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Mental Health  (Expert Forum)
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Panic disorder with CONSTANT anxiety? PLEASE HELP!!
Answered by
Roger Gould, M.D. - Mental Health, Wellness
Questions posted in the Mental Health forum are being answered by Dr. Roger L. Gould, author of the Mastering Stress and Depression program and affiliated with the UCLA. Department of Psychiatry. Topics covered include anger, attention deficit disorder (ADD), bipolar disorder, dementia, electroconvulsive therapy (ECT), learning disabilities, memory, obsessive compulsive disorder (OCD), panic, personality disorders, phobias, post-traumatic stress disorder (PTSD), schizophrenia, stress, transitions, and work problems.

Panic disorder with CONSTANT anxiety? PLEASE HELP!!

by imcrazy2, Oct 19, 2006 12:00AM
I have panic disorder with agoraphobia.  I have been prescribed Paxil, Prozac, & Ativan at different times over the past 8 years.  I was in cognitive-behavior therapy for over a year, which helped my understanding, but of course, doesn't change my biology, or physical sensations associated with anxiety. Today, my doctor decided I should try effexor since the latest attempt (PaxilCR) doesn't seem to be working properly. (OK, fine, but....)

My question is this; Everything I read about panic disorder, or panic attacks, anxiety, etc says that a panic attack comes on, peaks, and wanes.  If that were true for me, I think I would be able to handle it.  My panic attacks last for days, or even weeks, coming in powerful waves, but when the waves recede, I am left with this CONSTANT heightened PHYSICAL (I can't stress enough, I am a very laid back person with few worries, my issues are ALL PHYSICAL/ ADRENALINE-type sensations) anxiety characterized by derealization, jitteriness, dizzy/lightheadedness, excess nervous energy, and such.  Nothing I read about describes this....the closest thing is generalized anxiety, but this is always described as constant worry/stress (mental).

I have been examined by an endocrinologist, who said that although I match exactly the profile for hyperthyroidism, and have elevated blood metanepherine levels, he couldn't definitively diagnose a thyroid or adrenal condition (my TSH and T4 always come back either normal or borderline), and thus couldn't treat me.

I am desperate to know if there is some sort of hormonal (cortisol levels came back ok), or chemical (aside from the seratonin, obviously) BIOLOGICAL root that is TREATABLE.  I realize that the agoraphobia means that I am still bound to be pre-disposed to working myself into a panic attack when faced with triggers, but those things I can understand, so I can deal with them.  PLEASE HELP ME!!!!!

by Roger Gould, M.D., Oct 20, 2006 12:00AM
Ask your doctor about a strong dose of beta blockers when the attacks first start.  That should prevent the secondary exhaustion you describe after the attack.  There are probably people doing research on this who might be able to follow more hormone levels more accurately as they happen, so keep digging for those kind of research projects that focus on cortisol levels.
Member Comments (19)

by scaredycat1, Oct 19, 2006 12:00AM
did the other meds help you, how come you went off them.   there is definitely something out there that will work for you.

by imcrazy2, Oct 19, 2006 12:00AM
I started with Paxil, that worked well, but was EXTREMELY tired, so after about 3 or 4 years switched to Prozac, which also worked for about 3 years.  About 3 weeks after I delivered my 3rd baby, I had SEVERE and bizarre symptoms, felt like the prozac was NOT working at all, in addition to some insane OCD symptoms that I had NEVER had before---best described as "intrusive thoughts".  I was not diagnosed, but am fairly convinced that if I didn't have postpartum psychosis, I was close (had my tubes ties afterward, it was THAT bad).

The doc decided to transition me back to paxil, citing "Prozac Poopout" which evidently just means that the meds just stop working for no apparent reason.  Instead of totally weaning, however, it seemed that a combo of prozac 20/day, & paxil 20/day was working.  So I was fine with that for about 9 months.  Then, my doc (Psychiatrist) was unavailable for an appointment, and I saw her colleague.  Well, that doc FLIPPED out about me being on both, and wanted me to stop the paxil & go back on the prozac, even though I explained that I would rather be narcoleptic on Paxil, than panic ridden on Prozac.  She wouldn't listen, so I went to my GP who wanted to try me on Paxil CR since the only bad side effect I was having from the Paxil was sleepiness, and the CR is supposed to have milder side effects.  whew....short story long, here I am still on CR, sleeping 16 hours + a day,(not an easy thing to accomplish with two toddlers!) and still having anxiety, so today, my GP said she'd call in Effexor. Haven't picked it up yet.  The Ativan I have taken sporadically when things get really bad, but I try hard not to take it--have only had to twice this year--both times in anticipation of medical procedures (I'm a very anxious patient).  I should probablyjust suck it up and take it, but I'm afraid of addiction

by scaredycat1, Oct 19, 2006 12:00AM
I am just about ready for the xanax however am also avoiding it hoping the meds will start kicking in.  but I know they give them to you because it takes time for the meds to kick in and keep you calm in the meantime.  my heart is pounding like crazy and I am trying to function somewhat at work but sick and nervous and can't concentrate.  however I know most people do take this while they are waiting for the meds to kick in just not sure how long to wait and just keep telling myself one more day and I will feel better but when I don't I panic worse which is probably why they prescribe the xanax, I have okay moments though just keep going up and down.  just want to level... ugh... I know how you feel so frustrating. Good luck with those babies, they are what keep you going though it doesn't seem that way now.

by imcrazy2, Oct 19, 2006 12:00AM
hey scaredy, I just responded to your post.....I need to practice what I preach!  LOL

TAKE THE XANAX!!

If you are anxious, TAKE IT.  That's what it's there for.  I know I don't follow my own advice, but I also create panic attacks for myself by taking meds, since I'm afraid of having a reaction....LOL....do you ever feel like a complete nut?  I sure do!

by lifegoezon, Oct 20, 2006 12:00AM
take the xanax! you are a lot stronger than me....i'm waiting for the prozac to kick in and taking ativan as needed. i dont even care about addiction at this point...well i do but i just hate feeling like i cant breathe all the time. my anxietycomes out in choking episodes...its just great. i just want to feel good again...good luck everyone. have a wonderful friday.

by scaredycat1, Oct 20, 2006 12:00AM
how long have you been on the prozac, I know I saw my councilor yesterday and she said the same take the xanax, I just don't want to need it and wonder how long it is going to take for the lexapro to kick in.

by bfjones420, Oct 20, 2006 12:00AM
To: imcrazy2
Do you ever feel relaxed??  Or are you always up tight and tense.  If you are always up tight and tense I would say that the Prozac may be causing some of these symptoms.  SSRIs can be very stimulating or they can be just the opposite and it is not the same for every person.  The SSRI that I remember trying in the past and don't remember making me feel on the edge was Zoloft, but like I said, it is not the same for everyone. I am currently coming off of Paxil because of this stimulating effect.  I can't remember the last time I was able to actually relax.  I can sit and watch tv.....  but my body is not still rockin.  I think I may have Bipolar II and the Paxil may be just stimulating my hypomania so it may not be the same for you but thought it was worth knowing.

by imcrazy2, Oct 20, 2006 12:00AM
this is a tough question.....I do have weeks where I feel pretty normal, but the weeks that I don't are awful.  I am not a high strung person at all, I am very laid back, and those that know me are surprised to find out that I have anxiety, because I don't have a type A personality at all.  I switched to Prozac from Paxil because I was looking forward to the more stimulating effect, since I was practically narcoleptic on Paxil.  If you are switching off of Paxil, I am curious what they are trying on you, because Paxil is known to be one of the LEAST stimulating to the autonomic nervous system--did the Zoloft not work for you?

by NURSELPN, Oct 23, 2006 12:00AM
To: imcrazy2
Quote:

I have been examined by an endocrinologist, who said that although I match exactly the profile for hyperthyroidism, and have elevated blood metanepherine levels, he couldn't definitively diagnose a thyroid or adrenal condition (my TSH and T4 always come back either normal or borderline), and thus couldn't treat me.





imcrazy2,



Did the endo, that you seen, do any thyroid antibodies on you? The antibody tests are for auto-immune thyroid disease...

It is possible to have antibodies to both hashimotos disease causing low thyroid & graves causing high thyroid. Your symptoms can wax & wane (come & go) with this disorder.

Depending on when she checked your lab your TSH & results could be technically normal or boderline & you could still have this disease. You may need to see another Endo who will throughly investigate this for you. I'm surprised your endo has not checked your thyroid antibodies TSI (for graves disease) & TPO (for hashimotos disease).



by imcrazy2, Oct 24, 2006 12:00AM
To: nurselpn
THANK YOU!  I will check that out...my doc (GP) just ordered an iodine uptake test, so we'll see, but I'll  definitely ask about those other tests--noone ever mentioned those!!!

by scaredycat1, Oct 24, 2006 12:00AM
okay so I am just checking in with everyone, hope you are all feeling better I am nuts right now as my husband had knee surgery