Hepatitis

therapeutic vaccine decreases fibrosis - early trials

Forum: The Hepatitis Forum
Topic: Hepatitis C

From	To	Post
mikeymike2 3/25/2004	.	What follows is an extract from a press relese by Innogenetics The full release can be found at http://www.innogenetics.be/site/newspressrecent.asp?id=126 Seems like some good news to me - but don't get too excited as these things don't always work out Innogenetics today announced the 3-year histology data of its ongoing phase 2a study in hepatitis C (HCV) patients, which started in early 2001. After 4 courses of HCV E1-based therapeutic vaccine injections given over a 3-year period in 23 patients, liver fibrosis on average showed significant improvement compared to baseline. The key finding that has now emerged is a regression (improvement) of liver fibrosis averaging minus 0.43 points (95% confidence interval [-0.82, -0.05]) on the Ishak fibrosis scale. This result constitutes a significant decrease (p = 0.044) from baseline. No less than 87% (20/23) of the patients either improved (10/23) or remained stable (10/23) in their Ishak liver fibrosis score. This group of patients (mean age at entry 53 years, HCV genotype 1, with active liver disease) were, for the most part, non-responders to previous interferon-based therapy. Such patients would be expected to show a marked progression in liver fibrosis of about + 0.60 to about + 0.99 points on average...

tonyz 3/25/2004 C3	Great New	I have followed the vaccine injections, but have not heard much about it lately. This is good news. I hope the vaccine works out and is avalible soon. I would like to be in the clinical trials and recieving the vaccine injections. mikeymike2 thanks for the heads up. TonyZ
LvdByGod 3/25/2004 C4	.	that's great news! i wish it was available for those of us who need to stop progression now. it sounds like this first of trials will be completed in 2005. i wonder what they must do after that to get it on the market? anyone know?
Galen 3/25/2004 C5	.	Sorry to bust in on this thread but I wanted to tell everyone that I just got my 6 month all clear!!!!!!!!! For those who don't know me, I WAS genotype 1B, had it for over 30 years, VL around 1,000,000, mild damage, and asymptomatic. I did 48 weeks of PegIntron and Riba, along with Neupogen and Procrit from week 9 to the end. I've been feeling great for the past couple of months and now even greater!!!!!
martee 3/25/2004 C7	Galen	Congratulations sweetie ! What a great feeling that must be ! Someday I hope to be able to say the same. I wish you all the best, and please continue to post. I'm always interested in what you have to say. Stay well :)
tallblonde 3/25/2004 C8	Galen	Wonderful news, Galen! Best wishes for continued good health and much happiness! Susan
honey15637 3/25/2004 C9	Galen	That is wonderful and I am so happy for you! Just to hear the sweet words of svr at 6 months must make you feel great! That is so encouraging also for all of us 1's on clearing this mean old virus right out!!
BD146 3/25/2004 C10	Galen	Thank you for sharing your wonderful news. I am genotype 1b. You have demonstrated that there is hope. Continued recovery is my wish for you. God bless.... Edgar
caruu 3/25/2004 C11	Galen	This is wonderful news! I am so happy for you. You deserve the great news and renewed health! caruu
jonihs 3/25/2004 C12	Galen/ Mikey	Galen: YYYEEEAAAAHHH!!!! Mickey, Thank you, that kind of info gives us old cirrhosis sufferers hope also !!!!!! JONI
Indiana 3/25/2004 C13	Galen	DING-**** THE DRAGONS DEAD!!! 95% OR BETTER NOW BABY!!! THATS THE KINDA NEWS WE LIKE TO HEAR!! ANOTHER ONE BITES THE DUST!!! I am Sooooo happy for you. You studied, and learned, and fought your way through.....to THIS end. Ain't it GREAT??? What a ride eh? You're gonna make it now sweetie. Keep in touch and holler at me at the 1 year mark. Then tell me when our dinner date is.......bring your sisters. hahahahahaha
willing 3/25/2004 C14	Galen,MickeyMike	galen: great news - congratulations on becoming an official SVR! I wish you all the best and many thanks for everything you've contributed to this forum. mickeymike: thanks for the interesting link. Looks like taking the drug amounts to taking injections of E1, one of the virus' two envelope proteins. I wonder what's known about sides at this stage? Taking something that boosts specific immunity to HCV would seem to have lighter overall impact on the body than general-purpose immune stimulators like ifn/riba.
raheem 3/25/2004 C15	Galen	Wonderful news, real happy for you. I'm a 1b guy with 5 shots left and I hope to be following in your footsteps!
ambush 3/25/2004 C16	Galen	Oh, Galen, that's just the best news! I'm so happy for you. It's good to hear you're feeling great, too! ambush :)
Minttwist 3/25/2004 C17	Galen/Indiana	Galan....this is great news! Feel like a new women, hum. I'm sure you've gone back to work....business must be booming since you have more energy now, and are able to get out there and advertise a little more, hum. But tell me this Indiana and Galan......is alcohol out of the question forever for you guys? I'm doing okay, don't have any aches or pains; I just feel a little stiffness in my liver area. Doc wants me to take an xray which isn't scheduled until 4/19. 3 Months post I was still clear, but time will only tell. Hi, MAJ Neni. Val.
debbiedo 3/25/2004 C18	Galen	:) I'm so pleased to hear your results. I have appreciated all your support that you have given me since i first posted here last summer. As you might recall, I am also a 1 b ..........Deb
harley dude 3/25/2004 C20	Galen	Great news and good luck with the rest of your "LONG LIFE"- you deserve it- you helped out alot of people tremendously on this forum when they were in real need of advice and a good friend.Can you really believe it's over- wasn't that a hell of a journey. Well at least we can say one thing for sure- we are certainly "Experts" on HCV now. See Ya Around -- Harley Dude
psychdoc 3/25/2004 C21	Galen	That's awesome news! I am so glad you posted. I was wondering how you were doing. I can't seem to get my strength back. I slept for three days already this week and seem to need between 10 and 15 hours of sleep a day. My doctor said I should be over all tx symptoms by now (4 months post tx) so I am looking for a new doctor. Congratulations! Barb
Is_this_real? 3/25/2004 C23	Galen...	Congratulations girl. You have done it. That ole virus never had a chance. I am happy for you sooooo much, and you give us all hope. By the way, I also have some news. As you remember, I am a 1a with an initial very high viral load. I started my Pegasys combo treatment on 1/16/04. Last week, I went in to my doctor for 8 week tests on 3/15/04. After 8 weeks of the drugs, I too am undetectable. I still have 38 shots left, but this should be a breeze now. Recent studies I have read suggest that if a geno 1 treats for 32 to 36 weeks post clearance, their SVR percentage shoudl be 80 - 90%. So, my chances are much improved now!
twotells 3/25/2004 C24	Mikey § Galen § Everyone	Mikey: Thanks for the encouraging information. It's great to see the research moving forward on this terrible virus. Galen: I'm very happy for you. Since I'm also a 1b, the success of your tx is a big encouragement. I know you lost your special kitty recently. That is a sadness I also share since we lost our cat, Keetz. She was our first family cat and we'll miss her. Pets have a special way of helping us when things get tough, don't they. My little eskie dog was there with me when I was in severe pain for months. I keep telling her she's a blessing from God and I mean it. Wasn't going to log on tonight, but I'm glad I did. God Bless, Dave
Indiana 3/25/2004 C25	Mintwist / ITR	Minttwist.....it seems that every time we try to talk about alcohol and hcv, Whatever the reason, it ends up in a fight. So if you really want my thoughts on this, send me an e-mail at Indianamann@aol.com I will respond. I really don't want to ruin this splendid thread. Itr.....There is a lot of current data that says that you now have an "excellent" chance of killing The Dragon. You and I have looked at this for you for a LONG time. I am Sooooo happy that this is working so well for you now. It won't be easy.....but it WILL be worth it. I will be here ...and there... for you. You CAN do this! Best of luck as you go through the gauntlet. We are always here for you........
majneni 3/25/2004 C26	Galen § Minttwist	You go, Galen. Terrific news. We really ought to get a bigger party going for some of us dragonslayers this year. Any badgers in FL? Val, nice to catch your note. I hope you feel better soon, and that life throws fewer spit-balls at you. I'm feeling pretty good now, 2 months after tx. My skin has recovered (exc. for seasonal trouble; Elidel rules); my hair is still thin, and it seems to be a dust-magnet. Blood counts are improving slower than we thought, so I'm using up my leftover Neupogen with the Friday Night brigade. I'm also having some joint-stuff; want to follow up on my low + RA factor. There's an RA study going on here, I'll see if I qualify. My brain is working, except for the memory; and I have good energy until I suddenly hit empty. My appetite is sooooo good. I finished Undetectable on Jan.23, after my 48 weeks. (1b/stage 1/grade 2, high VL to start.) I'm still negotiating for the 3-month PCR... This whole tx business is so mental, and waiting - at every stage - is... well... you know. I've been having computer problems, but I usually still read a couple of times a week. Greetings, folks. I hope we keep it nice here. Majneni
dh bill 3/25/2004 C27	Galen	Congrats! You have helped me and so many others here and as a 1b hope to follow in your footsteps. dh bill
newb 3/26/2004 C28	Galen, I-T-R	Galen- WHOOOOPPPPIEEEE!! That's the best news I've heard all week! Another 1-B bites the dust! Is-this-real, Really happy to hear that you've cleared at 8 weeks. Keep up the good work! Best to all you hep warriors out there. newb
AK - Hepper 3/26/2004 C29	galen	That's really excellent news, looks like you kicked that ol' dragon's butt for good, really gives the rest of us 1b-ers hope!!!!!!
lackalustre 3/26/2004 C30	galen	hey way to go!!! all your hard work paid off!!!! i think we finished around the same time and im also clear 6 mon. post tx. what great news!!! to be able to tell people you are in remission or cured even!!(?) hope you continue to thrive immensely.
LvdByGod 3/26/2004 C31	Galen	congratulations Galen, i'm so happy for you!!! what a relief!!!
lyric 3/26/2004 C32	Galen	Thanks for sharing your wonderful news!!! I have a big smile!! :)
madbyron 3/26/2004 C33	Galen	Congratulations on your excellent news. I'm very pleased for you. Will you be serving your customers champagne at the salon today?
madbyron 3/26/2004 C36	Majneni	Glad to hear from you and that your recovery is going reasonably well. Bummer about the Orange not making it to the final four this year...
fubarcat 3/26/2004 C37	Galen	Happy Day for you! As a 1B, you have certainly given me encouragement to finish my next 38 weeks. I go for my 12 weeks PCR on April 9 and am anxiously awaiting getting the results already. But hearing that you made it through to the other side makes the wait bearable. I am so happy for you! Thanks for all your contributions to this Board. Celebrate Life!
ts2010 3/26/2004 C38	Galen/ITR	Congratulations to the both of you!! It is a happy day indeed. It gives hope to the rest of us on or contemplating tx.
lize 3/26/2004 C39	GALEN	I AM SO THRILLED FOR YOU!!!!!!!!!!!!!!!! OH HAPPY DAYS R HERE AGAIN!!!!!!!!!!! U CAN NOW KICK BACK AND JUST ENJOY... BE WELL ALWAYS, LIZE :O)
cuteus 3/26/2004 C40	galen/all post tx svrs	I noticed the WAS 1b thingy. I guess once 1b NOT ALWAYS 1b! felicitazioni! felitations! felicidades! etc etc
mikesimon 3/26/2004 C41	Galen	Congratulations to you. You deserve this. Stay well. Mike
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Hepatitis

therapeutic vaccine decreases fibrosis - early trials

Forum: The Hepatitis Forum Topic: Hepatitis C

Forum: The Hepatitis Forum
Topic: Hepatitis C