Questions in the Gastroenterology and Liver Diseases Forum have been answered by Dr. Kevin Pho who is board certified in Internal Medicine and by doctors from Henry Ford Health System.

Question Title: Barretts: stomach or intestinal metaplasia

Forum: The Gastroenterology and Liver Diseases Forum
Topic: Barrett's Esophagus


When a biopsy is taken for Barretts, what are the odds that it will reveal stomach vs intestinal metaplasia ? Also, if it is stomach metaplasia rather than intestinal does this mean that it is not Barretts and that one does not have to have regular followups ?

Dear Richard,

Over the years there has been much controversy over the term Barrett's esophagus. The term refers to a change in the lining of the lower esophagus.More recently the term columnar lined mucosa has been introduced.This change in the lining can have three types of columnar epithelia: gastric fundic type(stomach), junctional (cardia-the type lining the area between the esophagus and stomach) and specialized intestinal type (lining looks more like intestinal cells-goblet cells, mucus secreting cells and villiform surface. The specialized intestinal metaplasia (change in the lining) is the most common, and appears to be the most important of the three epithelial types. Dysplasia (glandular distortion) and cancer in Barrett's esophagus almost invariably are associated with specialized intestinal metaplasia. Surveillance endoscopies are currently recommended only for patients who have specialized intestinal metaplasia. I hope you find this information helpful.


This response is being provided for general informational purposes only and should not be considered medical advice or consultation. Always check with your personal physician when you have a question pertaining to your health.

If you would like to be seen at our institution please call 1-800-653-6568, our Referring Physicians’ Office and make an appointment to see Dr. Muszkat, one of our experts in Gastroenterology.

HFHSM.D.-ym
*Keywords: Barrett's esophagus, intestinal metaplasia





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