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Extremely High levels ALT ( SGPT )
by yvonne, Aug 02, 2000 12:00AM
I am a very healthy 47 yrs old female. Seven days ago I had a laparoscopic surgery for gallbladder removal under general anesthesia. Prior to surgery I had only
one gallbladder attack, there was no inflammation nor emergency to remove it and I did not take any medication. Prior to gallbladder removal my ALK Phos was 64, Glucose serum random 4.8, biliribin total 10, creatine 71, S got 19.
For first seven days after operation I had no pain, every fast
recovery with no symptoms and I was taking 2 tablets of 30mg of acetaminophen with codein and caffein every 6 hours.( Total 35 tablets in 7 days)
My diet: no fat, liquid mainly fruit diet.
On the seventh day I had accute abdominal pain and blood test indicated: ALT (SGPT) 425, ALK PHOS 209, Glucose 5.8, creatine
74, bilirium 15. X-ray and utrasound were normal.
The pain went away & I start walking, I discontinued tylanol 3
(acetaminophen with codein) and day later went for blood test:
My results were better, but still not normal: ALT (SGPT) 253,
ALK PHOS 164, AST 53, B-HCG Screen negative, bilirium 14.
one gallbladder attack, there was no inflammation nor emergency to remove it and I did not take any medication. Prior to gallbladder removal my ALK Phos was 64, Glucose serum random 4.8, biliribin total 10, creatine 71, S got 19.
For first seven days after operation I had no pain, every fast
recovery with no symptoms and I was taking 2 tablets of 30mg of acetaminophen with codein and caffein every 6 hours.( Total 35 tablets in 7 days)
My diet: no fat, liquid mainly fruit diet.
On the seventh day I had accute abdominal pain and blood test indicated: ALT (SGPT) 425, ALK PHOS 209, Glucose 5.8, creatine
74, bilirium 15. X-ray and utrasound were normal.
The pain went away & I start walking, I discontinued tylanol 3
(acetaminophen with codein) and day later went for blood test:
My results were better, but still not normal: ALT (SGPT) 253,
ALK PHOS 164, AST 53, B-HCG Screen negative, bilirium 14.
Post Comment
MY BROTHER WAS DONATED HIS LIVER TO MY MOTHER WHO COULDN'T SURVIVE THE OPERATION. POST OPP HE WAS OK BUT NOW HIS S.G.P.T. AND S.G.O.T. LEVELS HAVE SKY ROCKETED. I WANT TO KNOW MORE ABOUT IT AND HOW CAN I HELP HIM.
High liver enzymes can be associated to bile duct injury from the surgery. But in some people the cause is not clear and the enzymes go back down to normal in a few days.
Are elevated liver enzymes and bilirubin levels significant after laparoscopic cholecystectomy in the absence of bile duct injury?
OBJECTIVE: Increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin levels were noted incidentally after a laparoscopic cholecystectomy. The percentage in which such elevation occurs and its clinical significance in the absence of bile duct injury were investigated. SUMMARY BACKGROUND DATA: Bile duct injury is the most feared complication of laparoscopic cholecystectomy. Some laboratory tests may be indicative of this complication, such as increases in liver enzyme (AST, ALT, and alkaline phosphatase [ALP]) and bilirubin. These parameters have not been investigated in patients who had laparoscopic cholecystectomy and in whom no damage to the bile duct was noted. METHODS: Sixty-seven patients with normal results of preoperative liver function test were entered into the study. Blood was collected 24 hours after laparoscopic cholecystectomy, and AST, ALT, ALP, and bilirubin levels were measured. RESULTS: A mean 1.8-fold increase in AST occurred in 73% of patients; 82% showed a 2.2-fold increase in ALT. A statistically nonsignificant increase was noted in 53% of patients (ALP remained within normal limits), and in 14% of patients bilirubin levels were increased (they were primarily of the unconjugated type). CONCLUSIONS: In many patients a significant increase in AST and ALT levels occurred after laparoscopic cholecystectomy, but they returned to normal values within 72 hours. The cause of this is unclear, and these elevations appear to have no clinical significance.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1243152
It's impossible to tell what's happening based on only two results. It could be as simple as the elevation being caused by any medication or supplements he may be taking. Or it can also be related to complications from the surgery (depending on how long ago he had the surgery).
One of the most common complications is injury to the bile duct during the surgery which can cause bile leakage.....and that would cause the sgpt and sgot to be high. But that would probably happen in the first few weeks after surgery.....not a year later (you didn't mention how long ago he had the surgery).
I'm sure whatever the problem is, his doctor will be monitoring his condition.
Best of luck to both of you.
"liver donor complications occur in as many as 30 percent of patients, and that up to 15 percent of them have bile leakage. Most problems are minor, even correcting themselves, but some require a second surgery. "
http://www.pittsburghlive.com/x/pittsburghtrib/news/cityregion/s_563373.html