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Ovarian Cancer (Expert Forum)
Has taxol resistance occurred ?
Answered by
Annekathryn Goodman, M.D. - Gynecologic Cancers, Complex Gynecologic, Surgeries, Palliative Care, Acupuncture
Massachusetts General Hospital Cancer Center
Boston - MA
This forum is for questions and support regarding ovarian cancer issues, such as: Biopsy, Chemotherapy, Clinical Trials, Genetics, Hysterectomy,Immunotherapy, Ovarian Cancer Types, Radiation Therapy, Risk Factors, Screening, Staging, Surgery.
Has taxol resistance occurred ?
by nkhairy, Feb 07, 2007 12:00AM
Dear Dr. Goodman.
My mum, 48 year old, was diagnosed to have ca ovary stage 3 c in 2004. She underwent total abdominal hysterectomy and bilateral salpingo ophrectomy followed by 6 cycles taxol and carboplatin. Her CA 125 dropped dramatically to about <10. She then was started on taxol as maintenance every month for one year. 8 months later, her CA125 rose to 28 and she was restarted again on taxol. Her CA125 stared to decrease while on treatment. In the last 2 months, her CA125 rose again from 14 to 21 and now it is 28. Do you advise to continue on taxol, or taxol resistance has occurred and we need to start her on other chemotherapeutic agent? Thank you.
Nkhairy
My mum, 48 year old, was diagnosed to have ca ovary stage 3 c in 2004. She underwent total abdominal hysterectomy and bilateral salpingo ophrectomy followed by 6 cycles taxol and carboplatin. Her CA 125 dropped dramatically to about <10. She then was started on taxol as maintenance every month for one year. 8 months later, her CA125 rose to 28 and she was restarted again on taxol. Her CA125 stared to decrease while on treatment. In the last 2 months, her CA125 rose again from 14 to 21 and now it is 28. Do you advise to continue on taxol, or taxol resistance has occurred and we need to start her on other chemotherapeutic agent? Thank you.
Nkhairy
Doctor's Answer
by Annekathryn Goodman, M.D., Feb 14, 2007 12:00AM
, Feb 14, 2007 12:00AM
Has your mother had any other studies such as a CT scan? Are we absolutely certain that the Ca 125 reflects cancer and not something else?
best wishes