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Anxiety Community

This patient support community is for discussions relating to generalized anxiety, anxiety and eating, anxiety and sleeping, mood swings, and phobias.
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Clomipramine (Anafranil) and Lithium for Insomnia

by gj77, Apr 04, 2007 12:00AM
Hi,
I was wondering if anyone is on this combination for insomnia and OCD. Is it safe to take Lithium for long periods? I was told to take Lithium 500 mg as Clomipramine (Anafranil) 100 mg alone didn't help the OCD.  However Clomipramine (Anafranil) helped in the insomnia.
Member Comments (3)

by RCA7591, Apr 04, 2007 12:00AM
Anafranil is a Tricyclic antidepressant, and Lithium is a "mood stabilizer" primarily used to treat bipolar disorder with mania.

Anafranil is indicated for both depression and obsessive-compulsive disorder. It is a potent drug alone, and is fairly safe if you don't have a history of cardiac problems or blood clotting.

Lithium has no known benefit in OCD. As stated, it's a mood stabilizer. Prolonged Lithium use can lead to accumulation and toxic side effects, therefore, periodic blood tests are required to establish the plasma level. Lithium has a narrow therapeutic window, and if exceeded in even small amounts, can lead to toxic levels. I would question the use of Lithium for treatment of OCD (certainly, better drugs are avaliable).

There are some other Tricyclic choices as well. If Anafranil is not working, Tofranil could be tried in its place. The SSRI's (Zoloft, Paxil, Prozac) are also indicated for OCD.

As for the safety of Anafranil and Lithium combined, they are safe. I would not use the Lithium unless there were some underlying reason to justify its use (bipolar disorder with mania).

-Ryan

by gj77, Apr 05, 2007 12:00AM
To: Ryan
Thanks for the reply. I was told to take Lithium cos I get anxious and nervous when I take cloroprimine. Your comments? Have u recovered completely from anxiety/ depression? Hope so..

by RCA7591, Apr 05, 2007 12:00AM
My viewpoint: Find another doctor, preferably a Psychiatrist who understands these types of drugs.

Lithium has no known benefit in anxiety states, nor is it of value for OCD. I would question the doc as to why he prescribed Lithium, as it is a "serious" drug, and carries with it, potential serious risks.

Lithium is used to regulate the "up's and downs" of bipolar disorder (the up's being "mania"), a mood stabilizer. Anxiety is not "mania".

Since you are already taking a tricyclic, a trial period of Sinequan (Doxepin), may prove useful, as Sinequan is also indicated for anxiety. Unlike Tofranil and Anafranil (which are stimulating), Sinequan has a mild sedative effect. Sinequan, when useful, is a better choice than the Benzodiazepines.

If there is no response from the Sinequan, a Benzodiazepine such as Librium or Klonopin would be a good choice.

I'd ditch the Lithium (with your doctor's blessing). He's using it "off-label" (very off label).

-Ryan
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