that make you light-headed (narcotic pain medication, muscle
relaxers, and medicine for seizures). They can add to the side effects of metolazone. Tell your doctor if
you regularly use any of these medicines, or any other blood pressure medications.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your
doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking
too much liquid can be as unsafe as not drinking enough.
What other drugs will affect metolazone?
Before taking this medication, tell your doctor if you are using any of the following drugs:
lithium (Lithobid, Eskalith);
digoxin (Lanoxin);
methenamine (Hiprex, Mandelamine, Urex);
steroids (prednisone and others);
insulin or diabetic medicine you take by mouth;
a blood thinner such as warfarin (Coumadin);
furosemide (Lasix) or other blood pressure medications;
salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid,
Salflex, Tricosal, and others; or
NSAIDs (non-steroidal anti-inflammatory drugs) such as
aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve,
Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.
This list is not complete and there may be other drugs that can interact with
metolazone. Tell your doctor about all the prescription and over-the-counter medications you use.
This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start
using a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
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a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or
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given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
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interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse
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Content provided by Multum - Last Updated 11/10/2009