Questions posted in the Heart Forum have been answered by doctors from The Cleveland Clinic Foundation.

Question Title: Amiodarone interaction with Mefloquine or Larium

Forum: The Heart Forum
Topic: Tachycardia


I take amiodarone 300mg daily to control atrial fibrillation. We're going to Africa and I will have to take a malaria prophylaxis. As it is a chloroquine resistant area I will have to take Mefloquine or Lariam. Are they compatible with amiodarone? If not any suggestions for prophylaxis for malaria that don't contraindicate with cordarone?
Thanks, Walter



Dear Walter

I am not personally aware of any reported interaction with amiodarone and mefloquine. However, I have not prescribed that combination myself. Check with the doctor that prescribed the mefloquine.

I hope this has been useful. I wish you the best of luck. Feel free to write back.

If you would like to make an appointment at the Cleveland Clinic Heart Center, please call 1-800-CCF-CARE or inquire online by using the Heart Center website at www.ccf.org/heartcenter. The Heart Center website contains a directory of the cardiology staff that can be used to select the physician best suited to address your cardiac problem.



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