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Breast Cancer (Expert Forum)
Arimidex or Herceptin Chemo?Radiotherapy,Brachytherapy,Mammosite or Hi-art?
Questions posted in the Breast Cancer Forum are answered by medical professionals from The Cleveland Clinic. Topics include Breast Biopsy, Chemotherapy, Hormone Therapy, Lumps, Lumpectomy, Lymph node dissection, Lymphedema, Mammograms, Mastectomy, Radiation Therapy, Reconstruction, Self Breast Exam, and Surgery.
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Arimidex or Herceptin Chemo?Radiotherapy,Brachytherapy,Mammosite or Hi-art?
by JerryAthensGreece, Oct 24, 2005 12:00AM
Patient:Maria,very active ex.athlete,excellent condition.
Birth 08/1936
Other Disases:serotonine problems,panic crisis etc,degenerated athritis.
TOTAL HYSTERECTOM 1985
Abortion 1965
Total thyroidectomy 2004 (no cancer found) treated since 2004 with T4 (PROBLEMS WITH THIS PILL)
Period cycle 1947(11 years old)
One son caesarian 1964
Regular mammographys every 1-2 years after 1985
Last mammography Janyary 2005 no tumor found
Date of tumor suspition: September 2005, mammography
Operation on end of september 2005
T1 NO MO (stage 1)
Final Diagnosis :
Left breast Quatrandectomy(low exterior quarter of the left breast) plus partial lumpectomy
Type: Mixte type carcinoma, invasing Lobular classic and Ductal, 1.7cm (1,7X1,5) ,compact, not specified type,GradeII(6),
The lobular infiltrating carcinoma with linear cell structure.
Resection margins free
Excised Lymph Nodes 8, free of cancer (with the SLN negative)
ER-ica = Hi-Score 240
PR-ica =Hi-Score 60
c-erb-b2=positive(+)
20-25% off the cells with high positive expression on the antibody CB11against Her2/Neu(Cerb-b2)(score3+)(NO FISH!)
Negative for antibody DO7 against Proteine p53
Negative against Cathepsine D
35-40% of the cells positive cytoplastic expression to the antibody against the proteine pS2
5-10% of the cells with positive nuclear expression to the antibody against the cell-groath factor Ki67(M1B1)
75-80% of the cells with strongly positive expression against the ER-ica
25-30% of the cells with midle positive expression against pPR-ica
What should she do?Please help me,i am her son, Jerry
Birth 08/1936
Other Disases:serotonine problems,panic crisis etc,degenerated athritis.
TOTAL HYSTERECTOM 1985
Abortion 1965
Total thyroidectomy 2004 (no cancer found) treated since 2004 with T4 (PROBLEMS WITH THIS PILL)
Period cycle 1947(11 years old)
One son caesarian 1964
Regular mammographys every 1-2 years after 1985
Last mammography Janyary 2005 no tumor found
Date of tumor suspition: September 2005, mammography
Operation on end of september 2005
T1 NO MO (stage 1)
Final Diagnosis :
Left breast Quatrandectomy(low exterior quarter of the left breast) plus partial lumpectomy
Type: Mixte type carcinoma, invasing Lobular classic and Ductal, 1.7cm (1,7X1,5) ,compact, not specified type,GradeII(6),
The lobular infiltrating carcinoma with linear cell structure.
Resection margins free
Excised Lymph Nodes 8, free of cancer (with the SLN negative)
ER-ica = Hi-Score 240
PR-ica =Hi-Score 60
c-erb-b2=positive(+)
20-25% off the cells with high positive expression on the antibody CB11against Her2/Neu(Cerb-b2)(score3+)(NO FISH!)
Negative for antibody DO7 against Proteine p53
Negative against Cathepsine D
35-40% of the cells positive cytoplastic expression to the antibody against the proteine pS2
5-10% of the cells with positive nuclear expression to the antibody against the cell-groath factor Ki67(M1B1)
75-80% of the cells with strongly positive expression against the ER-ica
25-30% of the cells with midle positive expression against pPR-ica
What should she do?Please help me,i am her son, Jerry
Doctor's Answer
by CCF-RN,MSN-rf, Oct 25, 2005 12:00AM
Dear JerryAthensGreece: The best advice we can give over the internet is to have your mother meet and speak with a medical oncologist (preferably one who specializes in breast cancer). There are many factors that play into the decision of how to treat a person and it simply is not safe medicine to make specific recommendations via the internet. For most patients with invasive breast cancer, some additional treatment called "adjuvant therapy" will be recommended. Such treatments may include radiation therapy, hormonal (actually antihormonal) therapy, chemotherapy or newer biologic treatments. A discussion an oncologist would be helpful to review the risks and benefits of the various treatment options for her individual situation.
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Already in contact with the surgeon-oncologist specialist in breast cancer. (I think he did an excellent job). His opinion is classic 6-7 week of radiation therapy and then Arimidex plus vitamin D3 (colecalciferon) + calcium. One other Oncologist suggest definitely Herceptin in combination with chemo (paclixatel or carboplatine) and a second one, first a revue of the pathology (FISH method to be sure of HER2 3+) then Chemo, after hormonotherapy (arimidex) and then radiotherapy (no immunotherapie because is for metastatic breast cancer as he told me)
I am a little confused with the different opinions and hade read hundred of internet info pages. I am trying to do the best thing, with the fewer mistakes. My father died from lung cancer in 1998.Now is a new battle for us. My mother is 69 but looks and act like 55.I don’t want in any raison to deteriorate here quality of life considering her actual age.