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Breast Cancer (Expert Forum)
Can't understand my pathology report... Please help!
Questions posted in the Breast Cancer Forum are answered by medical professionals from The Cleveland Clinic. Topics include Breast Biopsy, Chemotherapy, Hormone Therapy, Lumps, Lumpectomy, Lymph node dissection, Lymphedema, Mammograms, Mastectomy, Radiation Therapy, Reconstruction, Self Breast Exam, and Surgery.
Can't understand my pathology report... Please help!
by KDC, Mar 28, 2002 12:00AM
Dear Doctor,
Could you please give me some estimation on my survival chance based on my pathology report attached? I just had my breast cancer operation and am now very confused and scared... What kind of chemotherapy do I need?
I deeply appreciate you kind advice and recommendation.
Best,
KDC
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Large specimen over 10 Slides
Pathological diagnosis:
Breast, right, modified radical mastectomy
Invasive ductal carcinoma without lymph nodal metastasis
Gross:
The specimen consists of a piece of breast tissue with pectoris muscle. The breast measures 25*15*2.5cm, and it is covered by an elliptical skin, measuring 12*6 cm. A gray white tumor, 6*1.5*1.5 cm, is found. Enlargement of auxiliary lymph nodes, up to 1*0.8*0.6 cm, is noted. The pectoris muscle shows no remarkable change. Representative parts are embedded in eight blocks.
Microscopy:
1. Tumor type: Invasive ductal carcinoma, NOS
2. Histological grade: Grade II
3. Nuclear grade: Grade II
4. Tumor necrosis: Present
5. Tumor calcification: Absent
6. Vascular invasion: Absent
7. Perineural invasion: Absent
8. Stromal reaction: inflammatory
9. Surgical margins: All margins are free of tumor
10. Ductal carcinoma in situ: Absent
11. Non-neoplastic breast: Unremarkable
12. Lymph nodes: Axillary-(0/9) --- Reactive hyperplasia
13. Extranodal extension: Absent
14. Estrogen receptor: Negative
15. Progestrone receptor: Negative
16. P53: Negative
17. HER2/neu: Moderately positive intensity in 30% of tumor cells (+/+++)
DNA histogram diagnosis:
Aneuploid: 56.6%, DN
Could you please give me some estimation on my survival chance based on my pathology report attached? I just had my breast cancer operation and am now very confused and scared... What kind of chemotherapy do I need?
I deeply appreciate you kind advice and recommendation.
Best,
KDC
-----------------
Large specimen over 10 Slides
Pathological diagnosis:
Breast, right, modified radical mastectomy
Invasive ductal carcinoma without lymph nodal metastasis
Gross:
The specimen consists of a piece of breast tissue with pectoris muscle. The breast measures 25*15*2.5cm, and it is covered by an elliptical skin, measuring 12*6 cm. A gray white tumor, 6*1.5*1.5 cm, is found. Enlargement of auxiliary lymph nodes, up to 1*0.8*0.6 cm, is noted. The pectoris muscle shows no remarkable change. Representative parts are embedded in eight blocks.
Microscopy:
1. Tumor type: Invasive ductal carcinoma, NOS
2. Histological grade: Grade II
3. Nuclear grade: Grade II
4. Tumor necrosis: Present
5. Tumor calcification: Absent
6. Vascular invasion: Absent
7. Perineural invasion: Absent
8. Stromal reaction: inflammatory
9. Surgical margins: All margins are free of tumor
10. Ductal carcinoma in situ: Absent
11. Non-neoplastic breast: Unremarkable
12. Lymph nodes: Axillary-(0/9) --- Reactive hyperplasia
13. Extranodal extension: Absent
14. Estrogen receptor: Negative
15. Progestrone receptor: Negative
16. P53: Negative
17. HER2/neu: Moderately positive intensity in 30% of tumor cells (+/+++)
DNA histogram diagnosis:
Aneuploid: 56.6%, DN
Doctor's Answer
by CCF-RN,MSN-rf, Mar 28, 2002 12:00AM
Dear KDC: If I am reading the dimensions of the tumor correctly, 6 x 1.5 x 1.5 with negative lymph nodes, then this would be a T3 size tumor and make your disease stage llB. The 5 year survival statistic for stage llB breast cancer is 70-75%. In other words, it is likely that you will do very well. In this case chemotherapy would be recommended. Depending on your health and other factors the drugs MAY include AC (adriamycin, cytoxan)and/or taxol. There are other regimens as well and your oncologist would make the recommendation specific to your situation.
Here it is. Please kindly advise.
----
Aneuploid: 56.6%, DNA Index: 1.87, SPF: 10.7%