I don't know if you will get this as your post is older. I too have extremely elevated B6, do not take vitamins or any supplements that have B6, avoid all foods that have it and it still is going up. My neurologist has sent me to two dietitians who agree it is not coming from my diet but he insists it has to be. It is clear from all the posts here that he is not unusual. Did you ever find anything that helped it come down?

Have you found any relief?

This website has some more information about high b6 levels:
https://www.easy-immune-health.com/vitamin-b6-toxicity.html

2020 - leg/foot numbness, swollen leg, restless at night, poor sleep, one foot felt colder than other.  Doctors thought aggravated old injury, so had to epidurals in L5/4.  No fix.  Symptoms got worse, weight gain then during the million of tests (MRI of brain neck and spine, xrays of spine, EMG). 9 month medical journey and nurse detected irregular heart beat, so on hear condition journey.  Just got lab work done (done last!!!) and have high levels of B6.  So ridiculous this wasn’t tested sooner.  However, I am not taking supplements so reviewing diet.  Things I eat are deemed “healthy” but high levels of B6 (sooo confusing!).  So my diet which I consume normal
Amounts caused this uptick.  The neuro insists to reduce fortified foods (which I don’t eat).  But I can’t deny food is somehow related.  Jan 2021, I eliminated/watched diet closely, increased exercise, water intake and took Turmeric (inflammation constant) and Symptoms improved.  I still have leg/foot numbness and muscle cramps/twitches.  The nuero said she’s seeing lots of patients in my age range with toxic levels of B6.  Still, not leaving this alone as my level was upside (still is) due to this! I thought I was dying.  My chiropractor suggested adrenal gland failure and will take the test to see the outcome.  I did have an unusual amount of stress due.  Seeing chiropractor DID improve symptoms but it was temporary, like a reprieve!   So, I am wondering now if this is parasite or leaky gut issues.  Who knows!  Also, I am awaiting results for the heart palpitations, etc... this has been crazy journey and B6 should never be added to foods.  So dangerous!  I will update soon...awaiting Vit D/B12 results

For those who have much higher than normal B6, you should be checked for Hypophosphatasia (as was said in an earlier past). The cause of Hypophosphatasia is genetic. Look at this website to learn more http://omim.org/entry/146300. That web page states that Teriparatide (an osteoporosis drug) has been used to successfully treat P5P (B6) elevations caused by Hypophosphatasia. Good luck.

Have your friend find another doctor who will help her.
One thing I found interesting when I spoke to a doctor years ago. My female doctor stated to me about how she was trained in medical school if you have a man and a woman with the same issues or symptoms she needed to keep searching for the problem with the male. Now for the female if she can  not figure out what the problem info then the woman's issues are physciatric/mental! Now in order to understand how the medical schools adopted this sextis or discriminated way of thinking we must go back in time and understand who developed this field of study (medicine). It was a male dominate field with male mentality whom really did not understand women. Funny that they (doctors) did not know women even had orgasums and women were treated for these so called fits. They actually thought it was some medical disorder women had actually do belive they needed to be treated for this disorder. Unfortunately not all of doctors stupidity had changed through the years, for those who still treat and training new doctors with these discrimitive, sextis ways of thinking does nothing to help women!
So if anyone is being told it is all in your head and you know your body and what you are experiencing is not normal get a second or unbiased opinion.
Warmest Regards Everyone!

Mike and others,
You all should see a neurologist for these symptoms as they deal with things like tingling numb sensations. They should also help you decide what your options are to help. Maybe pain medication or some other medication. Depending what they find will depend on what they can or will do for you as each person is different with different issues.
Best wishes to all.
Debra An

HI have your symptoms gotten better? Did you ever find out if it was something else beside the b6?

I stumbled upon this thread and am happy to find anyone who can sympathize with me and possibly help me.I have spent the last several years seeing numerous doctor's who haven't been able to figure out what's going on.My newest labs show very high b6.They thought it was a lab error but after 3 tests it isn't. I take no vitamins or prescriptions,not even Tylenol.I have low D,MTHFR double mutation,gluten and soy intolerance.I'm in constant pain.I used to workout daily and now can't even go up the stairs without joing pain.If I do try to work out I get severe muscle spasms afterwards for days.I can't even play with my kids.I have drained my savings account and spent thousands of dollars on doctors and tests.I just can't do it anymore.Any suggestions would be greatly appreciated.  

Hi Chiasma,

I have hashimoto's and hypo, MTHR mutations, and high B5 and B6 too. I am trying to figure out what can be done as well.

NDBMom

I came across this forum by looking up pyrroles disease (aka pyroluria), b6 and zinc deficiencies. I don't know if any of you have heard of pyrroles disease, it seems as though it has only recently been brought attention.

"Pyroluria (Pyrrole disorder) is characterized by an elevated urine kryptopyrrole, which results in a dramatic deficiency of zinc and Vitamin B6. It is a blood disorder, which is genetically transmitted. Because of an abnormality in the synthesis of hemoglobin, a chemical imbalance occurs in the blood. Diagnosis can be made by urine laboratory testing. Treatment consists of Vitamin B6 and zinc."

Testing for pyroluria requires a non-standard urine test that only few labs can do at the moment, however, it seems as though some of you have unusual b6 and zinc levels. Pyroluria has also been associated with MTHFR gene.
http://www.drlam.com/blog/pyroluria-and-adrenal-fatigue-syndrome/5273/
http://mthfr.net/mthfr-mutation-consider-these-laboratory-tests/2012/01/02/

I hope this helps someone.

Thanks all for your effort and time to share.

Could this condition (High B6 and sometimes low Vit D) be as a result of some infection ?

Maggie, I am desperate to find out why my B6 levels are high. I don't take B vitamins, no multi, it has been high for YEARS. I have terrible RLS, I have peripheral neuropathy, I have horrible insomnia. It's awful. My thyroid and adrenals are shot. Can you tell me what your husband was diagnosed with?

How are your symptoms now?

My husband has been dizzy/imbalanced for weeks. He has high B6 levels, never takes supplements but does eat 1 or 2 meals of cereal each day. I'm sure those are fortifies with B6. We also eat chicken, spinach, cantaloupe (lots of bread and veggies too) so he is getting it from diet, but it's hard to believe this diet would cause too much. His primary care doctor referred him to an ENT specialist because inside the ears show pressure/inflammation and the week of steroids didn't fix it. He does not have pain or numbness in extremities. He does have some insomnia, trouble focusing, and very "tipsy" feeling. He sees the ENT tomorrow. I wonder if they will refer him to a neurologist or endocrinologist?

This website may be helpful re neuropathy and other problems associated with MTHFR gene mutation.

Neuropsychiatric & Neurological Conditions: MTHFR mutations have been linked to neuropsychiatric conditions due to the indirect effects of MTHFR activity on the production of serotonin, dopamine and norepinephrine, as well as the potentially toxic effect of hyperhomocysteinemia. Schizophrenia-like syndromes, bipolar disorder, Parkinson’s disease, Alzheimer’s disease and vascular dementia have all been associated with one or more mutations of the MTHFR gene (Lewis, X.  Molecular Psychiatry. 2006;11, 352–360).

Insomnia, irritability, forgetfulness, endogenous depression, organic psychosis, peripheral neuropathy, myelopathy and restless leg syndrome are all also mentioned in the literature as potentially being influenced by this enzyme deficiency. The MTHFR C677T homozygous genotype has also been associated with an increased risk for migraine with aura in most ethnic groups except for Caucasian populations (Schurks M., et al. Headache. 2010; 50(4):588-99).
In a recent metanalysis, there was a relationship between the C677T mutation and increased susceptibility for depression (Lewis, X.  Molecular Psychiatry. 2006;11, 352–360).Neuropsychiatric & Neurological Conditions: MTHFR mutations have been linked to neuropsychiatric conditions due to the indirect effects of MTHFR activity on the production of serotonin, dopamine and norepinephrine, as well as the potentially toxic effect of hyperhomocysteinemia. Schizophrenia-like syndromes, bipolar disorder, Parkinson’s disease, Alzheimer’s disease and vascular dementia have all been associated with one or more mutations of the MTHFR gene (Lewis, X.  Molecular Psychiatry. 2006;11, 352–360).

Insomnia, irritability, forgetfulness, endogenous depression, organic psychosis, peripheral neuropathy, myelopathy and restless leg syndrome are all also mentioned in the literature as potentially being influenced by this enzyme deficiency. The MTHFR C677T homozygous genotype has also been associated with an increased risk for migraine with aura in most ethnic groups except for Caucasian populations (Schurks M., et al. Headache. 2010; 50(4):588-99).
In a recent metanalysis, there was a relationship between the C677T mutation and increased susceptibility for depression (Lewis, X.  Molecular Psychiatry. 2006;11, 352–360).

http://holisticprimarycare.net/topics/topics-a-g/functional-medicine/1353-mthfr-mutation-a-missing-piece-in-the-chronic-disease-puzzle

My vitamin B6 level is 250. I am taking no supplements that contain B vitamins. However I DO have hashimotos hypothyroidism. I also have a gene mutation (MTHFR) which affects the methylation of B6 B12 and folate in my system. I have been suffering with neuropathy in my feet, tired and tight leg muscles. There are days I can barely walk. I also need to use a cane for out-of-house mobility. Whereas once I went to the gym and participated in Zumba and pilates, I can no longer do anything. Even walking is exhausting. I believe there is a correlation between the hashimotos, MTHFR gene mutation and the problems outlined above. Anyone else with this mutation? Hashis?

I am new to this site and feeling like I have friends that understand.  I have had that spot of skin burning on and off for years.  Some years more often than others. (Haven't had it since I can remember now...)  I have also had just about every other symptom listed so far, at some time or another (this is as far as I've read yet).  The beginning of my hunt for an answer started last Oct when I was suddenly so fatigued I went home and slept for 24 hours.  I assumed I had a virus.  After a couple weeks I saw my primary and fortunately she ran a stool which found dientamoeba fragilis.  A rare 3rd world parasite.  My GI and Infectious Dr.s said "Hmm,  have you been out of the country?  I've seen this once before about 20 years ago..."  (I did not travel.)  SO for a couple months all my NEW symptoms of muscle twitching, skin crawling on my face & in my nose, electric jolt feelings, extreme fatigue, sensitivity to sun, feeling of adrenal rush in my chest and neck, rash on my belly & insomnia...were attributed to either the bug or the antibiotic I had to take.  Fortunately my neuro tested B6 which is elevated to only 33.1 and found my ds-DNA positive.  So, I see a rheumatologist next week and hope for an answer (sounds like Lupus is a possibility).  This site has been a real lift even though no one else so far has mentioned autoimmune disorder.  I will be back for any and all info people post!
Thank you all!!!

I am not a regular on this forum either but do so agree with you.  All the symptoms mentioned are due to gut dysbiosis.  IBS, hypothyroid, skin conditions, malabsorption, diarrhea, constipation, tingling, numbness, etc are all symptoms of celiac, which in turn is a gut condition. 70% of your immune system is in your gut, so start here for autoimmune conditions eg. diabetes, rheumatoid arthritis, allergies, etc.
Check for the following 2 signs:
1.  Braly's Sign - short little finger (top of little finger falls below distal joint of ring finger).  Indicates gluten and lactose intolerance and perhaps Celiac Disease.
2.  Morton's Toe - 2nd toe longer than the big toe.  Indicates the liver has an inability to convert B6 to P5P.  That means you need to supplement with P5P.  B6 can also build up in your body, as it is not getting converted to a usable form.  Many people with this problem can't recall dreams. Other symptoms are depression, skin eruptions, tingling, short term memory loss, irritability and PMS.

My son has both a short little finger and longer second toe.  He also had low thyroid, and impaired function of kidney and liver.  He is making good progress on the GAPS Protocol and expects to follow it for another year. I would recommend this gut healing protocol to everyone.
Hope this helps.
Mary-Pat

Hi, having similar symptoms for years, diagnosed w fibromyalgia and have had horrible gi symptoms for years too. My level was 219, 146 max. I,m on the scdiet, so eat lots of meat. My multi contains abt. 2.8 mg. What i found out is that wit a zinc deficiency, the conversion of b6 info the usable form p5p can be hindered. Zinc is also needed to make gastric acid, tot digest our food. So low zinc will lead to gi trouble fast and enables sibo. Also, b6 goes hand in hand with magnesium. I,m also looking into the MTHFR gene mutation, which involves folate and b6. See article b6 is the queen B on MTHFRalliance.com

Hi Tingle_toes,

How are you doing? I just discovered that, I am low in vit D(14) and very high on Vit B6(104) . Were you able to find the root cause? I am not taking any supplements just wondering where this B6 is coming from? Any help is much appreciated.

Thanks
Sri

hey, anyone have areas of their skin, where the skin seems tender or sore (not the muscles under it, just the skin)? or like a mild.....kind of burning kind of sensation?

Freaks! All of you! :) j/k, I'd been having these neuropathy, not tingling, but electric current type feelings for about 2 weeks now, seemed to be out of nowhere, I had started gabapentin 2 weeks before that (never changed the dose, and can't find info saying it can cause this), they tested by B vit levels, thinking a LOW level could cause this, and they told me the results were all normal...I like to know the numbers so I logged on, the B6 is high, huh, ok, so I look that up.......and google says....."B6 toxicity" causes all this weirdness. I'm not taking B6, or any other B (well B9, but everything says that can't get high, could cause b12 level probs, but nothing about b6 or the b9 having any side effects whatsoever), I haven't taken even my multi vit in...months, and I looked up the food lists, I haven't eaten hardly any of the top, 15 or 20 foods that contain B6........ I've never had these electric current symptoms, it's so weird....and distressing..... (i've had weird neuro things, but not this one, and not one that had a corresponding lab abnormality.....)

I've done some journal searching, and I can't find anything. if my dr's give me one more "lets wait and see" I may just scream.......or throw that box of itchy scratchy hospital kleenex at them.....

Thanks for all the good suggestions about taking care of the gut!!!  I'm a believer!!!!  I wish you well, and I pray that you find no serious condition as a result of all of this, but hopefully a treatable one.  Gut problems are so new to the Western Medicine world, so we are walking experiments for many treatments to come......

I stopped my B complex vitamin upon finding out about the elevated B6 levels, and little by little my hands seem to be responding.  I still have many symptoms, but am chugging along like all the rest!  

Take care!  

Annette