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Ovarian Cancer (Expert Forum)
CA-125 rise
Answered by
Annekathryn Goodman, M.D. - Gynecologic Cancers, Complex Gynecologic, Surgeries, Palliative Care, Acupuncture
Massachusetts General Hospital Cancer Center
Boston - MA
This forum is for questions and support regarding ovarian cancer issues, such as: Biopsy, Chemotherapy, Clinical Trials, Genetics, Hysterectomy,Immunotherapy, Ovarian Cancer Types, Radiation Therapy, Risk Factors, Screening, Staging, Surgery.
CA-125 rise
by Hazel30, Mar 08, 2007 12:00AM
Hi my Mom is currently under going a clinical trial for MORAB 003 (antibodies) for her slow rising ca-125. She has a clear CT scan of pelvis/abdomen/chest. Her pattern of rise is 5-7 points every 2-4 weeks. So its not too high and obviously slow growing cancer cells. Now, 3 days ago when she began her clinical trial they drew her blood for ca-125 (47) and its up from last weeks ca-125 (34) by 13 points. So in a week it jumped up the highest in such a short time period. BUT 2 days ago she came down with a cold, backache, chest congestion, headache.
So my question is could this high jump be due to the cold. I know its not that much but looking at the patter of her ca-125 rise, the past few months it only been at the highest 7 point jump and in 2-4 week spam. Actualy her second to last ca-125 which was drawn previously in a two week period went up only by 2 points (32 up to 34 in a 2 week period) Now this 13 points in a one week period. We have our hopes that this small recurrence is not aggresive and could be delayed by this trial. I know you can realy see the results only in one treatment but Im more concerned as to why the rise of 13 points in a week.
THANK YOU SO MUCH
-FIANA
So my question is could this high jump be due to the cold. I know its not that much but looking at the patter of her ca-125 rise, the past few months it only been at the highest 7 point jump and in 2-4 week spam. Actualy her second to last ca-125 which was drawn previously in a two week period went up only by 2 points (32 up to 34 in a 2 week period) Now this 13 points in a one week period. We have our hopes that this small recurrence is not aggresive and could be delayed by this trial. I know you can realy see the results only in one treatment but Im more concerned as to why the rise of 13 points in a week.
THANK YOU SO MUCH
-FIANA
Doctor's Answer
by Annekathryn Goodman, M.D., Mar 12, 2007 12:00AM
, Mar 12, 2007 12:00AM
Dear Fiana,
I wonder whether the CA 125 rise is related to the clinical trial. I do not know the details of this particular drug but many biologic therapies can cause inflammatory changes. While someone is on he trial, it is hard to interpret the results of CA 125. Inflammation can also cause back ache. I know that you are worrying about whether the cancer is progressing. You wont have a better sense of that until your mother has another scan.
I know it must be really hard to wait.
take care
I wonder whether the CA 125 rise is related to the clinical trial. I do not know the details of this particular drug but many biologic therapies can cause inflammatory changes. While someone is on he trial, it is hard to interpret the results of CA 125. Inflammation can also cause back ache. I know that you are worrying about whether the cancer is progressing. You wont have a better sense of that until your mother has another scan.
I know it must be really hard to wait.
take care
thank you