I have experienced similar symptoms over the last 2.5 months. My tongue has felt tired (or almost swollen at times?). I have other issues as well though. I have had full body fasciculations (twitching) for about 10 months now. The twitching started in my right elbow and forearm, and my left tricep, along with my fingers at times. Within a month, I had twitches pretty much everywhere. About 2.5 months ago, my tongue started feeling tired and my jaw would get tired too. My tongue feels weird all the time now, like I can feel it when normally I wouldn't be aware of my tongue being in my mouth. My abdominal muscles feel tired all the time now. I can still stand, jog, lift weights, etc. I have an appointment with a neurologist next thursday. I am not sure what is going on with me. I think the initial twitching started late this past February, with by mid-late March I had twitching pretty much everywhere. I can trigger my own twitching in certain areas as well.

Does anybody have issues with involuntary twitching with no movement, and with flexing of a muscle, you can cause twitches to occur right after you stop contracting the muscle. With my right elbow, if I flex my arm, it will twitch about 5-10 times after I let off of the contraction. I can do the same thing with my abdominal muscles if I contract them. Any thoughts? Is this a typcial ALS sign?

I'm not an ALS expert, but I think the tongue tiredness is symptomatic of bulbar ALS, different from full-body ALS. I don't any fasciculations in the rest of my body. I can't tell if I have fasciculations in my tongue. I heard that you can't feel fasciculations in the tongue, only in the body. However, I can't tell whether or not I have fasciculations in my tongue. If I stick my tongue out, my tongue would move, but it seems more analogous to the slight trembling of the hand than fasciculations.