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Fertility / Infertility (Expert Forum)

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Estradiol and Clomid

Questions in the Fertility/Infertility forum are answered by doctors affiliated with USF Health. Topics covered include fertility or infertility issues, egg quality, fertility drugs and side effects, fertility tests, genetic testing, in-vitro fertilization (IVF), ovulation, relationship issues, risk factors, sperm count/quality, and surgery.

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MedHelp Member's Question

Estradiol and Clomid

by jellybean1756, Nov 14, 2007 12:00AM

Can you please tell me if estradiol has effect on OPKs? I know clomid does. Also, can you tell me if my Ovulation will be delayed...guess I am not sure what exactly the estradiol will do? I am on 3rd month of clomid, took 50mg first two months and now 100mg and now dr put me on estradiol (days 10-14) started the estradiol yesterday.
Thank you!

Doctor's Answer

by Forum-M.D.-SP, Nov 19, 2007 12:00AM

It is hard to predict. The higher levels of estrogen may promote the midcycle LH surge, which is what urine OPKs look for. If this happens, the surge might come a couple of days earlier. This is called positive feedback. On the other hand, the higher estrogen levels my inhibit LH (this is called negative feedback) delaying the surge. You will need to test for ovulation to find out.

Member Comments (2)

by NCsmom, Nov 15, 2007 12:00AM

Here's what my RE told me:
Your body tends to naturally select or favor one follicle a month and hold the others back while it matures. The estradiol supresses this mechanism, allowing multiple follicles to mature, and making your chlomid or other drugs a better shot at producing multiple eggs.

by sabath, Sep 10, 2008 02:38PM

A related discussion, Will low dy3 FSH&E2 remain low on dy10 (per natural/normal cycle) was started.

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