Questions in the Gastroenterology and Liver Diseases Forum have been answered by Dr. Kevin Pho who is board certified in Internal Medicine and by doctors from Henry Ford Health System.

Question Title: Familial hyperalphalipoproteinemia

Forum: The Gastroenterology and Liver Diseases Forum
Topic: Cirrhosis


I am trying to find out info on
familial hyperalphalipoproteinemia & am not having any luck.
This seems to be a very rare genetic condition that no one
seems to know much about.
My Lipid panel: total cholesterol: 176 (128-200); triglycerides:
99 (<200); HDL: 106 H (35-86); LDL: 50 (0-130); VLDL: 19
(no ref); LDL/HDL ratio: 0.5 (0.0-3.0); CHOL/HDL ratio: 1.7
Increased apo A-I only leads to Familial hyperalphalipoproteinemia,
pregnancy, or weight reduction. I am 42, had a hysterectomy 14
yrs ago, & have been on estrogen since that time. I am 120 lbs
& have been all of my adult life. My mother died 5 yrs ago
with cirrhosis of the liver, unknown cause. She did not drink
or have hepatitis. An autopsy was done but gave no answers.
Increased HDL levels lead to liver disease according to what I
have found so far which is one sentence in a lab book. I am
hoping that you can shed some light on this rare condition or
direct me to where I can find some more info. I am
trying to obtain my mother's lab work but don't think she ever
had a lipid panel done so probably won't do me any good. In 2 mos
I am having another panel done to make sure the first one wasn't
a fluke. However, it is awfully coincidental that my mom died of
liver disease. There don't seem to be any symptoms until your
liver starts to wear out & you actually develop liver disease.
Is there any treatment to lower the HDL? Is steroids or liver
transplant the only answer?

____
Dear Vicki,
A Medline literature earch did not identify articles that would allow me to answer your questions. I suggest that you find an endocrinologist to help you with your questions.

HFHSM.D.-rf


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Kevin Pho, MD
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